In:
ACTA Pharmaceutica Sciencia, Acta Pharmaceutica Sciencia, Vol. 60, No. 3 ( 2022), p. 235-
Abstract:
Malaria was successfully treated with both natural and synthetic products. However,
recent progress in battling malaria has stalled due to drug resistance. Therefore, the search of novel antimalarials capable of reversing or evading resistance is
much needed and this could be achieved through ethnomedicinal approaches. Six medicinal plants were screened for their antimalarial activity using the ?-hematin
inhibition (BHI) assay and their effect on the proliferation of three cancer cell lines (A549, MCF7 and PC3) was assessed by the MTT assay. Amongst the twenty-seven
extracts screened, Pseudospondias microcarpa bark showed significant BHI activities with IC50 values of 2.5 ± 0.1 and 4.0 ± 0.2 µg/mL for DCM and MeOH extracts,
respectively, while having no cytotoxic effect on A549, MCF7 and PC3. The current results support the ethnopharmacological use of P. microcarpa in the treatment of
malaria, and it could constitute a useful source of potent antimalarial compounds.
Type of Medium:
Online Resource
ISSN:
2636-8552
DOI:
10.23893/1307-2080.APS.6016
Language:
Unknown
Publisher:
Acta Pharmaceutica Sciencia
Publication Date:
2022
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