In:
BMC Ophthalmology, Springer Science and Business Media LLC, Vol. 21, No. 1 ( 2021-12)
Abstract:
To evaluate the effects of lid debris debridement and meibomian gland expression (MGX) on extracellular matrix metalloproteinase-9 (MMP-9) levels and clinical outcomes of moderate and severe MGD. Methods In this retrospective case series study, a total 48 eyes of 24 patients with moderate and severe MGD underwent one session of lid debris debridement using the BlephEx combined with MGX. We evaluated the tear film break-up time (TBUT), corneal and conjunctival fluorescein staining scores, Schirmer 1 test, biomicroscopic examination of lid margins and meibomian gland (MG), ocular surface disease index (OSDI) questionnaire score, and extracellular MMP-9 levels using a point-of-care MMP-9 immunoassay device before and 4 weeks after lid debris debridement and MGX. Linear mixed model and generalized estimating equations model were used to evaluate possible differences. Results There were significant improvements in the TBUT ( P = 0.002), SICCA and Oxford staining scores (all P 〈 0.001), lid margin telangiectasia ( P 〈 0.001 for upper and lower eyelids), lid thickness ( P 〈 0.001 for upper and lower eyelids), MG orifice plugging ( P 〈 0.001 for upper and lower eyelids), meibum color ( P = 0.026 for upper eyelid, P 〈 0.001 for lower eyelid), meibum consistency ( P 〈 0.001 for upper and lower eyelids), meibum grade ( P 〈 0.001), MGD stage ( P 〈 0.001), and OSDI score ( P = 0.002). MMP-9 immunoassay positivity rate significantly decreased from 83.3 to 50.0% 4 weeks after treatment ( P = 0.014). Conclusions In patients with moderate to severe MGD, lid debris debridement using the BlephEx combined with MGX improved clinical findings, subjective symptoms, meibomian gland function, along with ocular surface MMP-9 level. We hereby suggest lid debris debridement using BlephEx combined with MGX as an effective clinical strategy for treatment of moderate to severe MGD.
Type of Medium:
Online Resource
ISSN:
1471-2415
DOI:
10.1186/s12886-021-01926-2
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2021
detail.hit.zdb_id:
2050436-6
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