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  • 1
    Online Resource
    Online Resource
    COVID-19 infection: an overview on cytokine storm and related interventions
    Springer Science and Business Media LLC ; 2022
    In:  Virology Journal Vol. 19, No. 1 ( 2022-05-26)
    Details
    In: Virology Journal, Springer Science and Business Media LLC, Vol. 19, No. 1 ( 2022-05-26)
    Abstract: Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has posed a significant threat to global health. This virus affects the respiratory tract and usually leads to pneumonia in most patients and acute respiratory distress syndrome (ARDS) in 15% of cases. ARDS is one of the leading causes of death in patients with COVID-19 and is mainly triggered by elevated levels of pro-inflammatory cytokines, referred to as cytokine storm. Interleukins, such as interleukin-6 (1L-6), interleukin-1 (IL-1), interleukin-17 (IL-17), and tumor necrosis factor-alpha (TNF-α) play a very significant role in lung damage in ARDS patients through the impairments of the respiratory epithelium. Cytokine storm is defined as acute overproduction and uncontrolled release of pro-inflammatory markers, both locally and systemically. The eradication of COVID-19 is currently practically impossible, and there is no specific treatment for critically ill patients with COVID-19; however, suppressing the inflammatory response may be a possible strategy. In light of this, we review the efficacy of specific inhibitors of IL6, IL1, IL-17, and TNF-α for treating COVID-19-related infections to manage COVID-19 and improve the survival rate for patients suffering from severe conditions. Graphical Abstract
    Type of Medium: Online Resource
    ISSN: 1743-422X
    URL: Article
    DOI: 10.1186/s12985-022-01814-1
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2160640-7
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  • 2
    Online Resource
    Online Resource
    An overview on the treatments and prevention against COVID-19
    Springer Science and Business Media LLC ; 2023
    In:  Virology Journal Vol. 20, No. 1 ( 2023-02-08)
    Details
    In: Virology Journal, Springer Science and Business Media LLC, Vol. 20, No. 1 ( 2023-02-08)
    Abstract: The coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to plague the world. While COVID-19 is asymptomatic in most individuals, it can cause symptoms like pneumonia, ARDS (acute respiratory distress syndrome), and death in others. Although humans are currently being vaccinated with several COVID-19 candidate vaccines in many countries, however, the world still is relying on hygiene measures, social distancing, and approved drugs. Result There are many potential therapeutic agents to pharmacologically fight COVID-19: antiviral molecules, recombinant soluble angiotensin-converting enzyme 2 (ACE2), monoclonal antibodies, vaccines, corticosteroids, interferon therapies, and herbal agents. By an understanding of the SARS-CoV-2 structure and its infection mechanisms, several vaccine candidates are under development and some are currently in various phases of clinical trials. Conclusion This review describes potential therapeutic agents, including antiviral agents, biologic agents, anti-inflammatory agents, and herbal agents in the treatment of COVID-19 patients. In addition to reviewing the vaccine candidates that entered phases 4, 3, and 2/3 clinical trials, this review also discusses the various platforms that are used to develop the vaccine COVID-19.
    Type of Medium: Online Resource
    ISSN: 1743-422X
    URL: Article
    DOI: 10.1186/s12985-023-01973-9
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2160640-7
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  • 3
    Online Resource
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    Halomonas azerbaijanica sp. nov., a halophilic bacterium isolated from Urmia Lake after the 2015 drought
    Microbiology Society ; 2021
    In:  International Journal of Systematic and Evolutionary Microbiology Vol. 71, No. 1 ( 2021-01-01)
    Details
    In: International Journal of Systematic and Evolutionary Microbiology, Microbiology Society, Vol. 71, No. 1 ( 2021-01-01)
    Abstract: A novel, slightly halophilic bacterium, designated TBZ202 T , was isolated from water of Urmia Lake, in the Azerbaijan region of north-west Iran. The strain was facultatively anaerobic, Gram-stain-negative, rod-shaped and motile. Colonies were creamy, circular, convex and shiny. It grew at NaCl concentrations of 0–12 % (w/v) (optimum 3–5 % w/v), at temperatures of 20–45 °C (optimum 30 °C) and at pH 5.0–10.0 (optimum pH 7.0). Based on the 16S rRNA gene sequence, strain TBZ202 T belongs to the genus Halomonas in the Halomonadaceae and the most closely related species are Halomonas gudaonensis CGMCC 1.6133 T (98.6 % similarity), Halomonas ventosae Al12 T (96.8 %) and Halomonas rambilicola RS-16 T (96.6%). The G+C content was 67.9 % and the digital DNA–DNA hybridization and average nucleotide identity values with H. gudaonensis were 35.8 and 83.8 %, respectively, indicating that the isolate differs from all species described. The major fatty acids were C 18 : 1 ω 7 c , C 16 : 0 and C 16 : 1 ω 7 c . The only respiratory quinone detected was Q-9 and polar lipids consisted of diphosphatidylglycerol, phosphatidylethanolamine, phosphatidylglycerol, aminophospholipid and three unknown phospholipids. On the basis of a polyphasic taxonomic analysis, the isolate is considered to represent a novel species of the genus Halomonas , for which the name Halomonas azerbaijanica sp. nov. is proposed. The type strain is TBZ202 T (=KCTC 62817 T =CECT 9693 T ).
    Type of Medium: Online Resource
    ISSN: 1466-5026 , 1466-5034
    URL: Article
    DOI: 10.1099/ijsem.0.004578
    Language: English
    Publisher: Microbiology Society
    Publication Date: 2021
    detail.hit.zdb_id: 215062-1
    detail.hit.zdb_id: 2056611-6
    SSG: 12
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  • 4
    Online Resource
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    Molecular mechanisms associated with quinolone resistance in Enterobacteriaceae: review and update
    Oxford University Press (OUP) ; 2020
    In:  Transactions of The Royal Society of Tropical Medicine and Hygiene Vol. 114, No. 10 ( 2020-10-05), p. 770-781
    Details
    In: Transactions of The Royal Society of Tropical Medicine and Hygiene, Oxford University Press (OUP), Vol. 114, No. 10 ( 2020-10-05), p. 770-781
    Abstract: Quinolones are broad-spectrum antibiotics, which are used for the treatment of different infectious diseases associated with Enterobacteriaceae. During recent decades, the wide use as well as overuse of quinolones against diverse infections has led to the emergence of quinolone-resistant bacterial strains. Herein, we present the development of quinolone antibiotics, their function and also the different quinolone resistance mechanisms in Enterobacteriaceae by reviewing recent literature. Methods All data were extracted from Google Scholar search engine and PubMed site, using keywords; quinolone resistance, Enterobacteriaceae, plasmid-mediated quinolone resistance, etc. Results and conclusion The acquisition of resistance to quinolones is a complex and multifactorial process. The main resistance mechanisms consist of one or a combination of target-site gene mutations altering the drug-binding affinity of target enzymes. Other mechanisms of quinolone resistance are overexpression of AcrAB-tolC multidrug-resistant efflux pumps and downexpression of porins as well as plasmid-encoded resistance proteins including Qnr protection proteins, aminoglycoside acetyltransferase (AAC(6′)-Ib-cr) and plasmid-encoded active efflux pumps such as OqxAB and QepA. The elucidation of resistance mechanisms will help researchers to explore new drugs against the resistant strains.
    Type of Medium: Online Resource
    ISSN: 0035-9203 , 1878-3503
    URL: Article
    DOI: 10.1093/trstmh/traa041
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2020
    detail.hit.zdb_id: 2135136-3
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  • 5
    Online Resource
    Online Resource
    Removal of U(VI) from aqueous solutions using Shewanella sp. RCRI7, isolated from Qurugöl Lake in Iran
    Walter de Gruyter GmbH ; 2017
    In:  Radiochimica Acta Vol. 105, No. 2 ( 2017-2-1), p. 109-120
    Details
    In: Radiochimica Acta, Walter de Gruyter GmbH, Vol. 105, No. 2 ( 2017-2-1), p. 109-120
    Abstract: Isolation, genotypic and phenotypic characterization of an aqueous bacterium, Shewanella sp RCRI7, from Qurugöl Lake in Iran and uranium removal from aqueous solutions using the isolate is described. Based on 16S rRNA gene sequence analysis and phylogenetic tree, strain RCRI7 T falls into genus Shewanella . Closely related type strains include Shewanella xiamenensis S4 T KJ542801, Shewanella profunda DSM15900 T FR733713, Shewanella putrefaciens LMG 26268 T X81623 and Shewanella oneidensis MR-1 T AE014299. Anaerobic incubation of the bacteria in the presence of U(VI) led to uranium removal from the solution and formation of a black precipitate. Analysis of the precipitate using UV-vis confirmed the reduction of U(VI) to U(IV). The effects of pH, temperature, U(VI) concentration and cell density on uranium removal were elucidated. The maximum uranium removal was 97%. As a conclusion, the findings revealed the ability of the local strain RCRI7 for U(VI) bioreduction as an effective bacterium for uranium immobilization.
    Type of Medium: Online Resource
    ISSN: 2193-3405 , 0033-8230
    URL: Article
    DOI: 10.1515/ract-2016-2628
    Language: English
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2017
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  • 6
    Online Resource
    Online Resource
    Targeting TdT gene expression in Molt-4 cells by PNA-octaarginine conjugates
    Elsevier BV ; 2020
    In:  International Journal of Biological Macromolecules Vol. 164 ( 2020-12), p. 4583-4590
    Details
    In: International Journal of Biological Macromolecules, Elsevier BV, Vol. 164 ( 2020-12), p. 4583-4590
    Type of Medium: Online Resource
    ISSN: 0141-8130
    URL: Article
    DOI: 10.1016/j.ijbiomac.2020.09.081
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2020
    detail.hit.zdb_id: 1483284-7
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  • 7
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    Polycyclic Aromatic Hydrocarbons Degradation by Aquatic Bacteria Isolated from Khazar Sea, the World’s Largest Lake
    Maad Rayan Publishing Company ; 2020
    In:  Pharmaceutical Sciences Vol. 27, No. 1 ( 2020-04-02), p. 121-130
    Details
    In: Pharmaceutical Sciences, Maad Rayan Publishing Company, Vol. 27, No. 1 ( 2020-04-02), p. 121-130
    Abstract: Background: Aquatic microorganisms have an important role in the bioremediation of environmental pollutants. Polycyclic Aromatic Hydrocarbons (PAHs) are described as dangerous pollutants that can bind covalently to the nucleic acids, causing mutations. Therefore, they have carcinogenic and toxic properties. Also, are involved in diseases such as asthma, lung dysfunction, and chronic bronchitis. This study aimed to isolate and characterize aquatic bio-degrading bacteria from the world’s largest lake, Khazar, with the ability to use PAHs as only carbon source. Methods: Samples were taken from the estuary of Siah Rud River (Mazandaran province, Iran) and Fereydunkenar beach leading to isolation of twenty-three bacteria on marine agar and sea water media. The isolates were cultured on separate ONR7a medium, each supplemented with only one PAH; as the sole carbon source; including naphthalene, phenanthrene, and anthracene. Results: Eleven bacterial isolates were able to grow on supplemented media: TBZ-E1, TBZ-E2, TBZ-E3, TBZ-S12, TBZ-S16, TBZ-E20, TBZ-SF2, TBZ-F1, TBZ-F2, TBZ-F3 and TBZ2. These isolates belong to Alteromonas, Marivivens, Pseudoalteromonas, Vibrio, Shewanella, Photobacterium, Mycobacterium and Pseudomonas genera. The qualitative analysis showed that the consortium of isolates TBZ-F1, TBZ-F2, TBZ-F3, TBZ-SF2, and TBZ2 displayed the highest degradation rate for phenanthrene and naphthalene. Naphthalene, phenanthrene, and anthracene were potently degraded by TBZ2 and TBZ-SF2 and accordingly were subjected to measure degradation potential of mentioned PAHs. Conclusion: The bacterial isolates of Caspian lake have a critical duty in biodegradation of PAHs. These isolates are representative samples of the bacterial population of this lake, participating in the purification process of this habitat.
    Type of Medium: Online Resource
    ISSN: 1735-403X , 2383-2886
    URL: Article
    DOI: 10.34172/PS.2020.28
    Language: English
    Publisher: Maad Rayan Publishing Company
    Publication Date: 2020
    detail.hit.zdb_id: 2818425-7
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  • 8
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    Online Resource
    Antimicrobial Peptides (AMPs): Roles, Functions and Mechanism of Action
    Springer Science and Business Media LLC ; 2020
    In:  International Journal of Peptide Research and Therapeutics Vol. 26, No. 3 ( 2020-09), p. 1451-1463
    Details
    In: International Journal of Peptide Research and Therapeutics, Springer Science and Business Media LLC, Vol. 26, No. 3 ( 2020-09), p. 1451-1463
    Type of Medium: Online Resource
    ISSN: 1573-3149 , 1573-3904
    URL: Article
    DOI: 10.1007/s10989-019-09946-9
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 2192632-3
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  • 9
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    Online Resource
    Recent Advances in Therapeutic Peptides for Breast Cancer Treatment
    Bentham Science Publishers Ltd. ; 2021
    In:  Current Protein & Peptide Science Vol. 22, No. 1 ( 2021-01), p. 74-88
    Details
    In: Current Protein & Peptide Science, Bentham Science Publishers Ltd., Vol. 22, No. 1 ( 2021-01), p. 74-88
    Abstract: Breast cancer is a heterogeneous malignancy and is the second leading cause of mortality among women around the world. Increasing the resistance to anti-cancer drugs in breast cancer cells persuades researchers to search the novel therapeutic approaches for the treatment of this malignancy. Among the novel methods, therapeutic peptides that target and disrupt tumor cells have been of great interest. Therapeutic peptides are short amino acid monomer chains with high specificity to bind and modulate a protein interaction of interest. Several advantages of peptides, such as specific binding on tumor cells surface, low molecular weight, and low toxicity on normal cells, make the peptides appealing therapeutic agents against solid tumors, particularly breast cancer. Also, the National Institutes of Health (NIH) describes therapeutic peptides as a suitable candidate for the treatment of drug-resistant breast cancer. In this review, we attempt to review the different therapeutic peptides against breast cancer cells that can be used in the treatment and diagnosis of the malignancy. Meanwhile, we presented an overview of peptide vaccines that have been developed for the treatment of breast cancer.
    Type of Medium: Online Resource
    ISSN: 1389-2037
    URL: Article
    DOI: 10.2174/1389203721999201117123616
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2021
    SSG: 12
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  • 10
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    CpG Islands Methylation Analysis of CDH11, EphA5, and HS3ST2 Genes in Gastric Adenocarcinoma Patients
    Springer Science and Business Media LLC ; 2020
    In:  Journal of Gastrointestinal Cancer Vol. 51, No. 2 ( 2020-06), p. 579-583
    Details
    In: Journal of Gastrointestinal Cancer, Springer Science and Business Media LLC, Vol. 51, No. 2 ( 2020-06), p. 579-583
    Type of Medium: Online Resource
    ISSN: 1941-6628 , 1941-6636
    URL: Article
    DOI: 10.1007/s12029-019-00290-1
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 2466657-9
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