In:
Clinical Endocrinology, Wiley, Vol. 87, No. 6 ( 2017-12), p. 673-679
Abstract:
Hyperandrogenism, hyperinsulinaemia and obesity, known characteristics of polycystic ovary syndrome ( PCOS ), may influence bone mineral density and biochemical markers of bone turnover ( BTM s) can provide a noninvasive assessment of bone turnover. To this end, the serum concentrations of BTM s and 25‐hydroxyvitamin D (25 OHD ) were analysed in women with PCOS , and their possible associations with metabolic parameters of PCOS were determined. Subjects and methods Bone formation markers procollagen type I amino‐terminal propeptide ( PINP ) and osteocalcin ( OC ), and bone resorption marker carboxy‐terminal cross‐linking telopeptide of type I collagen ( CTX ), along with 25 OHD , were measured in 298 women with PCOS and 194 healthy controls. Results Serum levels of PINP (47.0 ± 20.2 vs 58.1 ± 28.6 μg/L, P 〈 .001) and OC (18.2 ± 7.5 vs 20.6 ± 9.8 μg/L, P 〈 .001) were decreased in women with PCOS compared with controls, whereas no significant differences were found in CTX and 25 OHD levels. Age‐stratified analyses suggested that PINP (50.5 ± 21.7 vs 68.2 ± 26.6 μg/L, P 〈 .001) and OC levels (20.4 ± 7.6 vs 25.5 ± 9.6 μg/L, P 〈 .001) were decreased only in the younger age group (≤30 years) women with PCOS compared with controls. The formation markers and resorption marker decreased with age in both study groups. Conclusions Bone formation markers were decreased in younger women with PCOS when compared with healthy women, which may affect bone mass in these women.
Type of Medium:
Online Resource
ISSN:
0300-0664
,
1365-2265
DOI:
10.1111/cen.2017.87.issue-6
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
2004597-9
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