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  • 1
    Online Resource
    Online Resource
    Star-shaped small molecular donors based on a Zn-Porphyrin core and DPP arms via different linkers for organic solar cells
    Elsevier BV ; 2021
    In:  Dyes and Pigments Vol. 188 ( 2021-04), p. 109216-
    Details
    In: Dyes and Pigments, Elsevier BV, Vol. 188 ( 2021-04), p. 109216-
    Type of Medium: Online Resource
    ISSN: 0143-7208
    URL: Article
    DOI: 10.1016/j.dyepig.2021.109216
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2021
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  • 2
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    Fully-unfused electron acceptors based on a steric boron dipyrromethene (BODIPY) core for organic solar cells
    Royal Society of Chemistry (RSC) ; 2023
    In:  New Journal of Chemistry Vol. 47, No. 25 ( 2023), p. 11792-11799
    Details
    In: New Journal of Chemistry, Royal Society of Chemistry (RSC), Vol. 47, No. 25 ( 2023), p. 11792-11799
    Abstract: In this study, two electron acceptors with fully-unfused conformations, namely MBTIC-4F and MBTIC-4Cl, are facilely developed with a steric boron dipyrromethene (BODIPY) derivative as core, single thiophene as bridges, and fluorinated and chlorinated dicyanoindanone as endcaps. Benefiting from the steric BODIPY core, both the fully-unfused electron acceptors (FUEAs) show twisted geometries to avoid excessive intermolecular stacking and achieve satisfactory sunlight capture contributed by the inherent high extinction coefficient of BODIPY. Blending with the polymer donor PBDB-T, MBTIC-4Cl affords a better power conversion efficiency of 3.47% than MBTIC-4F of 2.03% in the corresponding organic solar cells. The disparities in crystallinity and miscibility are unraveled to be responsible for differential photovoltaic performance. More specifically, chlorinated MBTIC-4Cl demonstrates a stronger crystalline structure, lower miscibility with PBDB-T, and large-scale pure acceptor domains in the relevant blends, resulting in favorable morphology to guarantee sufficient exciton dissociation, high electron mobility, and balanced charge transport. This study reveals great potential for achieving cost-effective FUEAs by employing a BODIPY core via an appropriate molecular design.
    Type of Medium: Online Resource
    ISSN: 1144-0546 , 1369-9261
    URL: Article
    DOI: 10.1039/D3NJ00845B
    Language: English
    Publisher: Royal Society of Chemistry (RSC)
    Publication Date: 2023
    detail.hit.zdb_id: 622959-1
    detail.hit.zdb_id: 1472933-7
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  • 3
    Online Resource
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    Data_Sheet_1.pdf
    Frontiers Media SA ; 2023
    In:  Frontiers in Public Health Vol. 11 ( 2023-4-27)
    Details
    In: Frontiers in Public Health, Frontiers Media SA, Vol. 11 ( 2023-4-27)
    Abstract: To investigate the relationship between antibiotic exposure and asthma in adults in the United States. Methods Data was obtained from the National Health and Nutrition Examination Survey (NHANES) conducted between 1999 and 2018. A total of 51,124 participants were included, excluding those who were aged & lt; 20 years, female participants who were pregnant, and individuals who did not complete the prescription medications questionnaire and the medical conditions questionnaire regarding asthma status. Antibiotic exposure was defined as the utilization of antibiotics within the past 30 days, categorized based on the Multum Lexicon Plus therapeutic classification system. Asthma was defined as having a history of asthma or having an asthma attack or wheezing symptoms in the past year. Results The risk of asthma was found to be 2.557 (95% CI: 1.811, 3.612), 1.547 (95% CI: 1.190, 2.011) and 2.053 (95% CI: 1.344, 3.137) times greater in participants who had used macrolide derivatives, penicillin and quinolones in the past 30 days, respectively, compared with those not using antibiotics. After adjusting for demographic covariates and asthma-related factors, only macrolides derivatives were significantly associated with asthma in the 20–40 and 40–60 age groups. For individuals over 60 years old, quinolones were significantly associated with asthma. The effect of different types of antibiotic with asthma varied in male and female populations. Moreover, higher socioeconomic status, greater BMI, younger age, smoking habits, history of infection, chronic bronchitis, emphysema, and family history of asthma were all identified as risk factors for asthma. Conclusion Our study indicated that three types of antibiotics were significantly associated with asthma in different subgroups of the population. Therefore, the use of antibiotics should be more strictly regulated.
    Type of Medium: Online Resource
    ISSN: 2296-2565
    URL: Article
    URL: Article
    DOI: 10.3389/fpubh.2023.1123555
    DOI: 10.3389/fpubh.2023.1123555.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2711781-9
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  • 4
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    Online Resource
    Higher serum ferritins are associated with higher blood pressure: A cross-sectional study
    Ovid Technologies (Wolters Kluwer Health) ; 2024
    In:  Medicine Vol. 103, No. 12 ( 2024-03-22), p. e37485-
    Details
    In: Medicine, Ovid Technologies (Wolters Kluwer Health), Vol. 103, No. 12 ( 2024-03-22), p. e37485-
    Abstract: The aim of the study was to investigate the association between serum ferritin and hypertension among American adults from National Health and Nutrition Examination Survey (NHANES) 1999 to 2018. A total of 16,125 participants were included. Weighted logistic regression and subgroup analyses were performed to explore the association. We found that serum ferritin was closely correlated to hypertension. Individuals with high serum ferritin were more likely to have higher systolic or diastolic blood pressure (SBP, DBP) than those with lower serum ferritin. Restricted cubic spline showed a significant non-linear association between serum ferritin and SBP/DBP. Higher level of serum ferritin (Q3 74.1–147 μg/L and Q4  〉  147 μg/L) was found to have positive association with high SBP [Q3 (OR: 1.246, 95% CI:1.020–1.523), Q4 (OR: 1.354, 95% CI:1.096–1.674)], and hypertension [Q3 (OR: 1.283, 95% CI:1.099–1.499), Q4 (OR: 1.424, 95% CI:1.197–1.63)] in the whole population. In people aged between 20 and 60, subjects with high serum ferritin were significantly associated with a higher risk of hypertension, but in those over 60, the relationship between serum ferritin level and hypertension is negative. A non-linear association between serum ferritin and SBP, as well as DBP, was discovered. There was age difference in association between serum ferritin and hypertension in American adults, and further researches were needed to understand the mechanisms behind the difference.
    Type of Medium: Online Resource
    ISSN: 0025-7974 , 1536-5964
    URL: Article
    DOI: 10.1097/MD.0000000000037485
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2024
    detail.hit.zdb_id: 2049818-4
    detail.hit.zdb_id: 80184-7
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  • 5
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    Online Resource
    BODIPY Cored A−D−A'−D−A Type Nonfused‐Ring Electron Acceptor for Efficient Polymer Solar Cells
    Wiley ; 2022
    In:  Macromolecular Rapid Communications Vol. 43, No. 22 ( 2022-11)
    Details
    In: Macromolecular Rapid Communications, Wiley, Vol. 43, No. 22 ( 2022-11)
    Abstract: In this work, boron dipyrromethene (BODIPY) is for the first time employed as electron‐deficient core (A’) to construct an A–D–A’–D–A type nonfused‐ring electron acceptor (NFREA) for polymer solar cells (PSCs). Among, cyclopentadithiophene (CPDT) and fluorinated dicyanoindanone (DFIC) are involved as electron‐donating (D) bridges and terminal A groups, respectively. Bearing with the steric BODIPY core, tMBCIC exhibits twisted configuration with dihedral angles 〉 45 °  between BODIPY and CPDT bridges. Thus, compared with the BODIPY‐free planar A–D–D–A structured bCIC, reduced aggregation, weakened intramolecular D–A interactions with up‐shifted lowest unoccupied molecular orbital by 0.4 eV as well as blueshifted absorption by up to 150 nm is observed in tMBCIC. Moreover, owing to the intrinsic large molar extinction coefficient from BODIPY, promoted light‐harvest ability is achieved for tMBCIC, particularly in its blend films. Therefore, PSCs by using PBDB‐T as donor, tMBCIC as NFREA afford superior power conversion efficiency (PCE) of 9.22% and higher open‐circuit voltage ( V oc ) of 0.954 V compared to 4.47% and 0.739 V from bCIC‐devices. Moreover, compared to other BODIPY‐flanked electron acceptors ( 〈 5%) reported so far, BODIPY‐cored tMBCIC realizes a remarkable progress in PCE.
    Type of Medium: Online Resource
    ISSN: 1022-1336 , 1521-3927
    URL: Issue
    URL: Article
    DOI: 10.1002/marc.v43.22
    DOI: 10.1002/marc.202100828
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 1475027-2
    detail.hit.zdb_id: 1176770-4
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  • 6
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    Online Resource
    BODIPY-modified terpolymer donors for efficient fullerene- and nonfullerene-polymer solar cells
    Royal Society of Chemistry (RSC) ; 2021
    In:  Journal of Materials Chemistry C Vol. 9, No. 22 ( 2021), p. 7035-7045
    Details
    In: Journal of Materials Chemistry C, Royal Society of Chemistry (RSC), Vol. 9, No. 22 ( 2021), p. 7035-7045
    Type of Medium: Online Resource
    ISSN: 2050-7526 , 2050-7534
    URL: Article
    DOI: 10.1039/D1TC01290H
    Language: English
    Publisher: Royal Society of Chemistry (RSC)
    Publication Date: 2021
    detail.hit.zdb_id: 2702245-6
    detail.hit.zdb_id: 2705156-0
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  • 7
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    Joint effect of BMI and metabolic status on mortality among adults: a population-based longitudinal study in United States
    Springer Science and Business Media LLC ; 2024
    In:  Scientific Reports Vol. 14, No. 1 ( 2024-02-02)
    Details
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 14, No. 1 ( 2024-02-02)
    Abstract: We explored the joint effects of different metabolic obesity phenotypes on all-cause and disease-specific mortality risk among the American population. Data were obtained from the National Health and Nutrition Examination Survey (NHANES) 1999–2018. Mortality outcome data were from mortality files linked to National Death Index record and follow-up information was up to December 31, 2019. 50,013 participants were finally included. Four metabolic obesity phenotypes were defined based on obesity and metabolic status: metabolically healthy obese (MHO), metabolically unhealthy obese (MUO), metabolically healthy non-obese (MHNO), and metabolically unhealthy non-obese (MUNO). Population-weighted Cox proportional hazards models were used to explore the all-cause and disease-specific mortality risk of metabolic obesity phenotypes. The all-cause mortality risk of MUO and MUNO was significantly higher than MHNO. MUNO was associated with a significantly increased risk of death from heart disease (HR: 1.40, 95% CI 1.16–1.70), hypertension (HR: 1.68, 95% CI 1.34–2.12), diabetes (HR: 2.29, 95% CI 1.67–3.15), and malignant neoplasms (HR:1.29, 95% CI 1.09–1.53). Metabolic unhealth significantly increased the risk of all-cause mortality, regardless of obesity status. Among individuals with metabolic unhealthy status, obesity significantly reduced the risk of all-cause mortality (HR: 0.91, 95% CI 0.85–0.98). Our study highlights the importance of identifying and characterizing metabolic obesity phenotypes in obese and metabolically abnormal patients, as well as healthy adults. Comprehensive evaluation of obesity and metabolic status is necessary to adopt appropriate interventions and treatment measures and maximize patient benefit.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    URL: Article
    DOI: 10.1038/s41598-024-53229-3
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2024
    detail.hit.zdb_id: 2615211-3
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  • 8
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    Online Resource
    “Fatty” or “steatotic”: position statement from a linguistic perspective by the Chinese-speaking community
    Elsevier BV ; 2024
    In:  Journal of Hepatology ( 2024-5)
    Details
    In: Journal of Hepatology, Elsevier BV, ( 2024-5)
    Type of Medium: Online Resource
    ISSN: 0168-8278
    URL: Article
    DOI: 10.1016/j.jhep.2024.05.031
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2024
    detail.hit.zdb_id: 605953-3
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  • 9
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    Online Resource
    C/EBPα/miR‐7 Controls CD4+ T‐Cell Activation and Function and Orchestrates Experimental Autoimmune Hepatitis in Mice
    Ovid Technologies (Wolters Kluwer Health) ; 2021
    In:  Hepatology Vol. 74, No. 1 ( 2021-07), p. 379-396
    Details
    In: Hepatology, Ovid Technologies (Wolters Kluwer Health), Vol. 74, No. 1 ( 2021-07), p. 379-396
    Abstract: Increasing evidence in recent years has suggested that microRNA‐7 (miR‐7) is an important gene implicated in the development of various diseases including HCC. However, the role of miR‐7 in autoimmune hepatitis (AIH) is unknown. Approach and Results Herein, we showed that miR‐7 deficiency led to exacerbated pathology in Concanavalin‐A‐induced murine acute autoimmune liver injury (ALI) model, accompanied by hyperactivation state of CD4 + T cells. Depletion of CD4 + T cells reduced the effect of miR‐7 deficiency on the pathology of ALI. Interestingly, miR‐7 deficiency elevated CD4 + T‐cell activation, proliferation, and cytokine production in vitro . Adoptive cell transfer experiments showed that miR‐7 def CD4 + T cells could exacerbate the pathology of ALI. Further analysis showed that miR‐7 expression was up‐regulated in activated CD4 + T cells. Importantly, the transcription of pre‐miR‐7b, a major resource of mature miR‐7 in CD4 + T cells, was dominantly dependent on transcription factor CCAAT enhancer binding protein alpha (C/EBPα), which binds to the core promoter region of the miR‐7b gene. Global gene analysis showed that mitogen‐activated protein kinase 4 (MAPK4) is a target of miR‐7 in CD4 + T cells. Finally, the loss of MAPK4 could ameliorate the activation state of CD4 + T cells with or without miR‐7 deficiency. Our studies document the important role of miR‐7 in the setting of AIH induced by Concanavalin‐A. Specifically, we provide evidence that the C/EBPα/miR‐7 axis negatively controls CD4 + T‐cell activation and function through MAPK4, thereby orchestrating experimental AIH in mice. Conclusions This study expands on the important role of miR‐7 in liver‐related diseases and reveals the value of the C/EBPα/miR‐7 axis in CD4 + T‐cell biological function for the pathogenesis of immune‐mediated liver diseases.
    Type of Medium: Online Resource
    ISSN: 0270-9139 , 1527-3350
    URL: Article
    DOI: 10.1002/hep.31607
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2021
    detail.hit.zdb_id: 604603-4
    detail.hit.zdb_id: 1472120-X
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  • 10
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    USP10 as a Potential Therapeutic Target in Human Cancers
    MDPI AG ; 2022
    In:  Genes Vol. 13, No. 5 ( 2022-05-06), p. 831-
    Details
    In: Genes, MDPI AG, Vol. 13, No. 5 ( 2022-05-06), p. 831-
    Abstract: Deubiquitination is a major form of post-translational protein modification involved in the regulation of protein homeostasis and various cellular processes. Deubiquitinating enzymes (DUBs), comprising about five subfamily members, are key players in deubiquitination. USP10 is a USP-family DUB featuring the classic USP domain, which performs deubiquitination. Emerging evidence has demonstrated that USP10 is a double-edged sword in human cancers. However, the precise molecular mechanisms underlying its different effects in tumorigenesis remain elusive. A possible reason is dependence on the cell context. In this review, we summarize the downstream substrates and upstream regulators of USP10 as well as its dual role as an oncogene and tumor suppressor in various human cancers. Furthermore, we summarize multiple pharmacological USP10 inhibitors, including small-molecule inhibitors, such as spautin-1, and traditional Chinese medicines. Taken together, the development of specific and efficient USP10 inhibitors based on USP10’s oncogenic role and for different cancer types could be a promising therapeutic strategy.
    Type of Medium: Online Resource
    ISSN: 2073-4425
    URL: Article
    DOI: 10.3390/genes13050831
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2527218-4
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