In:
PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 4 ( 2022-4-18), p. e0266688-
Abstract:
Several studies in the past have reported positive correlations between circulating Serum amyloid A (SAA) levels and obesity. However, based on limited number of studies involving appropriate mouse models, the role of SAA in the development of obesity and obesity-related metabolic consequences has not been established. Accordingly, herein, we have examined the role of SAA in the development of obesity and its associated metabolic complications in vivo using mice deficient for all three inducible forms of SAA: SAA1.1, SAA2.1 and SAA3 (TKO). Male and female mice were rendered obese by feeding a high fat, high sucrose diet with added cholesterol (HFHSC) and control mice were fed rodent chow diet. Here, we show that the deletion of SAA does not affect diet-induced obesity, hepatic lipid metabolism or adipose tissue inflammation. However, there was a modest effect on glucose metabolism. The results of this study confirm previous findings that SAA levels are elevated in adipose tissues as well as in the circulation in diet-induced obese mice. However, the three acute phase SAAs do not play a causative role in the development of obesity or obesity-associated adipose tissue inflammation and dyslipidemia.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0266688
DOI:
10.1371/journal.pone.0266688.g001
DOI:
10.1371/journal.pone.0266688.g002
DOI:
10.1371/journal.pone.0266688.g003
DOI:
10.1371/journal.pone.0266688.g004
DOI:
10.1371/journal.pone.0266688.g005
DOI:
10.1371/journal.pone.0266688.g006
DOI:
10.1371/journal.pone.0266688.g007
DOI:
10.1371/journal.pone.0266688.g008
DOI:
10.1371/journal.pone.0266688.s001
DOI:
10.1371/journal.pone.0266688.s002
DOI:
10.1371/journal.pone.0266688.s003
DOI:
10.1371/journal.pone.0266688.s004
DOI:
10.1371/journal.pone.0266688.s005
DOI:
10.1371/journal.pone.0266688.s006
DOI:
10.1371/journal.pone.0266688.s007
DOI:
10.1371/journal.pone.0266688.s008
DOI:
10.1371/journal.pone.0266688.s009
DOI:
10.1371/journal.pone.0266688.s010
DOI:
10.1371/journal.pone.0266688.s011
DOI:
10.1371/journal.pone.0266688.r001
DOI:
10.1371/journal.pone.0266688.r002
DOI:
10.1371/journal.pone.0266688.r003
DOI:
10.1371/journal.pone.0266688.r004
DOI:
10.1371/journal.pone.0266688.r005
DOI:
10.1371/journal.pone.0266688.r006
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2267670-3
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