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  • 1
    Online Resource
    Online Resource
    Livelihood Capital Effects on Famers’ Strategy Choices in Flood-Prone Areas—A Study in Rural China
    MDPI AG ; 2022
    In:  International Journal of Environmental Research and Public Health Vol. 19, No. 12 ( 2022-06-20), p. 7535-
    Details
    In: International Journal of Environmental Research and Public Health, MDPI AG, Vol. 19, No. 12 ( 2022-06-20), p. 7535-
    Abstract: The global climate change has resulted in huge flood damages, which seriously hinders the sustainable development of rural economy and society and causes famers’ livelihood problems. In flood-prone areas, it is imperative to actively study short and long-term strategies and solve farmers’ livelihood problems accordingly. Following the sustainable development analysis framework proposed by the Department for International Development (DFID), this study collects empirical data of 360 rural households in six sample villages in the Jialing River Basin of Sichuan Province, China through a village-to-household field questionnaire and applies the Multinominal Logit Model (MNL) to explore the influence of farmer households’ capital on livelihood strategy choice. Research results show that: (1) In human capital category, the education level of the household head has a significant positive impact on the livelihood strategies of farmers’ families; (2) In physical capital category, farmer households with larger space have more funds to choose among flood adaptation strategies; (3) In natural capital category, house location and the sale of family property for cash have the greatest negative impact on farmers’ livelihood strategies; (4) Rural households with more credit opportunities in financial capital are more willing to obtain emergency relief funds; (5) Farmers’ families helped by the village for a long time will probably not choose to move to avoid floods, but are more likely to choose buying flood insurance. This study provides an empirical reference for effective short and long term prevention and mitigation strategies design and application in rural in flood-prone areas.
    Type of Medium: Online Resource
    ISSN: 1660-4601
    URL: Article
    DOI: 10.3390/ijerph19127535
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2175195-X
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  • 2
    Online Resource
    Online Resource
    Factors Driving BIM Learning Performance: Research on China’s Sixth National BIM Graduation Design Innovation Competition of Colleges and Universities
    MDPI AG ; 2021
    In:  Buildings Vol. 11, No. 12 ( 2021-12-06), p. 616-
    Details
    In: Buildings, MDPI AG, Vol. 11, No. 12 ( 2021-12-06), p. 616-
    Abstract: With the popularization and rise in BIM technology usage, BIM education for undergraduate students in architecture, engineering, and construction (AEC) related disciplines has emerged as a priority. This study assesses the BIM learning outcomes of students participating in the National BIM Graduation Design Innovation Competition of Colleges and Universities. In total, 2777 valid questionnaire responses were obtained for this study. The Cronbach’s alpha coefficient method and principal component factor analysis method were used to verify the reliability of the data set (Cronbach’s alpha = 0.962, KMO = 0.965). The t-test (ANOVA) was used to verify that gender, school type, major, grade, study duration and use BIM related software, as well as other demographic attributes, displayed significant inter-group differences. Seven common factors affecting BIM learning performance were obtained by exploratory factor analysis: (1) ability of the instructor, (2) school (college) atmosphere, (3) teamwork, (4) individual ability, (5) understanding of BIM industry applications, (6) social environment incentives, and (7) achievement demand. Finally, the results of an ordered logistic regression revealed that the demographic attributes of participants, the comprehensive ability of the instructor, teamwork, individual ability, and achievement demand significantly affects BIM learning performance. Based on these findings, this paper puts forward suggestions for improving BIM learning performance and provides theoretical support for BIM education and learning in AEC related undergraduate majors.
    Type of Medium: Online Resource
    ISSN: 2075-5309
    URL: Article
    DOI: 10.3390/buildings11120616
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2661539-3
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  • 3
    Online Resource
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    DataSheet1.pdf
    Frontiers Media SA ; 2022
    In:  Frontiers in Environmental Science Vol. 10 ( 2022-6-15)
    Details
    In: Frontiers in Environmental Science, Frontiers Media SA, Vol. 10 ( 2022-6-15)
    Abstract: Earthquake is one of the most serious natural disasters. Taking scientific and reasonable earthquake preparedness measures can effectively reduce casualties and economic losses caused by earthquakes. It is important to understand how residents choose such earthquake preparedness measures to guide them accordingly. However, the current research has failed to address rural areas in developing countries and has inconsistency conclusions for two aspects related to stakeholders involved: the assistance the victims can get from stakeholders for applying earthquake preparedness measures and the trust in stakeholders’ disaster relief abilities. In this study, the rural residents affected by Wenchuan earthquake, Ya’an earthquake and Yibin earthquake were taken as the research objects, and 674 valid questionnaires were obtained through field household surveys. A Multinominal Logit Model (MNL) was constructed to explore the influence of villagers’ trust in the disaster relief ability of stakeholders and the help they can get from stakeholders on their preparedness behavior. The results show that the less trust the villagers have on the government and the community, and the more help they can get from the outside while preparing measures, the more inclined they are to take the disaster preparedness measures. Furthermore, the education level of villagers in earthquake-stricken areas has significant positive impacts on people’s earthquake preparedness behavior. People who are not born in rural areas are more likely to take earthquake preparedness measures. In addition, male, young and married villagers are more likely to take earthquake preparedness measures in their daily lives. This study enriches the theory of rural disaster prevention and mitigation, and provides reference for the practice of disaster prevention and mitigation in earthquake-stricken rural areas.
    Type of Medium: Online Resource
    ISSN: 2296-665X
    URL: Article
    URL: Article
    DOI: 10.3389/fenvs.2022.926432
    DOI: 10.3389/fenvs.2022.926432.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2741535-1
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  • 4
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    Online Resource
    HSF1 Protects Sepsis-Induced Acute Lung Injury by Inhibiting NLRP3 Inflammasome Activation
    Frontiers Media SA ; 2022
    In:  Frontiers in Immunology Vol. 13 ( 2022-6-1)
    Details
    In: Frontiers in Immunology, Frontiers Media SA, Vol. 13 ( 2022-6-1)
    Abstract: As an important transcription factor, heat shock factor 1 (HSF1) plays an endogenous anti-inflammation role in the body and can alleviate multiple organ dysfunction caused by sepsis, which contributes to an uncontrolled inflammatory response. The NLRP3 inflammasome is a supramolecular complex that plays key roles in immune surveillance. Inflammation is accomplished by NLRP3 inflammasome activation, which leads to the proteolytic maturation of IL-1β and pyroptosis. However, whether HSF1 is involved in the activation of the NLRP3 inflammasome in septic acute lung injury (ALI) has not been reported. Here, we show that HSF1 suppresses NLRP3 inflammasome activation in transcriptional and post-translational modification levels. HSF1 can repress NLRP3 expression via inhibiting NF-κB phosphorylation. HSF1 can inhibit caspase-1 activation and IL-1β maturation via promoting NLRP3 ubiquitination. Our finding not only elucidates a novel mechanism for HSF1-mediated protection of septic ALI but also identifies new therapeutic targets for septic ALI and related diseases.
    Type of Medium: Online Resource
    ISSN: 1664-3224
    URL: Article
    DOI: 10.3389/fimmu.2022.781003
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2606827-8
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  • 5
    Online Resource
    Online Resource
    Application of blended teaching model based on SPOC and TBL in dermatology and venereology
    Springer Science and Business Media LLC ; 2021
    In:  BMC Medical Education Vol. 21, No. 1 ( 2021-12)
    Details
    In: BMC Medical Education, Springer Science and Business Media LLC, Vol. 21, No. 1 ( 2021-12)
    Abstract: In this study, we applied the small private online course (SPOC) and team-based learning (TBL) blended teaching model to dermatology and venereology to ensure a higher quality learning experience for clinical medical students. Methods A total of 52 fifth-grade clinical undergraduates from Xiangya School of Medicine of Central South University were randomly divided into an experimental ( n = 26) and a control group ( n = 26). In March 2018, we used the SPOC and TBL blended teaching model in the experimental group and explored the effects of innovative teaching in the dermatology and venereology course, compared with the control group receiving the conventional teaching method. We analyzed the two groups’ theoretical assessment scores and questionnaire results to evaluate the efficiency of the new pedagogy. Results Students in the experimental group had a better understanding than the control group of the dermatology and venereology content and higher scores on the case analysis questions in the final theoretical examination. The results revealed that the majority of the experimental group students agreed that the novel teaching model blended with SPOC & TBL helped them significantly stimulate motivation and develop their ability in self-directed learning, independent thinking, literature retrieval, presentation board, teamwork, communication, and systematic clinical thinking. The teaching satisfaction survey of the two groups showed that the students’ satisfaction in the experimental group was significantly higher than in the control group ( p 〈 0.05). Conclusions The SPOC & TBL teaching model is better than the traditional one in enriching students’ professional knowledge and cultivating their comprehensive ability. It can effectively promote educational quality, improve students’ learning effects, and enhance their satisfaction. This method has broad application prospects.
    Type of Medium: Online Resource
    ISSN: 1472-6920
    URL: Article
    DOI: 10.1186/s12909-021-03042-7
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2044473-4
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  • 6
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    Online Resource
    Comprehensive analysis of pre-mRNA alternative splicing regulated by m6A methylation in pig oxidative and glycolytic skeletal muscles
    Springer Science and Business Media LLC ; 2022
    In:  BMC Genomics Vol. 23, No. 1 ( 2022-12-06)
    Details
    In: BMC Genomics, Springer Science and Business Media LLC, Vol. 23, No. 1 ( 2022-12-06)
    Abstract: Different types of skeletal myofibers exhibit distinct physiological and metabolic properties that are associated with meat quality traits in livestock. Alternative splicing (AS) of pre-mRNA can generate multiple transcripts from an individual gene by differential selection of splice sites. N6-methyladenosine (m6A) is the most abundant modification in mRNAs, but its regulation for AS in different muscles remains unknown.  Results We characterized AS events and m6A methylation pattern in pig oxidative and glycolytic muscles. A tota1 of 1294 differential AS events were identified, and differentially spliced genes were significantly enriched in processes related to different phenotypes between oxidative and glycolytic muscles. We constructed the regulatory network between splicing factors and corresponding differential AS events and identified NOVA1 and KHDRBS2 as key splicing factors. AS event was enriched in m6A-modified genes, and the methylation level was positively correlated with the number of AS events in genes. The dynamic change in m6A enrichment was associated with 115 differentially skipping exon (SE-DAS) events within 92 genes involving in various processes, including muscle contraction and myofibril assembly. We obtained 23.4% SE-DAS events (27/115) regulated by METTL3-meditaed m6A and experimentally validated the aberrant splicing of ZNF280D, PHE4DIP, and NEB. The inhibition of m6A methyltransferase METTL3 could induce the conversion of oxidative fiber to glycolytic fiber in PSCs. Conclusion Our study suggested that m6A modification could contribute to significant difference in phenotypes between oxidative and glycolytic muscles by mediating the regulation of AS. These findings would provide novel insights into mechanisms underlying muscle fiber conversion.
    Type of Medium: Online Resource
    ISSN: 1471-2164
    URL: Article
    DOI: 10.1186/s12864-022-09043-0
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2041499-7
    SSG: 12
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  • 7
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    The Outbreak, direction and guidance of sentiment: an Analysis of COVID-19 public sentiment in China
    Univ. of Malaya ; 2022
    In:  Jurnal Pengajian Media Malaysia Vol. 24, No. 2 ( 2022-1-12), p. 97-116
    Details
    In: Jurnal Pengajian Media Malaysia, Univ. of Malaya, Vol. 24, No. 2 ( 2022-1-12), p. 97-116
    Abstract: Since the end of 2019, the COVID-19 epidemic broke out suddenly and spread rapidly around the world. This sudden disease has seriously affected the conventional social system, especially after the media have been controlled, people cannot get sufficient and correct information, at the same time, rumors have spread widely and rapidly on the Internet, these factors led to public panic. Based on the Situational Crisis Communication Theory (SCCT), we analyze 554 comments of users in the two WeChat official accounts of Caixin and the Beijing News during the period of COVID-19, exploring the relationship between public sentiment and crisis type. The findings reveal the characteristics of crisis events causing public sentiment under different attribution types and form a preliminary model of crisis emotion guidance.
    Type of Medium: Online Resource
    ISSN: 1511-2284 , 2231-8143
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.22452/jpmm.vol24no2
    DOI: 10.22452/jpmm
    DOI: 10.22452/jpmm.vol24no2.6
    Language: Unknown
    Publisher: Univ. of Malaya
    Publication Date: 2022
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  • 8
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    Online Resource
    Data_Sheet_1.pdf
    Frontiers Media SA ; 2022
    In:  Frontiers in Medicine Vol. 9 ( 2022-4-27)
    Details
    In: Frontiers in Medicine, Frontiers Media SA, Vol. 9 ( 2022-4-27)
    Abstract: Emergency endoscopy is recommended for patients with acute esophageal variceal bleeding (EVB) and their prognosis has improved markedly over past decades due to the increased specialization of endoscopic practice. The study aimed to compare outcomes following emergency endoscopic injection sclerotherapy (EIS) and endoscopic variceal ligation (EVL) in cirrhotic patients with acute EVB. Methods Cirrhotic patients with acute EVB who underwent emergency endoscopy were retrospectively enrolled from 2013 to 2020 across 34 university hospitals from 30 cities. The primary outcome was the incidence of 5-day rebleeding after emergency endoscopy. Subgroup analysis was stratified by Child-Pugh class and bleeding history. A 1:1 propensity score matching (PSM) analysis was performed. Results A total of 1,017 and 382 patients were included in EIS group and EVL group, respectively. The 5-day rebleeding incidence was similar between EIS group and EVL group (4% vs. 5%, P = 0.45). The result remained the same after PSM ( P = 1.00). Among Child-Pugh class A, B and C patients, there were no differences in the 5-day rebleeding incidence between the two groups after PSM ( P = 0.25, 0.82, and 0.21, respectively). As for the patients with or without bleeding history, the differences between EIS group and EVL group were not significant after PSM ( P = 1.00 and 0.26, respectively). Conclusion The nationwide cohort study indicates that EIS and EVL are both efficient emergency endoscopic treatment strategies for acute EVB. EIS should not be dismissed as an economical and effective emergency endoscopic treatment strategy of acute EVB. ClincialTrials.gov number NCT04307264.
    Type of Medium: Online Resource
    ISSN: 2296-858X
    URL: Article
    URL: Article
    DOI: 10.3389/fmed.2022.872881
    DOI: 10.3389/fmed.2022.872881.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2775999-4
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  • 9
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    Traditional Chinese Medicine Recognition Based on Target Detection
    Hindawi Limited ; 2022
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2022 ( 2022-7-8), p. 1-9
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2022 ( 2022-7-8), p. 1-9
    Abstract: Traditional Chinese medicine (TCM) is widely used in China, but the large variety can easily lead to difficulties in visual identification. This study aims to evaluate the availability of target detection models to identify TCMs. We have collected images of 100 common TCMs in pharmacies, and use three current mainstream target detection models: Faster RCNN, SSD, and YOLO v5 to train the TCM dataset. By comparing the metrics of the three models, the results show that the YOLO v5 model has obvious advantages in the recognition of a variety of TCM, the mean average accuracy of the YOLO v5 is 94.33% and the FPS has reached 75, this model has a smaller number of parameters and solves the problem of detection and occlusion for small targets. Our experiments prove that the target detection technology has broad application prospects in the detection of TCM.
    Type of Medium: Online Resource
    ISSN: 1741-4288 , 1741-427X
    URL: Article
    DOI: 10.1155/2022/9220443
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2148302-4
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  • 10
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    Integrated Analysis of DNA Methylation and Gene Expression in Porcine Placental Development
    MDPI AG ; 2023
    In:  International Journal of Molecular Sciences Vol. 24, No. 6 ( 2023-03-08), p. 5169-
    Details
    In: International Journal of Molecular Sciences, MDPI AG, Vol. 24, No. 6 ( 2023-03-08), p. 5169-
    Abstract: Proper placental development is crucial for the conceptus to grow and survive, because the placenta is responsible for transporting nutrients and oxygen from the pregnant female to the developing fetus. However, the processes of placental morphogenesis and fold formation remain to be fully elucidated. In this study, we used whole-genome bisulfite sequencing and RNA sequencing to produce a global map of DNA methylation and gene expression changes in placentas from Tibetan pig fetuses 21, 28, and 35 days post-coitus. Substantial changes in morphology and histological structures at the uterine–placental interface were revealed via hematoxylin–eosin staining. Transcriptome analysis identified 3959 differentially expressed genes (DEGs) and revealed the key transcriptional properties in three stages. The DNA methylation level in the gene promoter was negatively correlated with gene expression. We identified a set of differentially methylated regions associated with placental developmental genes and transcription factors. The decrease in DNA methylation level in the promoter was associated with the transcriptional activation of 699 DEGs that were functionally enriched in cell adhesion and migration, extracellular matrix remodeling, and angiogenesis. Our analysis provides a valuable resource for understanding the mechanisms of DNA methylation in placental development. The methylation status of different genomic regions plays a key role in establishing transcriptional patterns from placental morphogenesis to fold formation.
    Type of Medium: Online Resource
    ISSN: 1422-0067
    URL: Article
    DOI: 10.3390/ijms24065169
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2019364-6
    SSG: 12
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