In:
Frontiers in Pharmacology, Frontiers Media SA, Vol. 13 ( 2022-10-21)
Abstract:
Previous studies have shown that matrine, a natural compound extracted from the herb Sophora flavescens , has a good anti-leukemia effect, but its key target and mechanism remains unclear. Here, we found that only c-Myc could respond rapidly to matrine treatment in three myeloid leukemia cell lines, and matrine inhibited both transcription and translation of c-Myc. Ribosome biogenesis and nucleotide metabolism, the key downstream of c-Myc, were significantly suppressed after matrine treatment. Therefore, our results confirmed that matrine is a special c-Myc inhibitor which suppresses ribosome biogenesis and nucleotide metabolism by inhibiting c-Myc in myeloid leukemia. This study provides scientific basis for the development of matrine derivatives to c-Myc-driven cancers.
Type of Medium:
Online Resource
ISSN:
1663-9812
DOI:
10.3389/fphar.2022.1027441
DOI:
10.3389/fphar.2022.1027441.s001
DOI:
10.3389/fphar.2022.1027441.s002
DOI:
10.3389/fphar.2022.1027441.s003
DOI:
10.3389/fphar.2022.1027441.s004
DOI:
10.3389/fphar.2022.1027441.s005
DOI:
10.3389/fphar.2022.1027441.s006
DOI:
10.3389/fphar.2022.1027441.s007
DOI:
10.3389/fphar.2022.1027441.s008
DOI:
10.3389/fphar.2022.1027441.s009
DOI:
10.3389/fphar.2022.1027441.s010
DOI:
10.3389/fphar.2022.1027441.s011
DOI:
10.3389/fphar.2022.1027441.s012
DOI:
10.3389/fphar.2022.1027441.s013
DOI:
10.3389/fphar.2022.1027441.s014
DOI:
10.3389/fphar.2022.1027441.s015
DOI:
10.3389/fphar.2022.1027441.s016
DOI:
10.3389/fphar.2022.1027441.s017
DOI:
10.3389/fphar.2022.1027441.s018
DOI:
10.3389/fphar.2022.1027441.s019
DOI:
10.3389/fphar.2022.1027441.s020
Language:
Unknown
Publisher:
Frontiers Media SA
Publication Date:
2022
detail.hit.zdb_id:
2587355-6
SSG:
15,3
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