In:
PLOS Pathogens, Public Library of Science (PLoS), Vol. 19, No. 7 ( 2023-7-20), p. e1011510-
Abstract:
Microsporidia are a large phylum of intracellular parasites that can infect most types of animals. Species in the Nematocida genus can infect nematodes including Caenorhabditis elegans , which has become an important model to study mechanisms of microsporidia infection. To understand the genomic properties and evolution of nematode-infecting microsporidia, we sequenced the genomes of nine species of microsporidia, including two genera, Enteropsectra and Pancytospora , without any previously sequenced genomes. Core cellular processes, including metabolic pathways, are mostly conserved across genera of nematode-infecting microsporidia. Each species encodes unique proteins belonging to large gene families that are likely used to interact with host cells. Most strikingly, we observed one such family, NemLGF1, is present in both Nematocida and Pancytospora species, but not any other microsporidia. To understand how Nematocida phenotypic traits evolved, we measured the host range, tissue specificity, spore size, and polar tube length of several species in the genus. Our phylogenetic analysis shows that Nematocida is composed of two groups of species with distinct traits and that species with longer polar tubes infect multiple tissues. Together, our work details both genomic and trait evolution between related microsporidia species and provides a useful resource for further understanding microsporidia evolution and infection mechanisms.
Type of Medium:
Online Resource
ISSN:
1553-7374
DOI:
10.1371/journal.ppat.1011510
DOI:
10.1371/journal.ppat.1011510.g001
DOI:
10.1371/journal.ppat.1011510.g002
DOI:
10.1371/journal.ppat.1011510.g003
DOI:
10.1371/journal.ppat.1011510.g004
DOI:
10.1371/journal.ppat.1011510.g005
DOI:
10.1371/journal.ppat.1011510.g006
DOI:
10.1371/journal.ppat.1011510.g007
DOI:
10.1371/journal.ppat.1011510.s001
DOI:
10.1371/journal.ppat.1011510.s002
DOI:
10.1371/journal.ppat.1011510.s003
DOI:
10.1371/journal.ppat.1011510.s004
DOI:
10.1371/journal.ppat.1011510.s005
DOI:
10.1371/journal.ppat.1011510.s006
DOI:
10.1371/journal.ppat.1011510.s007
DOI:
10.1371/journal.ppat.1011510.s008
DOI:
10.1371/journal.ppat.1011510.s009
DOI:
10.1371/journal.ppat.1011510.s010
DOI:
10.1371/journal.ppat.1011510.s011
DOI:
10.1371/journal.ppat.1011510.s012
DOI:
10.1371/journal.ppat.1011510.s013
DOI:
10.1371/journal.ppat.1011510.s014
DOI:
10.1371/journal.ppat.1011510.s015
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10.1371/journal.ppat.1011510.s016
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10.1371/journal.ppat.1011510.s017
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10.1371/journal.ppat.1011510.s018
DOI:
10.1371/journal.ppat.1011510.s019
DOI:
10.1371/journal.ppat.1011510.s020
DOI:
10.1371/journal.ppat.1011510.s021
DOI:
10.1371/journal.ppat.1011510.s022
DOI:
10.1371/journal.ppat.1011510.s023
DOI:
10.1371/journal.ppat.1011510.s024
DOI:
10.1371/journal.ppat.1011510.s025
DOI:
10.1371/journal.ppat.1011510.s026
DOI:
10.1371/journal.ppat.1011510.s027
DOI:
10.1371/journal.ppat.1011510.r001
DOI:
10.1371/journal.ppat.1011510.r002
DOI:
10.1371/journal.ppat.1011510.r003
DOI:
10.1371/journal.ppat.1011510.r004
DOI:
10.1371/journal.ppat.1011510.r005
DOI:
10.1371/journal.ppat.1011510.r006
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2023
detail.hit.zdb_id:
2205412-1
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