In:
Angewandte Chemie, Wiley, Vol. 129, No. 15 ( 2017-04-03), p. 4302-4306
Abstract:
A 3,7‐diazabicyclo[3.3.1]nonane linking to two melamines is a unique transmembrane H + /Cl − carrier. In the solid state, the V‐shaped compound forms a HCl‐bound zig‐zag network through cooperative protonation and hydrogen bond interactions. In the lipid membrane, the receptor forms a dimeric self‐assembly involving multiple H + and Cl − leading to the efficient transport of the acid. The pH‐dependent Cl − efflux observed for the compound was rationalized based on a gradual protonation model that confers an active transmembrane carrier at physiological pH.
Type of Medium:
Online Resource
ISSN:
0044-8249
,
1521-3757
DOI:
10.1002/ange.v129.15
DOI:
10.1002/ange.201700803
Language:
English
Publisher:
Wiley
Publication Date:
2017
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514305-6
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505872-7
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1479266-7
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506259-7
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