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  • 1
    Online Resource
    Online Resource
    MDPI AG ; 2022
    In:  Energies Vol. 15, No. 17 ( 2022-08-31), p. 6365-
    In: Energies, MDPI AG, Vol. 15, No. 17 ( 2022-08-31), p. 6365-
    Abstract: The use of fossil energy sources has a negative impact on the economic and socio-political stability of specific regions and countries, causing environmental changes due to the emission of greenhouse gases. Moreover, the stocks of mineral energy are limited, causing the demand for new types and forms of energy. Biomass is a renewable energy source and represents an alternative to fossil energy sources. Microorganisms produce energy from the substrate and biomass, i.e., from substances in the microenvironment, to maintain their metabolism and life. However, specialized microorganisms also produce specific metabolites under almost abiotic circumstances that often do not have the immediate task of sustaining their own lives. This paper presents the action of biogenic and biogenic–thermogenic microorganisms, which produce methane, alcohols, lipids, triglycerides, and hydrogen, thus often creating renewable energy from waste biomass. Furthermore, some microorganisms acquire new or improved properties through genetic interventions for producing significant amounts of energy. In this way, they clean the environment and can consume greenhouse gases. Particularly suitable are blue-green algae or cyanobacteria but also some otherwise pathogenic microorganisms (E. coli, Klebsiella, and others), as well as many other specialized microorganisms that show an incredible ability to adapt. Microorganisms can change the current paradigm, energy–environment, and open up countless opportunities for producing new energy sources, especially hydrogen, which is an ideal energy source for all systems (biological, physical, technological). Developing such energy production technologies can significantly change the already achieved critical level of greenhouse gases that significantly affect the climate.
    Type of Medium: Online Resource
    ISSN: 1996-1073
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2437446-5
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  • 2
    Online Resource
    Online Resource
    MDPI AG ; 2023
    In:  Energies Vol. 16, No. 8 ( 2023-04-07), p. 3321-
    In: Energies, MDPI AG, Vol. 16, No. 8 ( 2023-04-07), p. 3321-
    Abstract: Hydrogen is widely considered as the fuel of the future. Due to the challenges present during hydrogen production using conventional processes and technologies, additional methods must be considered, like the use of microorganisms. One of the most promising technologies is dark fermentation, a process where microorganisms are utilized to produce hydrogen from biomass. The paper provides a comprehensive overview of the biological processes of hydrogen production, specifically emphasizing the dark fermentation process. This kind of fermentation involves bacteria, such as Clostridium and Enterobacterium, to produce hydrogen from organic waste. Synthetic microbial consortia are also discussed for hydrogen production from different types of biomasses, including lignocellulosic biomass, which includes all biomass composed of lignin and (hemi)cellulose, sugar-rich waste waters, and others. The use of genetic engineering to improve the fermentation properties of selected microorganisms is also considered. Finally, the paper covers the important aspect of hydrogen management, including storage, transport, and economics.
    Type of Medium: Online Resource
    ISSN: 1996-1073
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2437446-5
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  • 3
    In: Microbial Drug Resistance, Mary Ann Liebert Inc, Vol. 25, No. 5 ( 2019-06), p. 696-702
    Type of Medium: Online Resource
    ISSN: 1076-6294 , 1931-8448
    Language: English
    Publisher: Mary Ann Liebert Inc
    Publication Date: 2019
    detail.hit.zdb_id: 2030467-5
    SSG: 15,3
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  • 4
    In: Biology, MDPI AG, Vol. 11, No. 1 ( 2021-12-24), p. 20-
    Abstract: Metabolic syndrome (MetS) is a combination of cardiovascular risk factors associated with type 2 diabetes, obesity, and cardiovascular diseases. The circadian clock gene polymorphisms are very likely to participate in metabolic syndrome genesis and development. However, research findings of the association between circadian rhythm gene polymorphisms and MetS and its comorbidities are not consistent. In this study, a review of the association of circadian clock gene polymorphisms with overall MetS risk was performed. In addition, a meta-analysis was performed to clarify the association between circadian clock gene polymorphisms and MetS susceptibility based on available data. The PubMed and Scopus databases were searched for studies reporting the association between circadian rhythm gene polymorphisms (ARNTL, BMAL1, CLOCK, CRY, PER, NPAS2, REV-ERBα, REV-ERBβ, and RORα) and MetS, and its comorbidities diabetes, obesity, and hypertension. Thirteen independent studies were analyzed with 17,381 subjects in total. The results revealed that the BMAL1 rs7950226 polymorphism was associated with an increased risk of MetS in the overall population. In contrast, the CLOCK rs1801260 and rs6850524 polymorphisms were not associated with MetS. This study suggests that some circadian rhythm gene polymorphisms might be associated with MetS in different populations and potentially used as predictive biomarkers for MetS.
    Type of Medium: Online Resource
    ISSN: 2079-7737
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2661517-4
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  • 5
    In: Microorganisms, MDPI AG, Vol. 10, No. 2 ( 2022-01-24), p. 255-
    Abstract: Legionella pneumophila is defined as a bacterium that can cause severe pneumonia. It is found in the natural environment and in water, and is often found in water tanks. It can be an integral part of biofilms in nature, and the protozoa in which it can live provide it with food and protect it from harmful influences; therefore, it has the ability to move into a sustainable but uncultured state (VBNC). L. pneumophila has been shown to cause infections in dental practices. The most common transmission route is aerosol generated in dental office water systems, which can negatively affect patients and healthcare professionals. The most common way of becoming infected with L. pneumophila in a dental office is through water from dental instruments, and the dental unit. In addition to these bacteria, patients and the dental team may be exposed to other harmful bacteria and viruses. Therefore, it is vital that the dental team regularly maintains and decontaminates the dental unit, and sterilizes all accessories that come with it. In addition, regular water control in dental offices is necessary.
    Type of Medium: Online Resource
    ISSN: 2076-2607
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2720891-6
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  • 6
    In: Biomedicines, MDPI AG, Vol. 10, No. 12 ( 2022-12-04), p. 3130-
    Abstract: Recently, it was found that when confronted with major vessel occlusion and vascular failure, stable gastric pentadecapeptide BPC 157 therapy might rapidly functionally improve minor vessels to take over the function of disabled major vessels, reorganize blood flow, and compensate failed vessel function. We focused on the BPC 157 therapy effect obtained by giving 10 ng/kg ip to rats 5 min before sacrifice on the rat thoracic aorta, which we assessed with Fourier transform infrared spectroscopy (FTIR) 90 min thereafter. We applied a principal component analysis (PCA). The PCA model showed, with a clear distinction being mostly due to the PC1 score, differences between the spectra of BPC 157- and saline-treated rats. The comparison of the averaged spectra of these two groups with their differential spectrum and PC loadings allowed us to identify the parts of the FTIR spectra that contributed the most to the spectral separation of the two observed groups. The PC1 loadings and the differential spectrum showed that the main bands affecting the separation were the amid I band around 1650 cm−1, the amid II band around 1540 cm−1, and the vibrational band around 1744 cm−1. Fitting the spectral range between 1450 and 1800 cm−1 showed changes in protein conformation and confirmed the appearance of the vibrational band at 1744 cm−1. Controls had a substantially more intense vibrational band at 1744 cm−1. These spectral results showed the cells from saline-treated (control) rats to be in the early stage of cell death, while the samples from BPC 157-rats were protected. Thus, BPC 157 therapy changed the lipid contents and protein secondary structure conformation, with a rapid effect on vessels, within a short time upon application.
    Type of Medium: Online Resource
    ISSN: 2227-9059
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2720867-9
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  • 7
    In: Microorganisms, MDPI AG, Vol. 10, No. 12 ( 2022-12-05), p. 2405-
    Abstract: The gut microbiota, which represent a community of different microorganisms in the human intestinal tract, are crucial to preserving human health by participating in various physiological functions and acting as a metabolic organ. In physiological conditions, microbiota–host partnership exerts homeostatic stability; however, changes in intestinal microbiota composition (dysbiosis) are an important factor in the pathogenesis of inflammatory bowel disease and its two main disease entities: ulcerative colitis and Crohn’s disease. The incidence and prevalence of these inflammatory conditions have increased rapidly in the last decade, becoming a significant problem for the healthcare system and a true challenge in finding novel therapeutic solutions. The issue is that, despite numerous studies, the etiopathogenesis of inflammatory bowel disease is not completely clear. Based on current knowledge, chronic intestinal inflammation occurs due to altered intestinal microbiota and environmental factors, as well as a complex interplay between the genetic predisposition of the host and an inappropriate innate and acquired immune response. It is important to note that the development of biological and immunomodulatory therapy has led to significant progress in treating inflammatory bowel disease. Certain lifestyle changes and novel approaches—including fecal microbiota transplantation and nutritional supplementation with probiotics, prebiotics, and synbiotics—have offered solutions for dysbiosis management and paved the way towards restoring a healthy microbiome, with only minimal long-term unfavorable effects.
    Type of Medium: Online Resource
    ISSN: 2076-2607
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2720891-6
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  • 8
    Online Resource
    Online Resource
    University of Rijeka, Faculty of Medicine ; 2023
    In:  Medicina Fluminensis Vol. 59, No. 2 ( 2023-06-01), p. 161-169
    In: Medicina Fluminensis, University of Rijeka, Faculty of Medicine, Vol. 59, No. 2 ( 2023-06-01), p. 161-169
    Abstract: Aim: This study aimed to examine the association of ABO and RhD blood groups with COVID-19 mortality of patients hospitalized in the COVID ward at General Hospital Karlovac. Participants and methods: The study included data about 778 patients with COVID-19 hospitalized in the COVID ward at General Hospital Karlovac from March 2020 to the end of December 2021. Data about the hospitalized patients’ age, sex, blood groups, RhD status, comorbidities, oxygen, respirator use, vaccination, and disease course and outcome were obtained from the Hospital Management System. Furthermore, the association of ABO and RhD blood groups with the number of days in the hospital and the mortality rate was examined. Results: The prevalent blood group was O, with 283 patients (36.4%), while the A blood group was the second most common (35.8%). The least common blood group was AB (7.6%). At the time of hospitalization, a small number of patients had been vaccinated, only 8.1%. The overall COVID-19-associated mortality of 25.9% was observed. The mortality rate was 39.7% in blood group A, 24.2% in group B, 23.7% in group AB and 23.7% in group O (P = 0.588). The mortality rate from the COVID-19 disease was higher in RhD-positive (26.4%) compared to RhD-negative individuals (23.7%). The largest number of patients on a respirator (16.5%) were A blood group. Conclusion: The study did not find a significant association between the ABO and RhD blood group and the COVID-19 severity and mortality among patients hospitalized in the COVID ward at General Hospital Karlovac.
    Type of Medium: Online Resource
    ISSN: 1848-820X , 1847-6864
    Language: Unknown
    Publisher: University of Rijeka, Faculty of Medicine
    Publication Date: 2023
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  • 9
    Online Resource
    Online Resource
    MDPI AG ; 2023
    In:  Clocks & Sleep Vol. 5, No. 2 ( 2023-05-15), p. 295-312
    In: Clocks & Sleep, MDPI AG, Vol. 5, No. 2 ( 2023-05-15), p. 295-312
    Abstract: This article provides an overview of how sleep and circadian rhythm disturbances mutually influence the occurrence of dental caries and how it is possible to reduce the risk of circadian rhythm disturbances, sleep, and associated adverse effects. Dental caries is a global problem worldwide that contributes to sociological limitations. Numerous factors influence the occurrence of dental caries, from socioeconomic factors to cariogenic bacteria, dietary habits, and oral hygiene. However, sleep disorders and circadian rhythm disturbances represent a new approach in the fight against the increasing prevalence of dental caries worldwide. Bacteria in the oral cavity and the oral microbiome are mainly responsible for the development of caries, and saliva plays an important role in their regulation. The circadian rhythm regulates numerous physiological functions, including sleep and saliva production. Disturbances in sleep and circadian rhythms affect saliva production, which impacts the development of dental caries, as saliva is necessary for regulating and maintaining oral health, especially for controlling oral infections. A person’s preference for a particular time of day depends on the circadian rhythm called chronotype. Individuals with an evening chronotype have a less healthy lifestyle that can lead to a higher caries risk than individuals with a morning chronotype. Because circadian rhythms are critical to maintaining sleep homeostasis and oral health, sleep disturbances can disrupt circadian rhythms and lead to a vicious cycle.
    Type of Medium: Online Resource
    ISSN: 2624-5175
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2966788-4
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  • 10
    In: Endocrine Abstracts, Bioscientifica, ( 2024-05-06)
    Type of Medium: Online Resource
    ISSN: 1479-6848
    Language: Unknown
    Publisher: Bioscientifica
    Publication Date: 2024
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