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  • 1
    In: Pediatrics, American Academy of Pediatrics (AAP), Vol. 108, No. 2 ( 2001-08-01), p. 239-247
    Abstract: In 1995, & gt;5 million episodes of acute otitis media (AOM) accounted for $3 billion in health care expenditures. Objectives. To synthesize the literature on the natural history of AOM, the effectiveness of antibiotic treatment in uncomplicated AOM, and the relative effectiveness of specific antibiotic regimens. Data Sources. Seven electronic databases for articles published between 1966 and March 1999 and reference lists in proceedings, published articles, reports, and guidelines. Study Selection. Two physicians independently assessed each article. Studies addressing AOM in children 4 weeks to 18 years old were included; those addressing children with immunodeficiencies or craniofacial abnormalities were excluded. Randomized, controlled trials (RCTs) were used to assess antibiotic effectiveness, and RCTs and cohort studies were used to assess the natural history of AOM. Among the 3491 citations identified, 80 (2.3%) met our inclusion criteria. Data Extraction. Two physicians independently abstracted data and assessed the quality of studies using a validated scale for RCTs and 8 quality components for cohort studies. Data Synthesis. Random-effects estimates of pooled absolute rate differences of outcomes were derived, and heterogeneity of both the rates and rate differences was assessed. Children with AOM not treated with antibiotics experienced a 1- to 7-day clinical failure rate of 19% (95% confidence interval: 0.10–0.28) and few suppurative complications. When patients were treated with amoxicillin, the 2- to 7-day clinical failure rate was reduced to 7%, a 12% (95% confidence interval: 0.04–0.20) reduction. Adverse effects, primarily gastrointestinal, were more common among children on cefixime than among those on ampicillin or amoxicillin. They were also more common among children on amoxicillin-clavulanate than among those on azithromycin. Conclusions. The majority of uncomplicated cases of AOM resolve spontaneously without apparent suppurative complications. Ampicillin or amoxicillin confers a limited therapeutic benefit. There is no evidence to support any particular antibiotic regimens as more effective at relieving symptoms. Certain antibiotics are more likely than others to cause diarrhea and other adverse events.
    Type of Medium: Online Resource
    ISSN: 1098-4275 , 0031-4005
    Language: English
    Publisher: American Academy of Pediatrics (AAP)
    Publication Date: 2001
    detail.hit.zdb_id: 1477004-0
    detail.hit.zdb_id: 207677-9
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  • 2
    Online Resource
    Online Resource
    American Academy of Pediatrics (AAP) ; 2001
    In:  Pediatrics Vol. 108, No. 2 ( 2001-08-01), p. 248-254
    In: Pediatrics, American Academy of Pediatrics (AAP), Vol. 108, No. 2 ( 2001-08-01), p. 248-254
    Abstract: To report research gaps and priorities of future research identified during an evidence assessment process on the management of acute otitis media (AOM). Methods. A conceptual framework for management of AOM was developed to guide the evidence assessment. An 11-member technical expert panel guided the selection of key questions, prioritization of influencing factors, development of scope, definition of AOM, and search strategy through polling processes and conference calls. Quality of clinical trials was evaluated using established scales. Outcome measures were abstracted from each study. Results. A total of 3461 titles and abstracts were screened, and 760 full-length articles were reviewed. Of the 760 articles, 80 studies addressed the key questions. In defining AOM, 42 (52.5%) of the 80 studies included the middle-ear effusion component, only 2 (2.5%) included the rapid onset component, and 26 (32.5%) included the signs/symptoms of inflammation component. None of the 80 studies used all 3 components. Of the 74 controlled trials, 39 (53%) were of acceptable quality (Jadad score of 3 or higher). The technical experts did not agree in the ranking of the importance of the 41 influencing factors (Kendall's coefficient of concordance was 0.0022). Another poll also indicated diverse opinions of the experts on the importance of 7 key questions derived from the conceptual framework (Kendall coefficient of concordance is 0.21). Furthermore, our review found that the type and definition of outcome measure varied. Conclusions. Despite the large body of literature on AOM, its quality is uneven and its findings are not generalizable. Future research should try to answer all key questions and investigate all risk factors in well-designed, scientific studies.
    Type of Medium: Online Resource
    ISSN: 1098-4275 , 0031-4005
    Language: English
    Publisher: American Academy of Pediatrics (AAP)
    Publication Date: 2001
    detail.hit.zdb_id: 1477004-0
    detail.hit.zdb_id: 207677-9
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  • 3
    In: JAMA, American Medical Association (AMA), Vol. 304, No. 19 ( 2010-11-17), p. 2161-
    Type of Medium: Online Resource
    ISSN: 0098-7484
    RVK:
    Language: English
    Publisher: American Medical Association (AMA)
    Publication Date: 2010
    detail.hit.zdb_id: 2958-0
    SSG: 5,21
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  • 4
    In: Pediatrics, American Academy of Pediatrics (AAP), Vol. 112, No. 6 ( 2003-12-01), p. 1379-1387
    Abstract: Objectives. We report the findings of an evidence assessment on the accuracy of methods of diagnosing middle ear effusion in children with otitis media with effusion (OME). Methods. We searched Medline (1966–January 2000), the Cochrane Library (through January 2000), and Embase (1980–January 2000) and identified additional articles from reference lists in proceedings, published articles, reports, and guidelines. Excluded were nonhuman studies; case reports; editorials; letters; reviews; practice guidelines; non–English-language publications; and studies on patients with immunodeficiencies, craniofacial anomalies (including cleft palate), primary mucosal disorders, or genetic conditions. From each eligible study, we calculated the sensitivity, specificity, positive predictive value, negative predictive value, accuracy, and prevalence of OME in the cohort. We determined the number of studies for each comparison of a diagnostic method and a reference standard listed within the scope of our assessment. For comparisons with 3 or more studies, we derived random effects estimates of sensitivity, specificity, and prevalence rate. Using the pooled estimates, we plotted the performance of each diagnostic test in terms of sensitivity and (1 − specificity) and identified the best performer among the tests included in the comparison. Results. Among 8 diagnostic methods, pneumatic otoscopy had the best apparent performance with a sensitivity of 94% (95% confidence interval: 92%–96%) and a specificity of 80% (95% confidence interval: 75%–86%). However, examiner qualifications were reported inconsistently, and training was not specified. Conclusions. The finding that pneumatic otoscopy can do as well as or better than tympanometry and acoustic reflectometry has significant practical implications. For the typical clinician, pneumatic otoscopy should be easier to use than other diagnostic methods. The important question may be what degree of training will be needed for the clinician to be as effective with pneumatic otoscopy as were the examiners in the studies reviewed in this report.
    Type of Medium: Online Resource
    ISSN: 0031-4005 , 1098-4275
    Language: English
    Publisher: American Academy of Pediatrics (AAP)
    Publication Date: 2003
    detail.hit.zdb_id: 1477004-0
    detail.hit.zdb_id: 207677-9
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  • 5
    Online Resource
    Online Resource
    Daedalus Enterprises ; 2019
    In:  Respiratory Care Vol. 64, No. 12 ( 2019-12), p. 1461-1468
    In: Respiratory Care, Daedalus Enterprises, Vol. 64, No. 12 ( 2019-12), p. 1461-1468
    Type of Medium: Online Resource
    ISSN: 0020-1324 , 1943-3654
    RVK:
    Language: English
    Publisher: Daedalus Enterprises
    Publication Date: 2019
    detail.hit.zdb_id: 2106236-5
    detail.hit.zdb_id: 603252-7
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  • 6
    In: Pediatrics, American Academy of Pediatrics (AAP), Vol. 122, No. 4 ( 2008-10-01), p. e861-e866
    Abstract: OBJECTIVES. Narcotic-related adverse drug events are the most common adverse drug events in hospitalized children. Despite multiple published studies describing interventions that decrease adverse drug events from narcotics, large-scale collaborative quality improvement efforts to address narcotic-related adverse drug events in pediatrics have not been described. The purpose of this study was to evaluate collaborative-wide narcotic-related adverse drug event rates after a collection of expert panel–defined best practices was implemented. METHODS. All 42 children's hospitals in the Child Health Corporation of America were invited to participate in the Institute for Healthcare Improvement–style quality improvement collaborative aimed at reducing narcotic-related adverse drug events. A collection of interventions known or suspected to reduce narcotic-related adverse drug events was recommended by an expert panel, with each site implementing ≥1 of these best practices on the basis of local need. Narcotic-related adverse drug event rates were compared between the baseline (December 1, 2004, to March 31, 2005) and postimplementation periods (January 1, 2006, to March 31, 2006) after an a priori–defined intervention ramp-up time (April 1, 2005, and December 31, 2005). Secondary outcome measures included constipation rates and narcotic-related automated drug-dispensing-device override percentages. RESULTS. Median narcotic-related adverse drug event rates decreased 67% between the baseline and postimplementation time frames across the 14-site collaborative. Constipation rates decreased 68.9%, and automated drug-dispensing-device overrides decreased from 10.18% to 5.91% of all narcotic doses administered. CONCLUSIONS. Implementation of ≥1 expert panel–recommended interventions at each participating site resulted in a significant decrease in narcotic-related adverse drug events, constipation, and automated drug-dispensing-device overrides in a 12-month, 14-site children's hospital quality collaborative.
    Type of Medium: Online Resource
    ISSN: 0031-4005 , 1098-4275
    Language: English
    Publisher: American Academy of Pediatrics (AAP)
    Publication Date: 2008
    detail.hit.zdb_id: 1477004-0
    detail.hit.zdb_id: 207677-9
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  • 7
    In: Pediatrics, American Academy of Pediatrics (AAP), Vol. 128, No. 2 ( 2011-08-01), p. e438-e445
    Abstract: Adverse drug events (ADEs) occur more frequently in pediatric patients than adults. ADEs frequently cause serious harm to children and increase the cost of care. The purpose of this study was to decrease ADEs by targeting the entire medication-delivery system for all high-risk medications. METHODS: Thirteen freestanding children's hospitals participated in this ADE collaborative. An advisory panel developed a change package of interventions that consisted of standardization of medication-ordering (eg, consensus-based protocols and order sets and high-alert medication protocols), reliable medication-dispensing processes (eg, automated dispensing cabinets and redesign of floor stock procedures), reliable medication-administration processes (eg, safe pump use and reducing interruptions), improvement of patient safety culture (eg, safety-culture changes and reduction of staff intimidation), and clinical decision support (eg, increase ADE detection and redesign care systems). ADE rates were compared from the 3-month baseline period to quarters of the 12-month intervention phase. ADE rates were categorized further as opioid related and other medication related. RESULTS: From baseline to the final quarter, the collaborative resulted in a 42% decrease in total ADEs, a 51% decrease in opioid-related ADEs, and a 41% decrease in other medication ADEs. CONCLUSION: A pediatric collaborative that targeted the medication-delivery system decreased the rate of ADEs at participating institutions.
    Type of Medium: Online Resource
    ISSN: 0031-4005 , 1098-4275
    Language: English
    Publisher: American Academy of Pediatrics (AAP)
    Publication Date: 2011
    detail.hit.zdb_id: 1477004-0
    detail.hit.zdb_id: 207677-9
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  • 8
    Online Resource
    Online Resource
    American Academy of Pediatrics (AAP) ; 2008
    In:  Pediatrics Vol. 121, No. 4 ( 2008-04-01), p. e927-e935
    In: Pediatrics, American Academy of Pediatrics (AAP), Vol. 121, No. 4 ( 2008-04-01), p. e927-e935
    Abstract: OBJECTIVES. The purposes of this study were to develop a pediatric-focused tool for adverse drug event detection and describe the incidence and characteristics of adverse drug events in children's hospitals identified by this tool. METHODS. A pediatric-specific trigger tool for adverse drug event detection was developed and tested. Eighty patients from each site were randomly selected for retrospective chart review. All adverse drug events identified using the trigger tool were evaluated for severity, preventability, ability to mitigate, ability to identify the event earlier, and presence of associated occurrence report. Each trigger and the entire tool were evaluated for positive predictive value. RESULTS. Review of 960 randomly selected charts from 12 children's hospitals revealed 2388 triggers (2.49 per patient) and 107 unique adverse drug events. Mean adverse drug event rates were 11.1 per 100 patients, 15.7 per 1000 patient-days, and 1.23 per 1000 medication doses. The positive predictive value of the trigger tool was 3.7%. Twenty-two percent of all adverse drug events were deemed preventable, 17.8% could have been identified earlier, and 16.8% could have been mitigated more effectively. Ninety-seven percent of the identified adverse drug events resulted in mild, temporary harm. Only 3.7% of adverse drug events were identified in existing hospital-based occurrence reports. The most common adverse drug events identified were pruritis and nausea, the most common medication classes causing adverse drug events were opioid analgesics and antibiotics, and the most common stages of the medication management process associated with preventable adverse drug events were monitoring and prescribing/ordering. CONCLUSIONS. Adverse drug event rates in hospitalized children are substantially higher than previously described. Most adverse drug events resulted in temporary harm, and 22% were classified as preventable. Only 3.7% were identified by using traditional voluntary reporting methods. Our pediatric-focused trigger tool is effective at identifying adverse drug events in inpatient pediatric populations.
    Type of Medium: Online Resource
    ISSN: 0031-4005 , 1098-4275
    Language: English
    Publisher: American Academy of Pediatrics (AAP)
    Publication Date: 2008
    detail.hit.zdb_id: 1477004-0
    detail.hit.zdb_id: 207677-9
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  • 9
    Online Resource
    Online Resource
    Elsevier BV ; 1994
    In:  Icarus Vol. 109, No. 1 ( 1994-05), p. 3-19
    In: Icarus, Elsevier BV, Vol. 109, No. 1 ( 1994-05), p. 3-19
    Type of Medium: Online Resource
    ISSN: 0019-1035
    Language: English
    Publisher: Elsevier BV
    Publication Date: 1994
    detail.hit.zdb_id: 1467991-7
    SSG: 16,12
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  • 10
    Online Resource
    Online Resource
    American Geophysical Union (AGU) ; 1994
    In:  Geophysical Research Letters Vol. 21, No. 14 ( 1994-07), p. 1551-1553
    In: Geophysical Research Letters, American Geophysical Union (AGU), Vol. 21, No. 14 ( 1994-07), p. 1551-1553
    Abstract: The visible optical power emitted from the expansion plumes from 0.4 and 2 km diameter fragments of Shoemaker‐Levy are expected to be, ∼25% and comparable to, the visible solar flux reflected from Jupiter, respectively, for several minutes, and could be easily observed by sensors on the Galileo spacecraft. Earth‐based observers can detect these plumes as these expand over the SW limb of Jupiter and come into earth view some minutes after impact!
    Type of Medium: Online Resource
    ISSN: 0094-8276 , 1944-8007
    Language: English
    Publisher: American Geophysical Union (AGU)
    Publication Date: 1994
    detail.hit.zdb_id: 2021599-X
    detail.hit.zdb_id: 7403-2
    SSG: 16,13
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