In:
Oncology, S. Karger AG, Vol. 79, No. 3-4 ( 2010), p. 273-277
Abstract:
〈 i 〉 Background: 〈 /i 〉 It is extremely difficult to bring about a complete cure of metastatic breast cancer: the purpose of treatment is to prolong the patient’s survival while maintaining their quality of life (QOL). The current retrospective study was conducted to find whether S-1, an orally administered 5-FU agent, can produce a therapeutic result in patients with recurrent metastatic breast cancer while maintaining their QOL. 〈 i 〉 Methods: 〈 /i 〉 Among the patients who were diagnosed at our institution to have recurrent metastatic breast cancer between November 2001 and December 2008, those who were treated with S-1 were selected and their records retrospectively reviewed. 〈 i 〉 Results: 〈 /i 〉 The analysis was conducted on 33 patients. The median number of regimens that these patients underwent was 2 (range 0–6). The overall response rate (ORR), clinical benefit rate (CBR), median time to treatment failure and overall survival were 30%, 42%, 152 days and 338 days, respectively. Among the 11 patients who were treated with S-1 in the first or the second line, ORR and CBR were 45.5 and 63.6%, respectively. Toxicity more than grade 3, leucopenia, neutropenia diarrhea, mucositis, and hand-foot syndrome were found in only 3%. 〈 i 〉 Conclusion: 〈 /i 〉 S-1 is well-tolerated by patients, promising a therapy while maintaining their QOL. When applied in the early stage of a disease in particular, the agent promises a very effective anti-tumor effect.
Type of Medium:
Online Resource
ISSN:
0030-2414
,
1423-0232
Language:
English
Publisher:
S. Karger AG
Publication Date:
2010
detail.hit.zdb_id:
1483096-6
detail.hit.zdb_id:
250101-6
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