In:
Hepatology Research, Wiley, Vol. 44, No. 13 ( 2014-12), p. 1277-1285
Abstract:
Much is unknown about the effect of 25‐hydroxyvitamin D 3 levels on the outcome of pegylated interferon/ribavirin ( PEG IFN / RBV ) therapy for hepatitis C virus‐related cirrhosis. The purpose of the present study was to analyze and elucidate factors, including 25‐hydroxyvitamin D 3 , that contribute to a sustained virological response ( SVR ) in patients with cirrhosis. Methods We analyzed whether 25‐hydroxyvitamin D 3 contributes to the response to PEG IFN / RBV therapy among 134 cirrhotic patients. Results SVR was achieved in 43 patients. The median 25‐hydroxyvitamin D 3 level was 20 ng/mL. Univariate analysis showed that the following factors contributed to SVR : low‐density lipoprotein cholesterol, albumin, 25‐hydroxyvitamin D 3 , core a.a.70 (a.a.70) substitutions, the number of mutations at the interferon sensitivity‐determining region and IL28B genotype. Multivariate analysis identified IL28B genotype and 25‐hydroxyvitamin D 3 as independent factors contributing to SVR . Subsequently, SVR rate was examined by using 25‐hydroxyvitamin D 3 and other important factors. The SVR rate was 51.8% in patients with core a.a.70 wild and ≥15 ng/mL of 25‐hydroxyvitamin D 3 , whereas the SVR rate was 7.1% in patients with core a.a.70 wild and 〈 15 ng/mL of 25‐hydroxyvitamin D 3 . The SVR rate was 56.9% in patients with IL28B major genotype and ≥15 ng/mL of 25‐hydroxyvitamin D 3 . Surprisingly, the SVR rate was 0% in patients with IL28B minor genotype and 〈 15 ng/mL of 25‐hydroxyvitamin D 3 . Conclusion IL28B genotype and 25‐hydroxyvitamin D 3 were identified as independent factors contributing to SVR . Stratified analyses according to core a.a.70 substitution and IL28B genotype suggested that 25‐hydroxyvitamin D 3 influences the outcome of PEG IFN / RBV therapy for cirrhosis.
Type of Medium:
Online Resource
ISSN:
1386-6346
,
1872-034X
DOI:
10.1111/hepr.2014.44.issue-13
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
2006439-1
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