In:
Experimental and Clinical Endocrinology & Diabetes, Georg Thieme Verlag KG, Vol. 130, No. 12 ( 2022-12), p. 767-772
Kurzfassung:
Introduction Advanced glycation end products (AGEs) are frequently
increased in the skin of subjects with type 2 diabetes mellitus (T2DM). This study aimed to examine the correlation of AGEs with cardiac autonomic neuropathy
(CAN) in T2DM. Methods To this aim, 132 participants (88 men) with a mean age of 64.57
years and a median T2DM duration of 14.5 years were included. Skin AGEs were measured with AGE reader mu connect (Diagnoptics) on the dominant arm (both
single and automated triplicate measurements). Diagnosis of CAN, sympathetic and parasympathetic nervous system impairment was based on the four standardised
cardiovascular reflex tests (CARTs). Results On a single measurement, AGEs were increased in subjects with vs.
those without CAN (3.20±0.74 vs. 2.66±0.66, p 〈 0.001). As
compared with normal results, AGEs were increased for each one of the 4 abnormal CARTs: Valsalva Ratio (3.36±0.67 vs. 2.66±0.72,
p=0.004), E/I ratio (3.01±0.72 vs. 2.53±0.68, p=0.001), 30:15 ratio (3.08±0.76 vs. 2.75±0.69,
p=0.011), postural hypotension (3.30±0.72 vs. 2.75±0.66, p 〈 0.001). Similar results were obtained for triplicate measurements. Discussion Among T2DM subjects, skin AGEs appear to increase in the
presence of CAN. This holds true both for sympathetic and parasympathetic nervous system impairment.
Materialart:
Online-Ressource
ISSN:
0947-7349
,
1439-3646
Sprache:
Englisch
Verlag:
Georg Thieme Verlag KG
Publikationsdatum:
2022
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