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  • 1
    Online Resource
    Online Resource
    BRD4 and PIN1 gene polymorphisms are associated with high pulse pressure risk in a southeastern Chinese population
    Springer Science and Business Media LLC ; 2020
    In:  BMC Cardiovascular Disorders Vol. 20, No. 1 ( 2020-12)
    Details
    In: BMC Cardiovascular Disorders, Springer Science and Business Media LLC, Vol. 20, No. 1 ( 2020-12)
    Abstract: BRD4 and PIN1 have been described to be involved in inflammation and vascular endothelial cell dysfunction, which in turn may increase pulse pressure. Hypothesis Genetic mutations within the BRD4 and PIN1 genes could affect the risk of high pulse pressure. Methods A total of four single nucleotide polymorphisms (SNPs) ( BRD4 : rs4808278; PIN1 : rs2233678, rs2287838, and rs2233682) were genotyped in a cohort of 666 hypertensive patients and 232 normotensive controls with Chinese Han origin. Generalized multifactor dimensionality reduction (GMDR) was used to screen the best interaction combination among the four SNPs within the BRD4 and PIN1 genes and diabetes. Logistic regression analysis was performed to calculate the odds ratio (ORs) (95% confidence interval (CI)) for the association between the four SNPs. Results Adjusted for age, weight, waist circumference, drinking, smoking, hypertension, and diabetes, high pulse pressure risk was significantly higher for carriers with the rs4808278-TT genotype in BRD4 than those with wild genotypes (OR: 0.400, 95% CI: 0.217–0.737, P *  〈  0.05). However, we did not find any significant association of rs2233678, rs2287838, and rs2233682 in PIN1 with high pulse pressure susceptibility after covariate adjustment. GMDR analysis indicated a significant three-locus model ( P  = 0.0107) involving rs4808278, rs2233678, and diabetes, the cross-validation consistency of the three-locus models was 9/10, and the testing accuracy was 57.47%. Conclusions Genetic mutations within BRD4 (rs4808278) could affect the susceptibility to high pulse pressure in a southeastern Chinese population.
    Type of Medium: Online Resource
    ISSN: 1471-2261
    URL: Article
    DOI: 10.1186/s12872-020-01757-x
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 2059859-2
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  • 2
    Online Resource
    Online Resource
    CLCF1 signaling restrains thermogenesis and disrupts metabolic homeostasis by inhibiting mitochondrial biogenesis in brown adipocytes
    Proceedings of the National Academy of Sciences ; 2023
    In:  Proceedings of the National Academy of Sciences Vol. 120, No. 33 ( 2023-08-15)
    Details
    In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 120, No. 33 ( 2023-08-15)
    Abstract: Great progress has been made in identifying positive regulators that activate adipocyte thermogenesis, but negative regulatory signaling of thermogenesis remains poorly understood. Here, we found that cardiotrophin-like cytokine factor 1 (CLCF1) signaling led to loss of brown fat identity, which impaired thermogenic capacity. CLCF1 levels decreased during thermogenic stimulation but were considerably increased in obesity. Adipocyte-specific CLCF1 transgenic (CLCF1-ATG) mice showed impaired energy expenditure and severe cold intolerance. Elevated CLCF1 triggered whitening of brown adipose tissue by suppressing mitochondrial biogenesis. Mechanistically, CLCF1 bound and activated ciliary neurotrophic factor receptor (CNTFR) and augmented signal transducer and activator of transcription 3 (STAT3) signaling. STAT3 transcriptionally inhibited both peroxisome proliferator-activated receptor-γ coactivator (PGC) 1α and 1β, which thereafter restrained mitochondrial biogenesis in adipocytes. Inhibition of CNTFR or STAT3 could diminish the inhibitory effects of CLCF1 on mitochondrial biogenesis and thermogenesis. As a result, CLCF1-TG mice were predisposed to develop metabolic dysfunction even without external metabolic stress. Our findings revealed a brake signal on nonshivering thermogenesis and suggested that targeting this pathway could be used to restore brown fat activity and systemic metabolic homeostasis in obesity.
    Type of Medium: Online Resource
    ISSN: 0027-8424 , 1091-6490
    URL: Article
    DOI: 10.1073/pnas.2305717120
    RVK:
    TA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date: 2023
    detail.hit.zdb_id: 209104-5
    detail.hit.zdb_id: 1461794-8
    SSG: 11
    SSG: 12
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  • 3
    Online Resource
    Online Resource
    An evolutionarily conserved PTEN-C/EBPα-CTNNA1 axis controls myeloid development and transformation
    American Society of Hematology ; 2010
    In:  Blood Vol. 115, No. 23 ( 2010-06-10), p. 4715-4724
    Details
    In: Blood, American Society of Hematology, Vol. 115, No. 23 ( 2010-06-10), p. 4715-4724
    Abstract: Loss of function of tumor suppressor genes, such as PTEN, CEBPΑ, and CTNNA1 (encoding the α-catenin protein), has been found to play an essential role in leukemogenesis. However, whether these genes genetically interact remains largely unknown. Here, we show that PTEN-mammalian target of rapamycin signaling acts upstream to dictate the ratio of wild-type p42 C/EBPα to its dominant-negative p30 isoform, which critically determines whether p30 C/EBPα (lower p42/p30 ratio) or p42 C/EBPα (higher p42/p30 ratio) binds to the proximal promoter of the retained CTNNA1 allele. Binding of p30 C/EBPα recruits the polycomb repressive complex 2 to suppress CTNNA1 transcription through repressive H3K27me3 modification, whereas binding of p42 C/EBPα relieves this repression and promotes CTNNA1 expression through activating H3K4me3 modification. Loss of Pten function in mice and zebrafish induces myelodysplasia with abnormal invasiveness of myeloid progenitors accompanied by significant reductions in both wild-type C/EBPα and α-catenin protein. Importantly, frame-shift mutations in either PTEN or CEBPA were detected exclusively in the primary LICs with low CTNNA1 expression. This study uncovers a novel molecular pathway, PTEN-C/EBPα-CTNNA1, which is evolutionarily conserved and might be therapeutically targeted to eradicate LICs with low CTNNA1 expression.
    Type of Medium: Online Resource
    ISSN: 0006-4971 , 1528-0020
    URL: Article
    DOI: 10.1182/blood-2009-11-255778
    RVK:
    XA 33000
    RVK:
    XA 10000
    Language: English
    Publisher: American Society of Hematology
    Publication Date: 2010
    detail.hit.zdb_id: 1468538-3
    detail.hit.zdb_id: 80069-7
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  • 4
    Online Resource
    Online Resource
    Application of Multi-Objective Optimization Model in Design of Photovoltaic Architecture
    Trans Tech Publications, Ltd. ; 2013
    In:  Applied Mechanics and Materials Vol. 347-350 ( 2013-8), p. 1525-1529
    Details
    In: Applied Mechanics and Materials, Trans Tech Publications, Ltd., Vol. 347-350 ( 2013-8), p. 1525-1529
    Abstract: With the increasingly serious crisis of the energy problem, all around the world, the application of solar energy has become an approach of solving the problem undoubtedly. In recent years, due to the rapid development of Chinese photovoltaic (PV) industry, the emergence of PV buildings is more and more widely in the domestic. The current trend is to apply Computer-Aided Design (CAD) software to realize the design of Building Integrated Photovoltaic (BIPV). The core problem of CAD is to obtain the best solution to a laying scheme of PV cell. In this paper, the design problem of PV building is concerned about. Through the research on the multi-objective optimization theory, it is to establish the model of multi-objective optimization that can meet these two objectives of the largest total annual solar photovoltaic power generation, yet the smallest possible the unit cost of power generation. The model can be solved by MATLAB using ideal point method. In order to detail explain the application of model and verify it, the design of PV cabin, in Datong area of Shanxi Province, is as an example. The study has laid the foundation for the development of CAD in the future.
    Type of Medium: Online Resource
    ISSN: 1662-7482
    URL: Issue
    URL: Article
    DOI: 10.4028/www.scientific.net/AMM.347-350
    DOI: 10.4028/www.scientific.net/AMM.347-350.1525
    Language: Unknown
    Publisher: Trans Tech Publications, Ltd.
    Publication Date: 2013
    detail.hit.zdb_id: 2251882-4
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  • 5
    Online Resource
    Online Resource
    Rice NIN‐LIKE PROTEIN 4 plays a pivotal role in nitrogen use efficiency
    Wiley ; 2021
    In:  Plant Biotechnology Journal Vol. 19, No. 3 ( 2021-03), p. 448-461
    Details
    In: Plant Biotechnology Journal, Wiley, Vol. 19, No. 3 ( 2021-03), p. 448-461
    Abstract: Nitrogen (N) is one of the key essential macronutrients that affects rice growth and yield. Inorganic N fertilizers are excessively used to boost yield and generate serious collateral environmental pollution. Therefore, improving crop N use efficiency (NUE) is highly desirable and has been a major endeavour in crop improvement. However, only a few regulators have been identified that can be used to improve NUE in rice to date. Here we show that the rice NIN‐like protein 4 (OsNLP4) significantly improves the rice NUE and yield. Field trials consistently showed that loss‐of‐ OsNLP4 dramatically reduced yield and NUE compared with wild type under different N regimes. In contrast, the OsNLP4 overexpression lines remarkably increased yield by 30% and NUE by 47% under moderate N level compared with wild type. Transcriptomic analyses revealed that OsNLP4 orchestrates the expression of a majority of known N uptake, assimilation and signalling genes by directly binding to the nitrate‐responsive cis ‐element in their promoters to regulate their expression. Moreover, overexpression of OsNLP4 can recover the phenotype of Arabidopsis nlp7 mutant and enhance its biomass. Our results demonstrate that OsNLP4 plays a pivotal role in rice NUE and sheds light on crop NUE improvement.
    Type of Medium: Online Resource
    ISSN: 1467-7644 , 1467-7652
    URL: Issue
    URL: Article
    DOI: 10.1111/pbi.v19.3
    DOI: 10.1111/pbi.13475
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2136367-5
    SSG: 12
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  • 6
    Online Resource
    Online Resource
    Establishment of ultrasound-guided stellate ganglion block in rats
    Frontiers Media SA ; 2023
    In:  Frontiers in Neuroscience Vol. 16 ( 2023-1-12)
    Details
    In: Frontiers in Neuroscience, Frontiers Media SA, Vol. 16 ( 2023-1-12)
    Abstract: A novel protocol for accurate stellate ganglion block under ultrasound guidance was designed in rats. This technique raises the success rate of stellate ganglion block and reduces the incidence of brachial plexus and vagus nerve block. Methods Fifty-six Sprague-Dawley were randomly divided into an ultrasound-guided group ( n = 28) and a blind technique group ( n = 28). The rats in the blind technique group were injected with 1.5% lidocaine mixed with methylene blue after signs of brachial plexus stimulation were elicited. The lateral side of the cephalic brachial vein was located under the first rib, where lidocaine was injected into the rats in the ultrasound-guided group. The up-and-down sequential method of Dixon was used to determine the minimum effective volume for stellate ganglion block in rats. Furthermore, we calculated the required operative duration of the two methods and observed the difference in the lidocaine diffusion range between the two groups. Results The minimum effective volume for stellate ganglion block in the ultrasound-guided group was 0.040 ml, and the 95% CI was 0.026–0.052 ml. In the blind technique group, the minimum effective volume was 0.639 ml, and the 95% CI was 0.490–0.733 ml. Within the 95% CI of the lowest effective volume, the incidence of brachial plexus block as a complication of stellate ganglion block under ultrasound guidance was 10.00%. Conclusion Stellate ganglion block under ultrasound guidance is more accurate than blind detection, which the incidence of complications of stellate ganglion block under ultrasound guidance was significantly lower than under blind detection; the rate of methylene blue staining in the vagus nerve was significantly lower under ultrasound guidance.
    Type of Medium: Online Resource
    ISSN: 1662-453X
    URL: Article
    DOI: 10.3389/fnins.2022.1061767
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2411902-7
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  • 7
    Online Resource
    Online Resource
    Translocation, enzymatic reduction and toxicity of dimethylarsenate in rice
    Elsevier BV ; 2024
    In:  Plant Physiology and Biochemistry Vol. 207 ( 2024-02), p. 108393-
    Details
    In: Plant Physiology and Biochemistry, Elsevier BV, Vol. 207 ( 2024-02), p. 108393-
    Type of Medium: Online Resource
    ISSN: 0981-9428
    URL: Article
    DOI: 10.1016/j.plaphy.2024.108393
    RVK:
    WA 15000
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2024
    detail.hit.zdb_id: 2031431-0
    SSG: 12
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  • 8
    Online Resource
    Online Resource
    Adsorption of H2O by the Li decorated C6Li molecule
    Acta Physica Sinica, Chinese Physical Society and Institute of Physics, Chinese Academy of Sciences ; 2014
    In:  Acta Physica Sinica Vol. 63, No. 14 ( 2014), p. 147401-
    Details
    In: Acta Physica Sinica, Acta Physica Sinica, Chinese Physical Society and Institute of Physics, Chinese Academy of Sciences, Vol. 63, No. 14 ( 2014), p. 147401-
    Abstract: The generalized gradient approximation based on the density functional theory is used to study the adsorption process of H2O molecules by the Li decorated C6Li and the catalytic process of decomposition of H2O molecules. The geometry optimization shows that the most stable adsorption position of the Li is above the C atom of C6. Research shows that the adsorption of the first H2O molecule on C6Li needs to overcome an energy barrier of 1.77 eV, then H2O is decomposed into H and OH and bonding with Li atoms. Furthermore, the adsorption of the second H2O molecule needs to overcome an energy barrier of 1.2 eV and then the H2O molecule is decomposed into H and OH, the H atom in which and the H atom on the Li atom combine into an H2 molecule. OH replacing H atoms on Li atoms combines with the Li atom. Therefore, C6Li can be used as a catalyst for H2O molecules, and thus provide a new train of thought for the preparation of hydrogen storage material. The analysis shows that C6Li mainly adsorbs the H2O molecules through the dipole moment formed by the positive charge of Li and negative charge of H2O.
    Type of Medium: Online Resource
    ISSN: 1000-3290 , 1000-3290
    URL: Journal
    URL: Article
    DOI: 10.7498/aps
    DOI: 10.7498/aps.63.147401
    Language: Unknown
    Publisher: Acta Physica Sinica, Chinese Physical Society and Institute of Physics, Chinese Academy of Sciences
    Publication Date: 2014
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  • 9
    Online Resource
    Online Resource
    Table_1.docx
    Frontiers Media SA ; 2021
    In:  Frontiers in Medicine Vol. 8 ( 2021-12-22)
    Details
    In: Frontiers in Medicine, Frontiers Media SA, Vol. 8 ( 2021-12-22)
    Abstract: Background: Pneumocystis jirovecii is a human-specific opportunistic fungus that causes Pneumocystis pneumonia (PCP), a life-threatening opportunistic lung infection that affects immunocompromised patients. P. jirovecii colonization may be linked to the transmission of the infection. The detection of P. jirovecii in immunocompromised patients is thus especially important. The low fungal load and the presence of PCR inhibitors limit the usefulness of quantitative PCR (qPCR) for accurate absolute quantification of P. jirovecii in specimens. Droplet digital PCR (ddPCR), however, presents a methodology that allows higher sensitivity and accuracy. Here, we developed a ddPCR method for detecting P. jirovecii DNA in respiratory specimens, and evaluated its sensitivity against qPCR. Materials and Methods: One bronchoalveolar fluid (BALF) sample each was collected from 82 patients with potential PCP to test the presence of P. jirovecii DNA using both ddPCR and qPCR, and samples with inconsistent results between the two methods were further tested by metagenomic next generation sequencing (mNGS). In addition, 37 sputum samples from 16 patients diagnosed with PCP, as well as continuous respiratory tract specimens from nine patients with PCP and treated with sulfonamides, were also collected for P. jirovecii DNA testing using both ddPCR and qPCR. Results: ddPCR and qPCR gave the same results for 95.12% (78/82) of the BALF samples. The remaining four specimens tested positive using ddPCR but negative using qPCR, and they were found to be positive by mNGS. Detection results of 78.37% (29/37) sputum samples were consistent between ddPCR and qPCR, while the other eight samples tested positive using ddPCR but negative using qPCR. The P. jirovecii load of patients with PCP decreased to undetectable levels after treatment according to qPCR, but P. jirovecii was still detectable using ddPCR. Conclusions: ddPCR was more sensitive than qPCR, especially at detecting low-pathogen-load P. jirovecii . Thus, ddPCR represents a useful, viable, and reliable alternative to qPCR in P. jirovecii testing in patients with immunodeficiency.
    Type of Medium: Online Resource
    ISSN: 2296-858X
    URL: Article
    URL: Article
    DOI: 10.3389/fmed.2021.761788
    DOI: 10.3389/fmed.2021.761788.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2775999-4
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  • 10
    Online Resource
    Online Resource
    Non-pharmacological interventions for preventing suicide attempts: A systematic review and network meta-analysis
    Elsevier BV ; 2024
    In:  Asian Journal of Psychiatry Vol. 93 ( 2024-03), p. 103913-
    Details
    In: Asian Journal of Psychiatry, Elsevier BV, Vol. 93 ( 2024-03), p. 103913-
    Type of Medium: Online Resource
    ISSN: 1876-2018
    URL: Article
    DOI: 10.1016/j.ajp.2024.103913
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2024
    detail.hit.zdb_id: 2456678-0
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