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  • 1
    Online-Ressource
    Online-Ressource
    Missing the sweet spot: one of the two N-glycans on human Gb3/CD77 synthase is expendable
    Oxford University Press (OUP) ; 2021
    In:  Glycobiology ( 2021-05-08)
    Details
    In: Glycobiology, Oxford University Press (OUP), ( 2021-05-08)
    Kurzfassung: N-glycosylation is a ubiquitous posttranslational modification that may influence folding, subcellular localization, secretion, solubility and oligomerization of proteins. In this study, we examined the effects of N-glycans on the activity of human Gb3/CD77 synthase, which catalyzes the synthesis of glycosphingolipids with terminal Galα1→4Gal (Gb3 and the P1 antigen) and Galα1→4GalNAc disaccharides (the NOR antigen). The human Gb3/CD77 synthase contains two occupied N-glycosylation sites at positions N121 and N203. Intriguingly, we found that while the N-glycan at N203 is essential for activity and correct subcellular localization, the N-glycan at N121 is dispensable and its absence did not reduce, but, surprisingly, even increased the activity of the enzyme. The fully N-glycosylated human Gb3/CD77 synthase and its glycoform missing the N121 glycan correctly localized in the Golgi, whereas a glycoform without the N203 site partially mislocalized in the endoplasmic reticulum. A double mutein missing both N-glycans was inactive and accumulated in the endoplasmic reticulum. Our results suggest that the decreased specific activity of human Gb3/CD77 synthase glycovariants resulted from their improper subcellular localization and, to a smaller degree, a decrease in enzyme solubility. Taken together, our findings show that the two N-glycans of human Gb3/CD77 synthase have opposing effects on its properties, revealing a dual nature of N-glycosylation and potentially a novel regulatory mechanism controlling the biological activity of proteins.
    Materialart: Online-Ressource
    ISSN: 1460-2423
    URL: Article
    DOI: 10.1093/glycob/cwab041
    Sprache: Englisch
    Verlag: Oxford University Press (OUP)
    Publikationsdatum: 2021
    ZDB Id: 1478140-2
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    Online-Ressource
    Online-Ressource
    The influence of the ecohydrological rehabilitation in the cascade of Arturówek reservoirs in Łódź (Central Poland) on the cyanobacterial and algae blooming
    Uniwersytet Gdanski ; 2015
    In:  Oceanological and Hydrobiological Studies Vol. 44, No. 2 ( 2015-06-01), p. 236-244
    Details
    In: Oceanological and Hydrobiological Studies, Uniwersytet Gdanski, Vol. 44, No. 2 ( 2015-06-01), p. 236-244
    Kurzfassung: The objective of the studies included a complex of three reservoirs (upper, middle and lower Arturówek) which play an important recreational role for the residents of the Łódź city and the surrounding areas. The reservoirs were constructed on the Bzura River and are located in the area of the Łódź Hills Landscape Park. The river, the ecological status of which was defined as moderate, has a great influence on the quality of water in the Arturówek reservoirs. A total of 36 planktonic samples were collected in 2011-2013 during spring, summer and autumn seasons. During the studies, the selected physical and chemical parameters were measured. In addition to taxonomic analysis of Cyanobacteria and algae, the analyses of abundance and biomass of phytoplankton and the concentration of microcystins in water were conducted. In 2013, ecohydrological rehabilitation of the Arturówek reservoirs was carried out. Investment works included: removal of the bottom sediments to reduce internal loads, construction of buffer vegetation zones (ecotones) and sedimentation-biofiltration systems to reduce the amounts of pollutants flowing into reservoirs with rainwater. Significant changes in the structure of phytoplankton were observed in 2013. Every year, the disappearance of Cyanobacterial blooms was observed in favor of an increasing contribution of algae.
    Materialart: Online-Ressource
    ISSN: 1897-3191
    URL: Article
    DOI: 10.1515/ohs-2015-0022
    Sprache: Englisch
    Verlag: Uniwersytet Gdanski
    Publikationsdatum: 2015
    ZDB Id: 2128611-5
    ZDB Id: 2241495-2
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    Online-Ressource
  • 3
    Online-Ressource
    Online-Ressource
    The use of the Biological Diatom Index (BDI) for the assessment of water quality in the Pilica River, Poland
    Uniwersytet Gdanski ; 2013
    In:  Oceanological and Hydrobiological Studies Vol. 42, No. 2 ( 2013-06-01), p. 188-194
    Details
    In: Oceanological and Hydrobiological Studies, Uniwersytet Gdanski, Vol. 42, No. 2 ( 2013-06-01), p. 188-194
    Kurzfassung: The main aim of this study was to assess the usefulness of the Biological Diatom Index (BDI) (Lenoir & Coste 1996) for the estimation of water quality in the central section of the Pilica River, located in central Poland in Łódź province. The BDI has never been used before to monitor Polish surface waters. An analysis of the correlations between the values of the BDI and selected physico-chemical parameters was performed, as was an assessment of water quality using the BDI. On the basis of value ranges proposed by Descy and Ector (1996), a good ecological status in the Pilica River was obtained, but this did not correspond with the results achieved from the physico-chemical analysis. This study proposes new value ranges for the BDI. With these new values, the ecological state of the Pilica River changed from good to moderate, which corresponded with the physico-chemical analysis of the water. The new, proposed value ranges for the BDI assess more precisely the quality of water in lowland Polish rivers.
    Materialart: Online-Ressource
    ISSN: 1897-3191
    URL: Article
    DOI: 10.2478/s13545-013-0073-z
    Sprache: Englisch
    Verlag: Uniwersytet Gdanski
    Publikationsdatum: 2013
    ZDB Id: 2128611-5
    ZDB Id: 2241495-2
    Standort Signatur Einschränkungen Verfügbarkeit
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    Online-Ressource
  • 4
    Online-Ressource
    Online-Ressource
    Diatomological aspects of the Fenn’s and Whixall Mosses complex (Shropshire, UK)
    Uniwersytet Gdanski ; 2014
    In:  Oceanological and Hydrobiological Studies Vol. 43, No. 3 ( 2014-09-01), p. 274-282
    Details
    In: Oceanological and Hydrobiological Studies, Uniwersytet Gdanski, Vol. 43, No. 3 ( 2014-09-01), p. 274-282
    Kurzfassung: Peat bogs are unique and important habitats for biodiversity at the species and ecosystem level where low pH of water plays a major role. The main objective of the present study was to compare the benthic diatom assemblage structure of the selected part of the Fenn’s and Whixall Mosses complex in order to verify whether selected sampling sites differ from each other. The complex is a cut-over, lowland raised mire, which is a National Nature Reserve (NNR) and a Site of Special Scientific Interest (SSSI). Altogether 92 diatom species were identified in 72 benthic samples collected between September 2008 and August 2009 from six selected sampling sites. Statistical cluster analysis was used to classify diatom samples and to observe the structure of diatom assemblages. The results of this analysis grouped the data set into 3 clusters with 24 samples from each of the two sampling sites in one cluster. Such a clear division shows that pH of water has an impact on the species composition, the richness and diversity of benthic diatom assemblages.
    Materialart: Online-Ressource
    ISSN: 1897-3191
    URL: Article
    DOI: 10.2478/s13545-014-0142-y
    Sprache: Englisch
    Verlag: Uniwersytet Gdanski
    Publikationsdatum: 2014
    ZDB Id: 2128611-5
    ZDB Id: 2241495-2
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 5
    Online-Ressource
    Online-Ressource
    A reappraisal of K-Ar and new U-Pb age data for felsic rocks in the vicinity of the Kraków-Lubliniec Fault Zone (southern Poland)
    Polish Geological Institute - National Research Institute (PGI-NRI) ; 2020
    In:  Geological Quarterly Vol. 64, No. 3 ( 2020-9-7)
    Details
    In: Geological Quarterly, Polish Geological Institute - National Research Institute (PGI-NRI), Vol. 64, No. 3 ( 2020-9-7)
    Materialart: Online-Ressource
    ISSN: 1641-7291
    URL: Article
    DOI: 10.7306/gq.1549
    Sprache: Unbekannt
    Verlag: Polish Geological Institute - National Research Institute (PGI-NRI)
    Publikationsdatum: 2020
    ZDB Id: 2234076-2
    SSG: 13
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 6
    Online-Ressource
    Online-Ressource
    Diatom indices in the biological assessment of the water quality based on the example of a small lowland river
    Uniwersytet Gdanski ; 2014
    In:  Oceanological and Hydrobiological Studies Vol. 43, No. 3 ( 2014-09-01), p. 265-273
    Details
    In: Oceanological and Hydrobiological Studies, Uniwersytet Gdanski, Vol. 43, No. 3 ( 2014-09-01), p. 265-273
    Kurzfassung: The aim of the study was to compare the biological analyzes of the Linda River (Central Poland), which were based on three diatom indices: IO, GDI and IPS in order to select the best diatom index for the biological assessment of the lotic water quality. Additionally, the summary of the selected results of the biological and chemical analyzes was presented to show how precise the biological analyzes are as a basic tool in the assessment of the ecological status of the lotic waters. The results showed that each of the indices assessed the water in the Linda River to a specific but different quality class. The IO index showed class II of the water quality, while the IPS and GDI — class III. Statistical analysis conducted with the nonparametric Kruskal-Wallis test for independent samples (Kruskal, Wallis 1952) showed that differences in the values of individual indices at different sites were not statistically significant. It should be noticed that the IPS and GDI indices gave values that classify the water in the Linda River at least one class below. The obtained results confirmed that the biological methods are most reliable in the assessment of the water quality. These methods are less sensitive to a single impact of the environmental factors, therefore they permit accurate determination of the ecological status of the water ecosystems.
    Materialart: Online-Ressource
    ISSN: 1897-3191
    URL: Article
    DOI: 10.2478/s13545-014-0141-z
    Sprache: Englisch
    Verlag: Uniwersytet Gdanski
    Publikationsdatum: 2014
    ZDB Id: 2128611-5
    ZDB Id: 2241495-2
    Standort Signatur Einschränkungen Verfügbarkeit
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    Online-Ressource
  • 7
    Online-Ressource
    Online-Ressource
    Surirella barrowcliffia Donkin 1869 (Bacillariophyta, Surirellaceae): the first observation of the diatom in Poland
    Uniwersytet Gdanski ; 2017
    In:  Oceanological and Hydrobiological Studies Vol. 46, No. 4 ( 2017-12-20), p. 464-471
    Details
    In: Oceanological and Hydrobiological Studies, Uniwersytet Gdanski, Vol. 46, No. 4 ( 2017-12-20), p. 464-471
    Kurzfassung: Diatoms of the genus Surirella are considered to be a very diverse group, many of them are endemic species found in old lakes as well as in tropical regions worldwide. This study describes a new location of Surirella barrowcliffia . In 2005-2007, algological research on the taxonomic composition of benthic diatoms was conducted in the middle section of the Pilica River (Central Poland). A total of 23 benthic samples were collected from a single sampling site located in the town of Sulejów (159.8 km upriver). Altogether 242 diatom species were identified in the collected material. One of the most interesting taxa in this community was S. barrowcliffia . According to the information available in the world’s algological databases, such as Algaterra and AlgaeBase, S. barrowcliffia has so far been found only in England, France, Finland, northern Germany – in the Weser and the Kleine Wumme rivers, near Bremen, and in Romania in the Crapina-Jijila lake complex. S. barrowcliffia has not been recorded in the previous research conducted not only in the middle section of the Pilica River, but also in other Polish aquatic ecosystems.
    Materialart: Online-Ressource
    ISSN: 1897-3191
    URL: Article
    DOI: 10.1515/ohs-2017-0045
    Sprache: Englisch
    Verlag: Uniwersytet Gdanski
    Publikationsdatum: 2017
    ZDB Id: 2128611-5
    ZDB Id: 2241495-2
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 8
    Online-Ressource
    Online-Ressource
    Common pathomechanism of migraine and depression
    Komitet Redakcyjno - Wydawniczy Polskiego Towarzystwa Psychiatrycznego ; 2023
    In:  Psychiatria Polska Vol. 57, No. 2 ( 2023-4-30), p. 405-419
    Details
    In: Psychiatria Polska, Komitet Redakcyjno - Wydawniczy Polskiego Towarzystwa Psychiatrycznego, Vol. 57, No. 2 ( 2023-4-30), p. 405-419
    Kurzfassung: Migraine and depression often coexist and constitute an important clinical problem. Both disorders are associated with the necessity of chronic treatment, and their mutual coexistence contributes to the phenomenon of drug resistance. Influencing the functioning of patients, they also cause numerous social consequences – affecting the quality of life and achievement of personal goals of patients. This review presents factors that may explain the common pathomechanisms of depression and migraine. Structural and functional disturbances of the central nervous system (CNS), disturbances in the neurotransmitter systems, inflammatory theories, hormonal disturbances, as well as a possible genetic basis were taken into account. Due to the fact that both depression and migraine have a multifactorial etiology and at the present stage of scientific research it is difficult to clearly determine which factor is the most important, such a broad overview has been presented. It is also difficult to determine which of the above-mentioned factors, well documented in international studies, only coexist, and which of them may have a cause-and-effect relationship in the described disorders. Further research into the comorbidity and causes of migraine and depression seems to be worth considering.
    Materialart: Online-Ressource
    ISSN: 0033-2674 , 2391-5854
    Originaltitel: Wspólny patomechanizm migreny i depresji
    URL: Article
    DOI: 10.12740/PP/OnlineFirst/143982
    Sprache: Polnisch
    Verlag: Komitet Redakcyjno - Wydawniczy Polskiego Towarzystwa Psychiatrycznego
    Publikationsdatum: 2023
    ZDB Id: 2833968-X
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  • 9
    Online-Ressource
    Online-Ressource
    White Matter Integrity of the Corpus Callosum and Psychopathological Dimensions in Deficit and Non-Deficit Schizophrenia Patients
    MDPI AG ; 2021
    In:  Journal of Clinical Medicine Vol. 10, No. 11 ( 2021-05-21), p. 2225-
    Details
    In: Journal of Clinical Medicine, MDPI AG, Vol. 10, No. 11 ( 2021-05-21), p. 2225-
    Kurzfassung: Deficit syndrome (DS) is a subtype of schizophrenia characterized by primary persistent negative symptoms. The corpus callosum (CC) appears to be related to psychopathology in schizophrenia. This study assessed white matter integrity in the CC using diffusion tensor imaging (DTI) in deficit and non-deficit schizophrenia (NDS) patients. We also investigated the psychopathological dimensions of schizophrenia and their relationship to CC integrity. Fifteen DS patients, 40 NDS patients, and 30 healthy controls (HC) underwent psychiatric evaluation and neuroimaging. We divided the CC into five regions and assessed their fractional anisotropy (FA) and mean diffusivity (MD). Psychopathology was assessed with the Positive and Negative Syndrome Scale. DS patients had lower FA than NDS patients and HC, and higher MD in Region 5 of the CC than did HC. NDS patients had higher MD in Region 4 of the CC. The patient groups differed in terms of negative symptoms. After differentiating clinical groups and HC, no significant correlations were observed between DTI measures and psychopathological symptoms. Our results suggest that DS and NDS are characterized by minor impairments of the posterior CC. We confirmed that DS patients have greater negative psychopathology than NDS patients. Our results are preliminary, and further studies are needed.
    Materialart: Online-Ressource
    ISSN: 2077-0383
    URL: Article
    DOI: 10.3390/jcm10112225
    Sprache: Englisch
    Verlag: MDPI AG
    Publikationsdatum: 2021
    ZDB Id: 2662592-1
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  • 10
    Online-Ressource
    Online-Ressource
    The Pituitary Transcriptional Response Related to Feed Conversion in Pigs
    MDPI AG ; 2019
    In:  Genes Vol. 10, No. 9 ( 2019-09-14), p. 712-
    Details
    In: Genes, MDPI AG, Vol. 10, No. 9 ( 2019-09-14), p. 712-
    Kurzfassung: Over the decades, pig breeding objectives have focused on improving the meat content in the carcass without taking into consideration the more effective fattening indicators that affect feed conversion. At present, pig growth traits associated particularly with animal feeding have become crucial due to their economic significance. This is especially evident in countries where pigs are maintained on large farms. The present study indicates that pituitary differentially expressed genes (DEGs) are activated in response to variable feed conversion (FC) in pigs. The experiment included two native Polish breeds: Puławska and Złotnicka White (ZW). The whole pituitary transcriptome was sequenced using next-generation sequencing (NGS) technology. The RNA-seq method identified over 500 and 300 DEGs in the pituitaries of the ZW and the Puławska pig populations, respectively, that were associated with hormonal regulation, notch signaling, and Wnt pathways. Lower FC in the ZW pigs favoured increased fat content in the body and significantly higher prolactin expression. The obtained results indicate that low FC values in pigs are related to slower growth or increased fat content, which suggests various pituitary responses. Therefore, the identified candidate genes were not directly associated with feed conversion values but with other factors. However, the present study delivers new insights into pituitary regulation in pigs.
    Materialart: Online-Ressource
    ISSN: 2073-4425
    URL: Article
    DOI: 10.3390/genes10090712
    Sprache: Englisch
    Verlag: MDPI AG
    Publikationsdatum: 2019
    ZDB Id: 2527218-4
    Standort Signatur Einschränkungen Verfügbarkeit
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