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  • 1
    Online Resource
    Online Resource
    Circulating miRNA Profiling in Plasma Samples of Ovarian Cancer Patients
    MDPI AG ; 2019
    In:  International Journal of Molecular Sciences Vol. 20, No. 18 ( 2019-09-13), p. 4533-
    Details
    In: International Journal of Molecular Sciences, MDPI AG, Vol. 20, No. 18 ( 2019-09-13), p. 4533-
    Abstract: Ovarian cancer is one of the most common cancer types in women characterized by a high mortality rate due to lack of early diagnosis. Circulating miRNAs besides being important regulators of cancer development could be potential biomarkers to aid diagnosis. We performed the circulating miRNA expression analysis in plasma samples obtained from ovarian cancer patients stratified into FIGO I, FIGO III, and FIGO IV stages and from healthy females using the NanoString quantitative assay. Forty-five miRNAs were differentially expressed, out of these 17 miRNAs showed significantly different expression between controls and patients, 28 were expressed only in patients, among them 19 were expressed only in FIGO I patients. Differentially expressed miRNAs were ranked by the network-based analysis to assess their importance. Target genes of the differentially expressed miRNAs were identified then functional annotation of the target genes by the GO and KEGG-based enrichment analysis was carried out. A general and an ovary-specific protein–protein interaction network was constructed from target genes. Results of our network and the functional enrichment analysis suggest that besides HSP90AA1, MYC, SP1, BRCA1, RB1, CFTR, STAT3, E2F1, ERBB2, EZH2, and MET genes, additional genes which are enriched in cell cycle regulation, FOXO, TP53, PI-3AKT, AMPK, TGFβ, ERBB signaling pathways and in the regulation of gene expression, proliferation, cellular response to hypoxia, and negative regulation of the apoptotic process, the GO terms have central importance in ovarian cancer development. The aberrantly expressed miRNAs might be considered as potential biomarkers for the diagnosis of ovarian cancer after validation of these results in a larger cohort of ovarian cancer patients.
    Type of Medium: Online Resource
    ISSN: 1422-0067
    URL: Article
    DOI: 10.3390/ijms20184533
    Language: English
    Publisher: MDPI AG
    Publication Date: 2019
    detail.hit.zdb_id: 2019364-6
    SSG: 12
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  • 2
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    Estrogens regulate neuroinflammatory genes via estrogen receptors α and β in the frontal cortex of middle-aged female rats
    Springer Science and Business Media LLC ; 2011
    In:  Journal of Neuroinflammation Vol. 8, No. 1 ( 2011-12)
    Details
    In: Journal of Neuroinflammation, Springer Science and Business Media LLC, Vol. 8, No. 1 ( 2011-12)
    Abstract: Estrogens exert anti-inflammatory and neuroprotective effects in the brain mainly via estrogen receptors α (ERα) and β (ERβ). These receptors are members of the nuclear receptor superfamily of ligand-dependent transcription factors. This study was aimed at the elucidation of the effects of ERα and ERβ agonists on the expression of neuroinflammatory genes in the frontal cortex of aging female rats. Methods To identify estrogen-responsive immunity/inflammation genes, we treated middle-aged, ovariectomized rats with 17β-estradiol (E2), ERα agonist 16α-lactone-estradiol (16α-LE2) and ERβ agonist diarylpropionitrile (DPN), or vehicle by Alzet minipump delivery for 29 days. Then we compared the transcriptomes of the frontal cortex of estrogen-deprived versus ER agonist-treated animals using Affymetrix Rat230 2.0 expression arrays and TaqMan-based quantitative real-time PCR. Microarray and PCR data were evaluated by using Bioconductor packages and the RealTime StatMiner software, respectively. Results Microarray analysis revealed the transcriptional regulation of 21 immunity/inflammation genes by 16α-LE2. The subsequent comparative real-time PCR study analyzed the isotype specific effects of ER agonists on neuroinflammatory genes of primarily glial origin. E2 regulated the expression of sixteen genes, including down-regulation of complement C3 and C4b, Ccl2, Tgfb1, macrophage expressed gene Mpeg1, RT1-Aw2, Cx3cr1, Fcgr2b, Cd11b, Tlr4 and Tlr9, and up-regulation of defensin Np4 and RatNP-3b, IgG-2a, Il6 and ER gene Esr1. Similar to E2, both 16α-LE2 and DPN evoked up-regulation of defensins, IgG-2a and Il6, and down-regulation of C3 and its receptor Cd11b, Ccl2, RT1-Aw2 and Fcgr2b. Conclusions These findings provide evidence that E2, 16α-LE2 and DPN modulate the expression of neuroinflammatory genes in the frontal cortex of middle-aged female rats via both ERα and ERβ. We propose that ERβ is a promising target to suppress regulatory functions of glial cells in the E2-deprived female brain and in various neuroinflammatory diseases.
    Type of Medium: Online Resource
    ISSN: 1742-2094
    URL: Article
    DOI: 10.1186/1742-2094-8-82
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2011
    detail.hit.zdb_id: 2156455-3
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  • 3
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    Key indicators of organized cancer screening programs: Results from a Delphi study
    SAGE Publications ; 2019
    In:  Journal of Medical Screening Vol. 26, No. 3 ( 2019-09), p. 120-126
    Details
    In: Journal of Medical Screening, SAGE Publications, Vol. 26, No. 3 ( 2019-09), p. 120-126
    Abstract: To maximize benefits and reduce potential harms of organized cancer screening programs in Europe, monitoring, quality assurance, and evaluation of long-term impact are required. We aimed to identify the most important indicators to be collected and reported. The study was designed to establish a consensus within a European-level working group and suggest a manageable list of key indicators. Methods We conducted a Delphi study among policymakers, researchers, and program coordinators who were experts in breast, cervical, or colorectal cancer screening. Study participants evaluated the importance of screening indicators on a 5-point Likert scale. Results The top 10 indicators by study participants were interval cancer rate, detection rate, screening attendance, screening coverage, cancer incidence, cause-specific mortality, proportion of persons attending further assessment after a positive screen test result, proportion of persons attending a treatment after diagnosis, invitation coverage, and distribution of cancers by mode of detection. Performance indicators were generally considered more important than outcome indicators. Subgroup analyses by cancer types showed similar results, and only cervical cancer screening experts had slightly different preferences. Subgroup analyses by experts’ roles indicated that policymakers found different indicators important compared with researchers or program coordinators, probably because of their different point of view on screening. Conclusion The implication of our priority ranking is twofold: it serves as an initial guidance for countries that have not yet established a system to collect data, and as a checklist for those where data collection is already established, to assess the comprehensiveness of their system.
    Type of Medium: Online Resource
    ISSN: 0969-1413 , 1475-5793
    URL: Article
    DOI: 10.1177/0969141318820362
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2058901-3
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  • 4
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    Modeling costs and benefits of the organized colorectal cancer screening programme and its potential future improvements in Hungary
    SAGE Publications ; 2021
    In:  Journal of Medical Screening Vol. 28, No. 3 ( 2021-09), p. 268-276
    Details
    In: Journal of Medical Screening, SAGE Publications, Vol. 28, No. 3 ( 2021-09), p. 268-276
    Abstract: The national population-based colorectal cancer screening programme in Hungary was initiated in December 2018. We aimed to evaluate the current programme and investigate the costs and benefits of potential future changes to overcome the low coverage of the target population. Methods We performed an economic evaluation from a healthcare payer perspective using an established micro-simulation model (Microsimulation Screening Analysis-Colon). We simulated costs and benefits of screening with fecal immunochemical test in the Hungarian population aged 50–100, investigating also the impact of potential future scenarios which were assumed to increase invitation coverage: improvement of the IT platform currently used by GPs or distributing the tests through pharmacies instead of GPs. Results The model predicted that the current screening programme could lead to 6.2% colorectal cancer mortality reduction between 2018 and 2050 compared to no screening. Even higher reductions, up to 16.6%, were estimated when tests were distributed through pharmacies and higher coverage was assumed. This change in the programme was estimated to require up to 26 million performed fecal immunochemical tests and 1 million colonoscopies for the simulated period. These future scenarios have acceptable cost-benefit ratios of €8000–€8700 per life-years gained depending on the assumed adherence of invited individuals. Conclusions With its limitations, the current colorectal cancer screening programme in Hungary will have a modest impact on colorectal cancer mortality. Significant improvements in mortality reduction could be made at acceptable costs, if the tests were to be distributed by pharmacies allowing the entire target population to be invited.
    Type of Medium: Online Resource
    ISSN: 0969-1413 , 1475-5793
    URL: Article
    DOI: 10.1177/0969141320968598
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2058901-3
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  • 5
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    Online Resource
    Design and Study of Fractal-Inspired Metamaterials with Equal Density Made from a Strong and Tough Thermoplastic
    MDPI AG ; 2023
    In:  Polymers Vol. 15, No. 12 ( 2023-06-12), p. 2650-
    Details
    In: Polymers, MDPI AG, Vol. 15, No. 12 ( 2023-06-12), p. 2650-
    Abstract: In this study, we created metamaterials consisting of square unit cells—inspired by fractal geometry—and described the parametric equation necessary for their creation. The area and thus the volume (density) and mass of these metamaterials are constant regardless of the number of cells. They were created with two layout types; one consists solely of compressed rod elements (ordered layout), and in the other layout, due to a geometrical offset, certain regions are exposed to bending (offset layout). In addition to creating new metamaterial structures, our aim was to study their energy absorption and failure. Finite element analysis was performed on their expected behavior and deformation when subjected to compression. Specimens were printed from polyamide with additive technology in order to compare and validate the results of the FEM simulations with real compression tests. Based on these results, increasing the number of cells results in a more stable behavior and increased load-bearing capacity. Furthermore, by increasing the number of cells from 4 to 36, the energy absorption capability doubles; however, further increase does not significantly change this capability. As for the effect of layout, the offset structures are 27% softer, on average, but exhibit a more stable deformation behavior.
    Type of Medium: Online Resource
    ISSN: 2073-4360
    URL: Article
    DOI: 10.3390/polym15122650
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2527146-5
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  • 6
    Online Resource
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    The impact of delayed sample handling and type of anticoagulant on the interpretation of dysplastic signs detected by flow cytometry
    Croatian Society for Medical Biochemistry and Laboratory Medicine ; 2018
    In:  Biochemia Medica Vol. 28, No. 2 ( 2018-06-15)
    Details
    In: Biochemia Medica, Croatian Society for Medical Biochemistry and Laboratory Medicine, Vol. 28, No. 2 ( 2018-06-15)
    Type of Medium: Online Resource
    ISSN: 1330-0962 , 1846-7482
    URL: Article
    DOI: 10.11613/BM.2018.020704
    Language: English
    Publisher: Croatian Society for Medical Biochemistry and Laboratory Medicine
    Publication Date: 2018
    detail.hit.zdb_id: 2280328-2
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  • 7
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    Impact of fertilisation and the fluctuation of precipitation on the ecophysical and production characteristics of maize
    University of Debrecen/ Debreceni Egyetem ; 2014
    In:  Acta Agraria Debreceniensis , No. 61 ( 2014-09-18), p. 39-44
    Details
    In: Acta Agraria Debreceniensis, University of Debrecen/ Debreceni Egyetem, , No. 61 ( 2014-09-18), p. 39-44
    Abstract: The aim of this study was to analyse the problems caused by the unfavourable (dry and wet) weather and its consequences in the R1 growth stage of maize (Zeamays L.), as well as their management and the alternatives of preventing yield reduction by using agrotechnical measures fertilisation, irrigation), also, we wanted to examine whether the Chl content measured in the R1 growth phase provides reliable prediction of yield per hectare. The examinations were carried out in a moderately warm and dry production area at the Látókép Experiment Site of the University of Debrecen, Centre for Agricultural Sciences on calcareous chernozem soil in 2007 and 2008. Six different N doses (0,30,60,90,120,150 kg ha-1) were used in the irrigated and non-irrigated treatments of the field experiment. The results showed that there is a significant strong positive correlation between Chl content and yield both in the non-irrigated (P 〈 0.001, R=0.777) and the irrigated (P 〈 0.001, R=0.801) treatment. The results of the correlation analyses performed yearly showed that weather factors significantly influence the strength of correlations, but these correlations are always positive. The Chl content of maize leaves provided a reliable prediction of yield per hectare in the R1 growth stage. In the irrigated treatment, the correlation is always closer than in the non-irrigated treatment.
    Type of Medium: Online Resource
    ISSN: 2416-1640 , 1587-1282
    URL: Article
    DOI: 10.34101/actaagrar/61/2036
    Language: Unknown
    Publisher: University of Debrecen/ Debreceni Egyetem
    Publication Date: 2014
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  • 8
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    Impact of colorectal cancer screening on cancer-specific mortality in Europe: A systematic review
    Elsevier BV ; 2020
    In:  European Journal of Cancer Vol. 127 ( 2020-03), p. 224-235
    Details
    In: European Journal of Cancer, Elsevier BV, Vol. 127 ( 2020-03), p. 224-235
    Type of Medium: Online Resource
    ISSN: 0959-8049
    URL: Article
    DOI: 10.1016/j.ejca.2019.12.014
    RVK:
    XA 42017.A
    RVK:
    XA 42017
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2020
    detail.hit.zdb_id: 1120460-6
    detail.hit.zdb_id: 1468190-0
    detail.hit.zdb_id: 82061-1
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  • 9
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    Evaluation of the Nutrient Composition of Maize in Different NPK Fertilizer Levels Based on Multivariate Method Analysis
    Hindawi Limited ; 2021
    In:  International Journal of Agronomy Vol. 2021 ( 2021-4-1), p. 1-13
    Details
    In: International Journal of Agronomy, Hindawi Limited, Vol. 2021 ( 2021-4-1), p. 1-13
    Abstract: One of the critical issues in using micronutrient fertilisers is the comparison of methods and amounts of fertiliser use, which is very important from the aspect of increasing production and economic viewpoint. The aim of this research was to analyse the nutrient composition of different parts of the maize (Zea mays L. FAO 490) during the growing season with six-level nitrogen fertilisation supplies at five phenological stages. The study included essential nutrients as nitrogen (N), phosphorus (P), potassium (K), and sulphur (S) (in first cluster) and calcium (Ca) and magnesium (Mg) (in second cluster) in treatments on different leaf stage. Growth stages have different nutrient demands based on their actual demand. The first cluster included nitrogen and sulphur and the second included calcium and zinc in the NPK treatments on the stalk of plants. Nitrogen and potassium had their maximum effect on the stalk of maize during the growing season. Magnesium and copper were the second most important and desirable factors during the different growth stages and treatments in relation to the stalk. Nitrogen and calcium had their maximum impact during the yield formation stage and nitrogen and phosphorus had their most desirable effect during the grain filling stage. The effect of nitrogen on the quantitative and qualitative properties of maize showed that nitrogen increases the production of dry matter, grain yield, and its components. The maximum amount of absorption in the plants occurs before the accumulation of applied fertiliser, which is the prelude to the production of maximum biomass.
    Type of Medium: Online Resource
    ISSN: 1687-8167 , 1687-8159
    URL: Article
    DOI: 10.1155/2021/5537549
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2548961-6
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  • 10
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    A bibliographic review of climate change and fertilization as the main drivers of maize yield: implications for food security
    Springer Science and Business Media LLC ; 2023
    In:  Agriculture & Food Security Vol. 12, No. 1 ( 2023-06-02)
    Details
    In: Agriculture & Food Security, Springer Science and Business Media LLC, Vol. 12, No. 1 ( 2023-06-02)
    Abstract: Crop production contribution to food security faces unprecedented challenge of increasing human population. This is due to the decline in major cereal crop yields including maize resulting from climate change and declining soil infertility. Changes in soil nutrient status and climate have continued to occur and in response, new fertilizer recommendations in terms of formulations and application rates are continuously developed and applied globally. In this sense, this review was conducted to: (i) identify the key areas of concentration of research on fertilizer and climate change effect on maize grain yield, (ii) assess the extent of the effect of climate change on maize grain yield, (iii) evaluate the extent of the effect of fertilization practices on maize grain yield, and (iv) examine the effect of interaction between climate change factors and fertilization practices on maize grain yield at global perspective. Methodology Comprehensive search of global literature was conducted in Web of Science (WoS) database. For objective 1, metadata on co-authorship (country, organisation), and co-occurrence of keywords were exported and analysed using VOSviewer software. For objective 2–4, yield data for each treatment presented in the articles were extracted and yield increment calculated. Results The most significant keywords: soil fertility, nutrient use efficiency, nitrogen use efficiency, integrated nutrient management, sustainability, and climate change adaptation revealed efforts to improve maize production, achieve food security, and protect the environment. A temperature rise of 1–4 °C decreased yield by 5–14% in warm areas and increased by  〈  5% in cold areas globally. Precipitation reduction decreased yield by 25–32%, while CO 2 concentration increased and decreased yield by 2.4 to 7.3% and  9 to 14.6%, respectively. A promising fertilizer was a combination of urea + nitrapyrin with an average yield of 5.1 and 14.4 t ha −1 under non-irrigation and irrigation, respectively. Fertilization under climate change was projected to reduce yield in the average range of 10.5–18.3% by 2099. Conclusion The results signified that sole fertilizer intensification is insufficient to attain sustainable maize yield. Therefore, there is need for integrated agronomic research that combines fertilizers and other technologies for enhancing maize yield, and consequently maize contribution to the attainment of global food security under climate change conditions.
    Type of Medium: Online Resource
    ISSN: 2048-7010
    URL: Article
    DOI: 10.1186/s40066-023-00419-3
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2662504-0
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