In:
European Journal of Mass Spectrometry, SAGE Publications, Vol. 20, No. 2 ( 2014-04), p. 185-192
Abstract:
Characteristic ion mobility mass spectrometry data, reduced mobility, and limits of detection (signal-to-noise ratio = 3) were determined for six synthetic drugs and cocaine by ion mobility time-of-flight mass spectrometry (IM-TOF-MS) with electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI). The studied synthetic illicit drugs recently appeared on the recreational drug market as designer drugs and were methylone, 4-MEC (4′-methylethcathinone), 3,4-MDPV (3,4-methylenedioxypyrovalerone), JWH-210 [4-ethylnaphthalen-1-yl-(1-pentylindol-3-yl)methanone], JWH-250 [2-(2-methoxyphenyl)-1-(1-pentyl-1H-indol-3-yl)ethanone] , and JWH-203 [1-pentyl-3-(2′-chlorophenylacetyl) indole]. Absolute reduced mobilities in nitrogen were 1.35, 1.28, 1.41, 1.30, 1.18, 0.98, 1.09, and 1.07 cm 2 V −1 s −1 , for methylone [M–H] + , methylone [M+H] + , 4-MEC [M–H] + , 4-MEC [M+H] + , 3,4-MDPV [M+H] + , JWH-210 [M+H] + , JWH-250 [M+H] + , and JWH-203 [M+H] + , respectively. Selected illicit drugs are easily identified by IM-TOF-MS during a 100 s analysis. Relative limits of detection ranged from 4 to 400 nM are demonstrated for these compounds. Such relative limits of detection correspond to 14 pg to 2 ng absolute limits of detection. Better detection limits are obtained in APCI mode for all the illicit drugs except cocaine. ESI mode was found to be preferable for the IM-TOF-MS detection of cocaine at trace levels. A single sample analysis is completed in an order of magnitude less time than that for conventional liquid chromatography/mass spectrometry approach. The application allows one to consider IM-TOF-MS as a good candidate for a method to determine quickly the recently surfaced designer drugs marketed on the internet as “bath salts,” “spice,” and “herbal blends”.
Type of Medium:
Online Resource
ISSN:
1469-0667
,
1751-6838
Language:
English
Publisher:
SAGE Publications
Publication Date:
2014
detail.hit.zdb_id:
2021540-X
detail.hit.zdb_id:
2021340-2
SSG:
11
SSG:
12
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