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  • 1
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    Online Resource
    Prediction of cerebrovascular complications of coronary artery bypass grafting in patients without significant stenosis of the carotid arteries
    Medical Informational Agency Publishers ; 2022
    In:  Russian neurological journal Vol. 27, No. 2 ( 2022-05-14), p. 34-42
    Details
    In: Russian neurological journal, Medical Informational Agency Publishers, Vol. 27, No. 2 ( 2022-05-14), p. 34-42
    Abstract: Introduction. А pproximately 20% of all patients referred for coronary bypass surgery (CABG) have hemodynamically insignificant carotid artery stenoses. It is known that a decrease in the elasticity of the walls of the arteries of the brain due to atherosclerosis is a risk factor for cerebrovascular complications in cardiac surgery. The purpose of the work. Construction of prognostic models determining the probability of decompensation of chronic cerebral ischemia (CIG) and the development of early postoperative cognitive dysfunction (POCD) in patients with hemodynamically insignificant carotid artery stenosis in the hospital period of CABG performed under conditions of artificial circulation. Material and methods. 58 patients with 〈 50% carotid artery stenosis were examined, age – 56.2 [52.0; 63.0] years. Neurological, neuropsychological and laboratory-instrumental examinations were performed 2–3 days before and 8–9 days after the operation. The degree of narrowing of the carotid arteries was determined by color duplex scanning. Regression and ROC analyses were performed. Results. Decompensation of HIGM on day 8–9 of CABG was detected in 51.7%, early POCD – in 63.8% of patients. The prognostic criteria for the decompensation of the CIG and the development of early POCD were: a long history of arterial hypertension, low myocardial contractility, estimated by the preoperative index «left ventricular ejection fraction», a low average value of plasma glucose in the intraoperative period and the development of a systemic inflammatory reaction, estimated on the SOFA scale of «5 or more points» in 1–2 days after CABG. Conclusion. With the help of the obtained prognostic models, it is possible to stratify the probability of decompensation of HIGM and the development of early POCD in order to prescribe preventive treatment in a timely manner.
    Type of Medium: Online Resource
    ISSN: 2686-7192 , 2658-7947
    URL: Article
    DOI: 10.30629/2658-7947-2022-27-2-34-42
    Language: Unknown
    Publisher: Medical Informational Agency Publishers
    Publication Date: 2022
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  • 2
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    Effectiveness of dual-task computerized cognitive training in the prevention of postoperative cognitive dysfunction in coronary bypass surgery
    Silicea - Poligraf, LLC ; 2022
    In:  Cardiovascular Therapy and Prevention Vol. 21, No. 8 ( 2022-07-30), p. 3320-
    Details
    In: Cardiovascular Therapy and Prevention, Silicea - Poligraf, LLC, Vol. 21, No. 8 ( 2022-07-30), p. 3320-
    Abstract: Aim . To evaluate the effectiveness of dual-task computerized cognitive training (CCT) in the prevention of postoperative cognitive dysfunction in patients after on-pump coronary artery bypass grafting (CABG). Material and methods . This cohort prospective study included 68 patients (median age, 64 years [54; 69]) admitted for elective on-pump CABG. In addition to the standard preoperative examination, all patients underwent advanced neuropsychological and neurophysiological examination. Starting from 3-4 days of the postoperative period, all patients underwent dual-task CCT. Results . After 8-10 days, early postoperative cognitive dysfunction was observed in 37 (54,4%) patients from CCT group, while in patients without training in 69,3% of cases (n=79). The best results of cognitive functioning were achieved in neurodynamics and short-term memory. In addition, in patients who completed the training course, a postoperative increase in the frontooccipital gradient of theta rhythm was observed. Conclusion . Neuropsychological and neurophysiological assessment have demonstrated the limited effectiveness of a short-term dual task CCT using in the prevention of early postoperative cognitive dysfunction in patients after on-pump CABG. The dual task method can be an additional preventive intervention in the development of a personalized approach to cognitive rehabilitation therapy in cardiac surgery patients.
    Type of Medium: Online Resource
    ISSN: 2619-0125 , 1728-8800
    URL: Issue
    URL: Article
    DOI: 10.15829/1728-8800-2022-8
    DOI: 10.15829/1728-8800-2022-3320
    Language: Unknown
    Publisher: Silicea - Poligraf, LLC
    Publication Date: 2022
    detail.hit.zdb_id: 3032202-9
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  • 3
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    Neurophysiological status of patients with non-valve atrial fibrillation
    NII KPSSZ ; 2020
    In:  Complex Issues of Cardiovascular Diseases Vol. 8, No. 4S ( 2020-01-17), p. 22-31
    Details
    In: Complex Issues of Cardiovascular Diseases, NII KPSSZ, Vol. 8, No. 4S ( 2020-01-17), p. 22-31
    Abstract: Aim. To evaluate the neuropsychological parameters from the main cognitive domains (neurodynamic functions, attention and short-term memory) and the brain electrical activity in patients with non-valve atrial fibrillation (AF). Methods. 21 patients with the mean age of 61 [56; 67] years with non-valve AF who were admitted to the Department of Interventional Diagnosis and Treatment at the Research Institute for Complex Issues of Cardiovascular Disease were included in the study. The control group consisted of 17 healthy individuals with the mean age of 55 [49; 62] years. All patients underwent neuropsychological screening and computerized testing of neurodynamic functions, attention and short-term memory along with electroencephalographic studies. Statistical analysis was performed using the STATISTICA 10.0 software package. Results. Mild cognitive impairment was observed in 43% of patients with non-valve AF accompanied by ischemic brain matter changes according to the findings of magnetic resonance imaging. Patients with AF had slower complex sensorimotor reaction, more errors, worse directed attention, memorization of words and meaningless syllables in comparison with healthy individuals. In addition, patients with AF and healthy subjects had differences in the fronto-occipital gradient of theta-2 rhythm. The worst neurodynamic parameters were associated with a greater power of theta rhythms predominantly in the posterior parts of the brain only in patients with AF. Conclusion. Patients with non-valve AF had cognitive deficit with impaired executive control, attention and short-term memory as well as the slowing of cortical electrical activity in comparison to healthy individuals. The data obtained in our study are beneficial for developing an individual approach to prevent the development and progression of cognitive impairment in patients with AF.
    Type of Medium: Online Resource
    ISSN: 2587-9537 , 2306-1278
    URL: Issue
    URL: Article
    DOI: 10.17802/2306-1278-2019-8-4S
    DOI: 10.17802/2306-1278-2019-8-4S-22-31
    Language: Unknown
    Publisher: NII KPSSZ
    Publication Date: 2020
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  • 4
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    Neurophysiological Parameters in Patients after Coronary Bypass Grafting Depending on the Success of Dual-Task Rehabilitation
    Pleiades Publishing Ltd ; 2023
    In:  Human Physiology Vol. 49, No. 2 ( 2023-04), p. 107-114
    Details
    In: Human Physiology, Pleiades Publishing Ltd, Vol. 49, No. 2 ( 2023-04), p. 107-114
    Type of Medium: Online Resource
    ISSN: 0362-1197 , 1608-3164
    URL: Article
    DOI: 10.1134/S0362119722700165
    Language: English
    Publisher: Pleiades Publishing Ltd
    Publication Date: 2023
    detail.hit.zdb_id: 2057424-1
    SSG: 12
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  • 5
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    Online Resource
    Sex characteristics of cognitive functions assessed by the MMSE and MoCA scores in patients with coronary artery disease
    Silicea - Poligraf, LLC ; 2021
    In:  Russian Journal of Cardiology Vol. 26, No. 2 ( 2021-03-28), p. 4194-
    Details
    In: Russian Journal of Cardiology, Silicea - Poligraf, LLC, Vol. 26, No. 2 ( 2021-03-28), p. 4194-
    Abstract: Aim. To study the sex characteristics of cognitive functions in a cohort of patients undergoing coronary artery bypass grafting (CABG) by comparing the results of Mini-mental state examination (MMSE) and Montreal Cognitive Assessment (MoCA) scores. Material and methods. The prospective cohort study included 272 people, including 74 women aged 41 to 82 years, who were admitted to the Research Institute of Complex Issues of Cardiovascular Diseases for CABG surgery. All patients underwent clinical, laboratory, electrophysiological and ultrasound examinations. The Charlson comorbidity index (CCI) was calculated. Assessment of cognitive functions was carried out using the MMSE and MoCA scores. All types of statistical analysis were performed using the STATISTICA 10 program (StatSoft Inc., USA). Results. It was found that women scheduled for CABG have an older age and a higher CCI score compared to men (p=0,008). According to the MMSE, the likelihood of moderate and severe cognitive impairment in men compared with women was 1,36 times higher (odds ratio (OR), 1,35; 95% confidence interval (CI), 0,79-2,32, Z=1,11, p=0,27). The MoCA scores showed that half of the male (49%) and female (50%) participants had severe cognitive impairment. The likelihood of moderate and severe cognitive impairment in men compared with women was 1,33 times higher (OR, 1,33; 95% CI, 0,68-2,59, Z=0,841, p=0,40). According to subtests of the MoCA, men were better in naming (p=0,002), abstraction (p=0,005), and women outperformed men in verbal fluency (p=0,04). Regression analysis revealed that the most significant negative predictors for cognitive status as measured by the MMSE and MoCA scores for men and women were age and CCI. Conclusion. Women scheduled for CABG, having the worst clinical and demographic indicators, are comparable with men in cognitive status using the MMSE score. The MoCA score shows sex differences in naming, abstraction, and verbal fluency domains and revealed a higher percentage of severe cognitive disorders (up to 50%) compared to the MMSE score (7-9%). In male and female candidates for CABG, age and comorbidities are negatively associated with cognitive status.
    Type of Medium: Online Resource
    ISSN: 2618-7620 , 1560-4071
    URL: Issue
    URL: Article
    DOI: 10.15829/1560-4071-2021-2
    DOI: 10.15829/1560-4071-2021-4194
    Language: Unknown
    Publisher: Silicea - Poligraf, LLC
    Publication Date: 2021
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  • 6
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    Impact of short-term physical prehabilitation on psychophysiological parameters in patients undergoing coronary artery bypass grafting
    Kemerovo State Medical University ; 2020
    In:  Fundamental and Clinical Medicine Vol. 5, No. 4 ( 2020-12-25), p. 65-75
    Details
    In: Fundamental and Clinical Medicine, Kemerovo State Medical University, Vol. 5, No. 4 ( 2020-12-25), p. 65-75
    Abstract: Aim. To study psychophysiological parameters in the patients undergoing coronary artery bypass grafting (CABG) who optionally underwent a short course of physical prehabilitation (PPR). Materials and Methods. We carried out a prospective randomised study which included 97 male patients (45 to 70 years) with coronary artery disease who underwent elected CABG; 47 of them additionally underwent a 5-7-day course of aerobic physical training before the surgery. Both patient groups were comparable with respect to the baseline clinicopathological features. Neuropsychological examination and electroencephalography was performed before the surgery and at 7th-10th day after CABG. Development of postoperative cognitive dysfunction (POCD) was considered as the study endpoint. Results. POCD developed in 58% patients with PPR and in 78.7% patients without PPR (p = 0.037); therefore, the risk of developing POCD in those who underwent PPR was lower (OR=0,39, р=0,045). Further, patients with PPR showed an increase in integral attention value relative to the preoperative state (p = 0.04) while those without PPR demonstrated a decrease in this cognitive parameter (p = 0.03). Integral attention value and general cognitive status remained higher in patients with PPR than in those without (p = 0.048 and p = 0.048, respectively) at 7th-10th day after CABG. The theta1 rhythm power increase was higher in patients without PPR at 7th-10th day after CABG (p = 0.01). Conclusion. The patients with a short preoperative course of PPR had better indicators of electrical cortical activity and higher integral cognitive value in the early postoperative period after CABG than those without training. Short course of PPR before CABG can increase the resistance of the brain to the intraoperative injury and may reduce the severity of the cognitive impairment after cardiac surgery. Indicators of brain electrical activity can be informative to evaluate the efficiency of cardiac rehabilitation
    Type of Medium: Online Resource
    ISSN: 2542-0941 , 2500-0764
    URL: Article
    DOI: 10.23946/2500-0764-2020-5-4-65-75
    Language: Unknown
    Publisher: Kemerovo State Medical University
    Publication Date: 2020
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  • 7
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    Impact of preoperative mild cognitive impairment on cerebrovascular events and cognitive status in patients undergoing coronary artery bypass grafting: data from 5-year follow-up
    Silicea - Poligraf, LLC ; 2021
    In:  Russian Journal of Cardiology Vol. 26, No. 9 ( 2021-10-19), p. 4519-
    Details
    In: Russian Journal of Cardiology, Silicea - Poligraf, LLC, Vol. 26, No. 9 ( 2021-10-19), p. 4519-
    Abstract: Aim . To assess the incidence of cerebrovascular events and cognitive status in the long-term period after coronary artery bypass grafting (CABG) in patients with and without preoperative mild cognitive impairment (MCI). Material and methods . This prospective study involved 115 patients aged 45 to 69 years, who were admitted to the hospital for elective on-pump CABG. All patients underwent clinical, laboratory, ultrasound, neuroimaging and neuropsychological examination 3-5 days before and 5-7 years after CABG. Cognitive functioning was assessed using screening neuropsychological scales and neuropsychological testing with an assessment of neurodynamics, attention and short-term memory. Pre-CABG MCI was diagnosed based on the criteria by R. Petersen et al. Therefore, the patients were divided into two groups: with (n=51) and without MCI (n=64). Results . It was found that strokes and dementia during the long-term postoperative period of CABG were observed only in the group of patients with preoperative MCI (7,84%). Five-seven years after CABG, a decrease in cognitive status according to neuropsychological scales was found in all patients (p≤0,05). A decrease in neurodynamics, attention and short-term memory compared to the preoperative level was found in 47,92% of patients with preoperative MCI, without MCI — in 40,63%. Neurodynamic disorders occurred equally frequently in both groups (63,8% and 57,8% of patients, respectively). Memory impairments were more often observed in patients with MCI (55,3%) compared to those without MCI (34,4%) (OR=2,36, 95% CI, 1,09-5,12, p=0,03). According to brain multislice computed tomography in the group with preoperative MCI, the number of patients with cysts and leukoaraiosis 5-7 years after CABG was higher than in those without MCI (p≤0,05). Conclusion . In the long-term (5-7 years) postoperative period of CABG, more than 40% of patients demonstrate a decrease in cognitive status, regardless of preoperative data. At the same time, preoperative MCI is associated with adverse cerebrovascular events and dementia, accompanied by morphological brain abnormalities. Due to the revealed facts, it is necessary to optimize approaches to drug treatment and secondary prevention of cognitive decline after cardiac surgery.
    Type of Medium: Online Resource
    ISSN: 2618-7620 , 1560-4071
    URL: Issue
    URL: Article
    DOI: 10.15829/1560-4071-2021-9
    DOI: 10.15829/1560-4071-2021-4519
    Language: Unknown
    Publisher: Silicea - Poligraf, LLC
    Publication Date: 2021
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  • 8
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    Online Resource
    Age as a Risk Factor for Cognitive Impairments in Patients Undergoing Coronary Bypass
    Springer Science and Business Media LLC ; 2013
    In:  Neuroscience and Behavioral Physiology Vol. 43, No. 1 ( 2013-1), p. 89-92
    Details
    In: Neuroscience and Behavioral Physiology, Springer Science and Business Media LLC, Vol. 43, No. 1 ( 2013-1), p. 89-92
    Type of Medium: Online Resource
    ISSN: 0097-0549 , 1573-899X
    URL: Article
    DOI: 10.1007/s11055-012-9696-6
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2013
    detail.hit.zdb_id: 2037678-9
    SSG: 12
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  • 9
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    Mild cognitive impairment in patients with coronary artery disease: clinical-demographyc and EEG-correlates
    Media Sphere Publishing Group ; 2014
    In:  Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova Vol. 114, No. 12 ( 2014), p. 89-
    Details
    In: Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, Media Sphere Publishing Group, Vol. 114, No. 12 ( 2014), p. 89-
    Type of Medium: Online Resource
    ISSN: 1997-7298
    URL: Article
    DOI: 10.17116/jnevro201411412189-93
    Language: English
    Publisher: Media Sphere Publishing Group
    Publication Date: 2014
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  • 10
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    Indicators of cognitive functions in patients after coronary artery bypass grafting (five-year follow-up).
    Medical Informational Agency Publishers ; 2018
    In:  Clinical Medicine (Russian Journal) Vol. 96, No. 7 ( 2018-12-15), p. 612-619
    Details
    In: Clinical Medicine (Russian Journal), Medical Informational Agency Publishers, Vol. 96, No. 7 ( 2018-12-15), p. 612-619
    Abstract: Purpose. We aimed to evaluate the long-term results of cognitive functions in patients in 1 year and 5 years after coronary artery bypass grafting (CABG). Material and methods. We examined 98 men aged 45-69years. Cognitive functions were evaluated prior to CABG, 1 year and 5 years after CABG. Discussion. The evaluation of neuropsychological status allowed to diagnose a cognitive decline and to compare the dynamics at different stages of the study: baseline 1 year and 5 years later in patients after CABG. Various dynamics in the basic cognitive domains (upon the indicators of memory, attention and neurodynamics) was revealed in the long-term postoperative period. The positive dynamics in the tests for attention and memory in the annual stage is probably provided by the “learning effect ” and relative “simplicity ” of the tasks execution. The regression of memory and attention indicators by the fifth year of the study till the baseline preoperative level was probably the result of the combination offactors: a natural age decline in cognitive functions, a large gap between the studies (4 years) and of course a long-term CABG effect. The studied sample of the patients was interested in convalescence, highly motivated and compliant to medical recommendations at all the stages of postoperative period. Results. Multidirectional dynamics in cognitive indicators was noted at annual and five-year stages offollow-up in patients underwent CABG. By the first year after CABG there was a significant tendency towards the improvement of cognitive functions in memory, attention and neurodynamics indicators. At the five-years follow-up stage there was a regression in memory, attention and neurodynamics indicators towards the baseline preoperative level. Conclusions. The active curation of patients after CABG by a multidisciplinary team will allow to timely reveal a cognitive
    Type of Medium: Online Resource
    ISSN: 2412-1339 , 0023-2149
    URL: Issue
    URL: Article
    DOI: 10.18821/0023-2149-2018-96-7
    DOI: 10.18821/0023-2149-2018-96-7-612-619
    Language: Unknown
    Publisher: Medical Informational Agency Publishers
    Publication Date: 2018
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