In:
Journal of the chemical society of pakistan, Chemical Society of Pakistan, Vol. 41, No. 1 ( 2019), p. 113-113
Abstract:
This study focuses characterization of iron (II), iron (III), cobalt (II), copper (II) and nickel (II) complexes of Isoniazid (INH) and studying their spectroscopic as well as physiochemical properties. FTIR studies showed that INH binds the metal from oxygen of carbonyl group and nitrogen of amino group. The proton NMR spectra of the metal complexes confirmed the conversion of ligand molecules into their respective metal complexes. However, pattern of splitting and shapes of peaks was observed but the protons resonated in the expected region. XRD patterns may be concluded that the complexes are mostly comprised of nano-sized particles behaving like amorphous materials. Scanning electron microscopy (SEM) revealed marked changes in the morphology of complexes, and their degradation at higher temperature strengthens the hypothesis of the successful formation of complexes. The MTT cytotoxicity assay was used for the screening these complexes against four human cell lines but the results did not prove significant.
Type of Medium:
Online Resource
ISSN:
0253-5106
Uniform Title:
Synthesis, Characterization and Anticancer Activity of Isonicotinylhydrazide Metal Complexes
DOI:
10.52568/000706/JCSP/41.01.2019
Language:
Unknown
Publisher:
Chemical Society of Pakistan
Publication Date:
2019
detail.hit.zdb_id:
3024078-5
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