In:
Journal of Pharmaceutical Health Care and Sciences, Springer Science and Business Media LLC, Vol. 8, No. 1 ( 2022-11-01)
Abstract:
It is possible that increased synthesis of metallothioneins (MTs), Zn 2+ -binding proteins is linked with the protective effect of Ninjin-yoei-to (NYT) on Zn 2+ toxicity ferried by amyloid β 1-42 (Aβ 1-42 ). Methods Judging from the biological half-life (18-20 h) of MTs,
the effective period of newly synthesized MT on capturing Zn 2+ is
estimated to be approximately 2 days. In the present paper, a diet containing 3% NYT was administered to mice for 2 days and then Aβ 1-42 was injected
into the lateral ventricle of mice. Results MT level in the dentate granule cell layer was elevated 2 days after administration of NYT diet, while the administration reduced intracellular Zn 2+ level increased 1 h after Aβ 1-42 injection, resulting in rescuing neuronal death in the dentate granule cell layer, which was observed 14 days after Aβ 1-42 injection. Furthermore, Pre-administration of NYT diet rescued object recognition memory loss via affected perforant pathway long-term potentiation after local injection of Aβ 1-42 into the dentate granule cell layer of rats. Conclusion The present study indicates that pre-administration of NYT diet for 2 days increases synthesis of MTs, which reduces intracellular Zn 2+ toxicity ferried by extracellular Aβ 1-42 , resulting in protecting neuronal death in the dentate gyrus and memory loss after exposure to Aβ 1-42 .
Type of Medium:
Online Resource
ISSN:
2055-0294
DOI:
10.1186/s40780-022-00257-8
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2022
detail.hit.zdb_id:
2809913-8
SSG:
15,3
Permalink