In:
The Journal of Immunology, The American Association of Immunologists, Vol. 192, No. 1_Supplement ( 2014-05-01), p. 73.11-73.11
Abstract:
Polyfunctionality is a hallmark of protective immunity against pathogens and cancer. However, the molecular mechanisms governing the induction of polyfunctional T cells are not completely understood. We found that during antigen-driven expansion of human virus-specific T cells, Wnt pathway activation enhances the CD62L+, CD28+, and KLRG1- central memory T cell phenotype and promoted the generation of highly polyfunctional virus-specific T cells. Such effects are not only seen in influenza-specific responses but also in terminally differentiated CMV- and HIV-specific T cells. Mechanistically induction of polyfunctionality was independent of arresting antigen-specific cell expansion and is T cell-intrinsic. These findings provide the first evidence that Wnt pathway activation leads to polyfunctional antigen-specific memory human T cells responses and therefore have implications for treatment of chronic viral infections and cancer.
Type of Medium:
Online Resource
ISSN:
0022-1767
,
1550-6606
DOI:
10.4049/jimmunol.192.Supp.73.11
Language:
English
Publisher:
The American Association of Immunologists
Publication Date:
2014
detail.hit.zdb_id:
1475085-5
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