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  • 1
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    Online Resource
    Alcohol Consumption and Functional Limitations in Older Men: Does Muscle Strength Mediate Them?
    Wiley ; 2019
    In:  Journal of the American Geriatrics Society Vol. 67, No. 11 ( 2019-11), p. 2331-2337
    Details
    In: Journal of the American Geriatrics Society, Wiley, Vol. 67, No. 11 ( 2019-11), p. 2331-2337
    Abstract: To evaluate the dose‐response relationships between alcohol consumption and functional limitations in older European men, and explore the role of muscle strength as a mediator of these relationships. DESIGN Cross‐sectional study of older men participating in the Survey of Health, Aging and Retirement in Europe (SHARE). SETTING Urban and rural households in 17 European countries and Israel. PARTICIPANTS A total of 17 870 men aged 65 years and older from the SHARE (Wave 6, 2015) were included in this study. MEASUREMENTS Outcome variables were functional limitations: mobility limitation, arm function limitation, and fine motor limitation. Main exposure variable was alcohol consumption. Mediating factor was grip strength. Basic demographics, life habits, and health status were considered as potential confounders. Dose‐response analyses with restricted cubic splines and the Karlson/Holm/Breen method were conducted. RESULTS A total of 17 870 participants were included in this study. Dose‐response analyses revealed that moderate alcohol consumption was related to the lower odds of reporting mobility limitation (≤35 units/wk) and arm function limitation (≤41 units/wk), with a minimum odds ratio (OR) occurring at 10 units/week drinks for mobility limitation (OR = .71; 95% confidence interval [CI] = .62‐.81) and arm function limitation (OR = .66; 95% CI = .59‐.75). The odds of reporting the fine motor limitation monotonically increased with alcohol consumption when alcohol consumption was beyond 15 units/week. No significant mediating effect of grip strength on the relationships between alcohol consumption and mobility limitation and arm function limitation was found. CONCLUSION Moderate alcohol consumption has a protective role in mobility and arm function limitation in older European men. Grip strength is not the main mediator of these associations, suggesting that the protective effect is independent of muscle strength. Alcohol consumption is associated with higher odds of reporting fine motor limitation in older European men. J Am Geriatr Soc 67:2331–2337, 2019
    Type of Medium: Online Resource
    ISSN: 0002-8614 , 1532-5415
    URL: Issue
    URL: Article
    DOI: 10.1111/jgs.v67.11
    DOI: 10.1111/jgs.16082
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2040494-3
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  • 2
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    Proteomic Analysis of Plasma in Adult Active Pulmonary Tuberculosis Patients with Diabetes Mellitus
    Clinical Laboratory Publications ; 2015
    In:  Clinical Laboratory Vol. 61, No. 10/2015 ( 2015)
    Details
    In: Clinical Laboratory, Clinical Laboratory Publications, Vol. 61, No. 10/2015 ( 2015)
    Type of Medium: Online Resource
    ISSN: 1433-6510
    URL: Article
    DOI: 10.7754/Clin.Lab.2015.150210
    Language: English
    Publisher: Clinical Laboratory Publications
    Publication Date: 2015
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  • 3
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    Proteomic analysis of plasma in adult active pulmonary tuberculosis patients with diabetes mellitus
    Wiley ; 2015
    In:  The FASEB Journal Vol. 29, No. S1 ( 2015-04)
    Details
    In: The FASEB Journal, Wiley, Vol. 29, No. S1 ( 2015-04)
    Type of Medium: Online Resource
    ISSN: 0892-6638 , 1530-6860
    URL: Issue
    URL: Article
    DOI: 10.1096/fsb2.v29.S1
    DOI: 10.1096/fasebj.29.1_supplement.275.7
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 1468876-1
    SSG: 12
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  • 4
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    Association between retinol intake and hyperuricaemia in adults
    Cambridge University Press (CUP) ; 2021
    In:  Public Health Nutrition Vol. 24, No. 8 ( 2021-06), p. 2205-2214
    Details
    In: Public Health Nutrition, Cambridge University Press (CUP), Vol. 24, No. 8 ( 2021-06), p. 2205-2214
    Abstract: Current evidences on the association between hyperuricaemia and retinol intake remain inconsistent. Furthermore, no known studies have investigated the relationship between hyperuricaemia and retinol intake from animal food and plant food separately. This study aimed to assess the relationship between different sources of retinol intake and risk of hyperuricaemia among US adults. Design: Univariate and multivariate weighted logistic regression models and restricted cubic spline models were used to assess the associations of total, animal-derived and plant-derived retinol intakes with the risk of hyperuricaemia. Dietary retinol was measured through two 24-h dietary recall interviews. Hyperuricaemia was defined as serum uric acid level ≥7·0 and ≥6·0 mg/dl in men and women, respectively. Setting: Data from the National Health and Nutrition Examination Survey 2009–2014 were used in this cross-sectional study. Participants: Overall, 12 869 participants aged ≥20 years were included. Results: Compared with the lowest quintile, the multivariable OR of hyperuricaemia for the highest quintile intake of total, animal-derived and plant-derived retinol were 0·71 (95 % CI 0·52, 0·96), 0·76 (95 % CI 0·59, 0·96) and 0·92 (95 % CI 0·72, 1·17), respectively. The inverse association between dietary intake of total retinol and the risk of hyperuricaemia was observed in men. Dose–response analyses revealed a novel linear trend between the risk of hyperuricaemia and total, animal-derived retinol intake separately. Conclusions: Our findings indicated that intakes of total and animal-derived retinol were negatively associated with hyperuricaemia in US adults.
    Type of Medium: Online Resource
    ISSN: 1368-9800 , 1475-2727
    URL: Article
    DOI: 10.1017/S1368980020000324
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2021
    detail.hit.zdb_id: 2016337-X
    SSG: 21
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  • 5
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    Propylenedioxy Thiophene Donor to Achieve NIR-II Molecular Fluorophores with Enhanced Brightness
    American Chemical Society (ACS) ; 2020
    In:  Chemistry of Materials Vol. 32, No. 5 ( 2020-03-10), p. 2061-2069
    Details
    In: Chemistry of Materials, American Chemical Society (ACS), Vol. 32, No. 5 ( 2020-03-10), p. 2061-2069
    Type of Medium: Online Resource
    ISSN: 0897-4756 , 1520-5002
    URL: Article
    URL: Article
    DOI: 10.1021/acs.chemmater.9b05159
    DOI: 10.1021/acs.chemmater.9b05159.s001
    Language: English
    Publisher: American Chemical Society (ACS)
    Publication Date: 2020
    detail.hit.zdb_id: 1500399-1
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  • 6
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    Hydraulic Characteristics and Vortex Characteristics of the Flow around the Piped Vehicle with Different Diameter-to-Length Ratios
    MDPI AG ; 2022
    In:  Water Vol. 15, No. 1 ( 2022-12-29), p. 126-
    Details
    In: Water, MDPI AG, Vol. 15, No. 1 ( 2022-12-29), p. 126-
    Abstract: Hydraulic pipeline transportation of a piped vehicle is a new mode of transportation with energy-saving potential and environmental protection. In order to analyze the turbulent characteristics of the flow around the piped vehicle, a large eddy simulation (LES) method was adopted to simulate the hydraulic characteristics and vortex characteristics of the flow at a Reynolds number of Re = 140,467 with diameter-to-length ratios of 0.4, 0.5, 0.6, and 0.7. The results showed that the main factor that affected the gap flow velocity, the backflow area length, and the turbulence intensity was the cylinder diameter in the diameter-to-length ratio of the piped vehicle. The backflow area lengths for piped vehicles with different diameter-to-length ratios were all less than 1 D, and the axial disturbance distances were about 7.5 D. In addition, a variety of vortex structures existed in the gap flow and the rear flow areas. At the beginning of vortex development, ring vortices were generated at the front and rear ends of the cylinder body. Subsequently, the front ring vortex fell off along the cylinder body and evolved into hairpin vortices. At the same time, a reflux vortex was formed after the rear ring vortex broke away from the cylinder body, and wake vortices were generated behind the rear supports. Finally, some worm vortices were dispersed from the wake vortices. These results can further improve the theoretical system for the hydraulic pipeline transportation of piped vehicles and can provide a theoretical basis for industrial application.
    Type of Medium: Online Resource
    ISSN: 2073-4441
    URL: Article
    DOI: 10.3390/w15010126
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2521238-2
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  • 7
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    Sodium Alginate Prevents Non-Alcoholic Fatty Liver Disease by Modulating the Gut–Liver Axis in High-Fat Diet-Fed Rats
    MDPI AG ; 2022
    In:  Nutrients Vol. 14, No. 22 ( 2022-11-16), p. 4846-
    Details
    In: Nutrients, MDPI AG, Vol. 14, No. 22 ( 2022-11-16), p. 4846-
    Abstract: Previous studies have suggested that the sodium alginate (SA) is beneficial for the treatment of non-alcoholic fatty liver disease (NAFLD), while the potential mechanisms are largely unknown. The present study aimed to clarify the effects and potential mechanisms of SA in preventing NAFLD via the gut−liver axis. Thirty-two male Sprague−Dawley rats were randomly divided into four groups: normal control group (NC); high-fat diet group (HFD); HFD with 50 mg/kg/d sodium alginate group (LSA); HFD with 150 mg/kg/d sodium alginate group (HSA). After 16 weeks, the rats were scarified to collect blood and tissues. The results indicated that SA significantly reduced their body weight, hepatic steatosis, serum triglyceride (TG), alanine transaminase (ALT) and tumor necrosis factor α (TNF-α) levels and increased serum high-density lipoprotein-cholesterol (HDL-C) levels in comparison with HFD group (p 〈 0.05). The elevated mRNA and protein expression of genes related to the toll-like receptor 4 (TLR-4)/nuclear factor-kappa B (NF-κB)/nod-like receptor protein 3 (NLRP3) inflammatory signaling pathway in the liver of HFD-fed rats was notably suppressed by SA. In terms of the gut microbiota, the LSA group showed a significantly higher fecal abundance of Oscillospiraceae_UCG_005, Butyricicoccaceae_UCG_009 and Colidextribacter compared with the HFD group (p 〈 0.05). The rats in the HSA group had a higher abundance of unclassified_Lachnospiraceae, Colidextribacter and Oscillibacter compared with the HFD-associated gut community (p 〈 0.05). In addition, rats treated with SA showed a significant increase in fecal short chain fatty acids (SCFAs) levels and a decline in serum lipopolysaccharide (LPS) levels compared with the HFD group (p 〈 0.05). Moreover, the modulated bacteria and microbial metabolites were notably correlated with the amelioration of NAFLD-related indices and activation of the hepatic TLR4/NF-κB/NLRP3 pathway. In conclusion, SA prevented NAFLD and the potential mechanism was related to the modulation of the gut–liver axis.
    Type of Medium: Online Resource
    ISSN: 2072-6643
    URL: Article
    DOI: 10.3390/nu14224846
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2518386-2
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  • 8
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    Origins of near-infrared-II emission tail and fluorescence enhancement of albumin-chaperoned cyanine dyes from a multiscale computational study
    Royal Society of Chemistry (RSC) ; 2023
    In:  Journal of Materials Chemistry C Vol. 11, No. 22 ( 2023), p. 7243-7251
    Details
    In: Journal of Materials Chemistry C, Royal Society of Chemistry (RSC), Vol. 11, No. 22 ( 2023), p. 7243-7251
    Abstract: Repurposing the commercially available NIR-I cyanine dyes for NIR-II imaging has attracted increasing research interest. The bright tail emission of the present NIR-I dyes can afford high-performance NIR-II imaging with improved quantum yields (QYs) and absorption coefficients, thus accelerating the (pre-) clinical translation of NIR-II imaging. However, the quantum nature of the typically ignored but important NIR-II emission tail of cyanine dyes has never been revealed systematically, and an in-depth understanding of the fluorescence enhancement mechanism for cyanine–protein assemblies remains unclear. In this work, the quantum chemical calculations, molecular dynamics simulations, and fluorescence intensity measurements were used together to study the electronic and optical properties based on two representative cyanine dyes of ICG and IR783 with similar molecular skeletons. Distinct origins of NIR-II tail emission were identified, illustrating their significantly different quantum nature of the excited state: nuclear vibration versus twisted intramolecular charge transfer (TICT). Furthermore, the key roles of bovine serum albumin (BSA) protein through a supramolecular assembly strategy in building high-performance NIR-I cyanine dyes with NIR-II imaging were revealed. A rigid conformation of cyanine with optimal torsion can be maintained in the typically inaccessible hydrophobic domains of the BSA protein to avoid completely falling into the so-called fluorescence quenching trap. Notably, the first water shell plays a dominant role in fluorescence quenching, and the dipole–dipole coupling involved in the energy transfer process between the fluorophore and water is related not only to their distance but also to the relative orientation of each water molecule with respect to the fluorophore. The present study can provide a comprehensive understanding of the nature of NIR-II tail emission for conventional NIR-I dyes and further provide a general rule to explore conventional NIR-I dyes with bright NIR-II tail emission for NIR-II imaging.
    Type of Medium: Online Resource
    ISSN: 2050-7526 , 2050-7534
    URL: Article
    DOI: 10.1039/D3TC00452J
    Language: English
    Publisher: Royal Society of Chemistry (RSC)
    Publication Date: 2023
    detail.hit.zdb_id: 2702245-6
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  • 9
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    Association of dietary fiber intake with hyperuricemia in U.S. adults
    Royal Society of Chemistry (RSC) ; 2019
    In:  Food & Function Vol. 10, No. 8 ( 2019), p. 4932-4940
    Details
    In: Food & Function, Royal Society of Chemistry (RSC), Vol. 10, No. 8 ( 2019), p. 4932-4940
    Type of Medium: Online Resource
    ISSN: 2042-6496 , 2042-650X
    URL: Article
    DOI: 10.1039/C8FO01917G
    Language: English
    Publisher: Royal Society of Chemistry (RSC)
    Publication Date: 2019
    detail.hit.zdb_id: 2578152-2
    SSG: 21
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  • 10
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    Stability and water-resistance of humidity sensors using crosslinked and quaternized polyelectrolytes films
    Elsevier BV ; 2010
    In:  Sensors and Actuators B: Chemical Vol. 145, No. 2 ( 2010-03-19), p. 680-684
    Details
    In: Sensors and Actuators B: Chemical, Elsevier BV, Vol. 145, No. 2 ( 2010-03-19), p. 680-684
    Type of Medium: Online Resource
    ISSN: 0925-4005
    URL: Article
    DOI: 10.1016/j.snb.2010.01.024
    RVK:
    ZG 1100
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2010
    detail.hit.zdb_id: 1500731-5
    detail.hit.zdb_id: 1021505-0
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