In:
Nature Communications, Springer Science and Business Media LLC, Vol. 7, No. 1 ( 2016-12-15)
Abstract:
Leprosy, a chronic infectious disease, results from the uncultivable pathogen Mycobacterium leprae ( M. leprae ), and usually progresses to peripheral neuropathy and permanent progressive deformity if not treated. Previously published genetic studies have identified 18 gene/loci significantly associated with leprosy at the genome-wide significant level. However as a complex disease, only a small proportion of leprosy risk could be explained by those gene/loci. To further identify more susceptibility gene/loci, we hereby performed a three-stage GWAS comprising 8,156 leprosy patients and 15,610 controls of Chinese ancestry. Four novel loci were identified including rs6807915 on 3p25.2 ( P =1.94 × 10 −8 , OR=0.89), rs4720118 on 7p14.3 ( P =3.85 × 10 −10 , OR=1.16), rs55894533 on 8p23.1 ( P =5.07 × 10 −11 , OR=1.15) and rs10100465 on 8q24.11 ( P =2.85 × 10 −11 , OR=0.85). Altogether, these findings have provided new insight and significantly expanded our understanding of the genetic basis of leprosy.
Type of Medium:
Online Resource
ISSN:
2041-1723
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2016
detail.hit.zdb_id:
2553671-0
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