In:
Journal of Nanomaterials, Hindawi Limited, Vol. 2015 ( 2015), p. 1-10
Abstract:
Lung surfactant (LS) plays a crucial role in regulating surface tension during normal respiration cycles by decreasing the work associated with lung expansion and therefore decreases the metabolic energy consumed. Monolayer surfactant films composed of a mixture of phospholipids and spreading additives are of optional utility for applications in lung surfactant-based therapies. A simple, minimal model of such a lung surfactant system, composed of 1,2-dipalmitoyl-sn-glycero-3-[phosphor-rac-(1-gylcerol)] (DPPG) and hexadecanol (HD), was prepared, and the surface pressure-area ( π - A ) isotherms and nanostructure characteristics of the binary mixture were investigated at the air/water interface using a combination of Langmuir-Blodgett (LB) and atomic force microscopy (AFM) techniques. Based on the regular solution theory, the miscibility and stability of the two components in the monolayer were analyzed in terms of compression modulus ( C s - 1 ) , excess Gibbs free energy ( Δ G e x c π ) , activity coefficients ( γ ), and interaction parameter ( ξ ). The results of this paper provide valuable insight into basic thermodynamics and nanostructure of mixed DPPG/HD monolayers; it is helpful to understand the thermodynamic behavior of HD as spreading additive in LS monolayer with a view toward characterizing potential improvements to LS performance brought about by addition of HD to lung phospholipids.
Type of Medium:
Online Resource
ISSN:
1687-4110
,
1687-4129
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2015
detail.hit.zdb_id:
2229480-6
Permalink