In:
FEBS Letters, Wiley, Vol. 250, No. 2 ( 1989-07-03), p. 615-618
Abstract:
The tumor promoteradaic acid binds specifically to a particulate as well as a cytosolic fraction of various mouse tissues, e.g., skin, brain, lung and colon. The K D value was 21.7 nM for receptors in the particulate fraction and 1.0 nM for those in the cytosolic fraction of mouse skin. The specific binding of [ 3 H]okadaic acid to the particulate fraction of mouse skin was inhibited dose‐dependently byadaic acid, but notaidaic acid tetramethyl ether, an inactive compound, or by other tumor promoters, such as 12‐ O ‐tetradecanoylphorbol‐13‐acetate and teleocidin. The results suggest a new pathway of tumor promotion mediated through theadaic acid receptor(s).
Type of Medium:
Online Resource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1016/0014-5793(89)80807-5
Language:
English
Publisher:
Wiley
Publication Date:
1989
detail.hit.zdb_id:
1460391-3
SSG:
12
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