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  • 1
    Online Resource
    Online Resource
    Remdesivir and three other drugs for hospitalised patients with COVID-19: final results of the WHO Solidarity randomised trial and updated meta-analyses
    Elsevier BV ; 2022
    In:  The Lancet Vol. 399, No. 10339 ( 2022-05), p. 1941-1953
    Details
    In: The Lancet, Elsevier BV, Vol. 399, No. 10339 ( 2022-05), p. 1941-1953
    Type of Medium: Online Resource
    ISSN: 0140-6736
    URL: Article
    DOI: 10.1016/S0140-6736(22)00519-0
    RVK:
    XA 10000
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2022
    detail.hit.zdb_id: 2067452-1
    detail.hit.zdb_id: 3306-6
    detail.hit.zdb_id: 1476593-7
    SSG: 5,21
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  • 2
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    Online Resource
    Association of IL – 23 R rs 7518660 Gene Polymorphism with Susceptibility and Disease Severity of Pulmonary Tuberculosis
    Universitas Airlangga ; 2022
    In:  Indonesian Journal of Tropical and Infectious Disease Vol. 10, No. 2 ( 2022-08-08), p. 93-103
    Details
    In: Indonesian Journal of Tropical and Infectious Disease, Universitas Airlangga, Vol. 10, No. 2 ( 2022-08-08), p. 93-103
    Abstract: Pulmonary Tuberculosis (TB) is a global health problem. Of all people infected with Mycobacterium tuberculosis only a small proportion develops into TB. IL 23 is the key cytokine in the pathogenesis of TB infection. This study aims to determine the association of IL-23 R rs 7518660 gene polymorphism with susceptibility and disease severity of Pulmonary TB. A case control study involved 105 people consisting of 31 drug sensitive pulmonary TB patients, 40 patients with drug-resistant pulmonary TB and 34 healthy subjects as a control. IL-23 R rs 7518660 gene polymorphism G allele increases susceptibility to both TB drug-sensitive and drug-resistant. G and A allele, AA and AG genotypes indicates (p value 〉 0.05) in correlation with disease severity based on lesion in chest x-ray and high load of Mycobacterium tuberculosis in sputum. There was a significant relationship between allele A and susceptibility to pulmonary TB with an odds ratio of 0.231. It showed that patients with A alleles (AG and AA genotypes) were at risk of developing TB by 1/0.231 = 4.33 times lower than patients with GG genotypes. Meanwhile, the relationship of the G allele with susceptibility to pulmonary TB obtained (p value 〈 0.05) and an odds ratio value of 0.127 indicating that patients with G alleles (GG and AG genotypes) were at risk of developing TB of 1/0.127 = 7.87 times higher than in patients with the AA genotype. Conclusion: We found significant correlation between IL-23 R rs 7518660 gene polymorphism G allele with susceptibility to pulmonary TB, but the result was not significant with disease severity.
    Type of Medium: Online Resource
    ISSN: 2356-0991 , 2085-1103
    URL: Article
    DOI: 10.20473/ijtid.v10i2.33118
    Language: Unknown
    Publisher: Universitas Airlangga
    Publication Date: 2022
    detail.hit.zdb_id: 3072854-X
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  • 3
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    Online Resource
    The Effect of N-Acetylcysteine as Adjuvant Therapy of Hypoxemia in COVID-19 Patients, Assessed by Interleukin-6 Level and PaO2/FiO2 Ratio
    Perhimpunan Dokter Paru Indonesia ; 2022
    In:  Jurnal Respirologi Indonesia Vol. 42, No. 3 ( 2022-07-31), p. 226-236
    Details
    In: Jurnal Respirologi Indonesia, Perhimpunan Dokter Paru Indonesia, Vol. 42, No. 3 ( 2022-07-31), p. 226-236
    Type of Medium: Online Resource
    ISSN: 2620-3162 , 0853-7704
    URL: Article
    DOI: 10.36497/jri.v42i3.227
    Language: Unknown
    Publisher: Perhimpunan Dokter Paru Indonesia
    Publication Date: 2022
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  • 4
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    Online Resource
    Cytokine Storm score (CSs) in COVID-19 Patients Smokers at Dr. Saiful Anwar Malang
    RSUP Dr. Kariadi Semarang ; 2023
    In:  Medica Hospitalia : Journal of Clinical Medicine Vol. 10, No. 2 ( 2023-07-31), p. 217-223
    Details
    In: Medica Hospitalia : Journal of Clinical Medicine, RSUP Dr. Kariadi Semarang, Vol. 10, No. 2 ( 2023-07-31), p. 217-223
    Abstract: Background: After 3 years of the COVID-19 pandemic, its escalation is still causing a critical global health problem. Cytokine storm is a severe complication of COVID-19, and smoking is a risk factor for death. The prevalence of smoking in Indonesia is very high, but there is still little research on the effect of smoking on the occurrence of cytokine storms. The Cytokines Storm Score (CSs) is a quick and simple method for detecting cytokine storms early by utilizing D-dimer, lactate dehydrogenase (LDH), ferritin, and C-reactive protein (CRP) parameters. Objective: To evaluate CSs in COVID-19 patients smokers Methods: Retrospective analysis of 120 confirmed COVID-19 patients in November 2020–2021, divided into 2 groups (60 smokers and nonsmokers), male, without comorbidities. analysis using Chi-square and Mann-Whitney. Prior to the CSs examination, lymphopenia is required. CSs were positive if at least two of the D-dimer, LDH, or ferritin levels were elevated. The CRP level is measured if there is an increase in only one of these values. Elevated CRP, lymphopenia, and impaired D-Dimer, LDH, or ferritin will result in positive CSs. Results: CSs were significantly higher in smokers than non-smokers (54.5% vs. 45.5%, p = 0.024). D-dimer and CRP levels were significantly higher in smokers than non-smokers (1620 ng/mL vs. 1002.5 ng/mL, p = 0.001; and 13.8 mg/dL vs. 7.75 mg/dL, p = 0.001). Lower LDH and higher ferritin levels were not significant in smokers compared to nonsmokers (405.5 IU/L vs. 418 IU/L, p = 0.160; and 886.65 ng/mL vs. 790.5 ng/mL, p = 0.203). Conclusion: Cytokines Storm scores (CSs) increased significantly in COVID-19 patients who smoked, D-dimer and CRP levels were significantly higher in smoking COVID-19 patients compared to non-smokers
    Type of Medium: Online Resource
    ISSN: 2685-7898 , 2301-4369
    URL: Issue
    URL: Article
    DOI: 10.36408/mhjcm.v10i2
    DOI: 10.36408/mhjcm.v10i2.902
    Language: Unknown
    Publisher: RSUP Dr. Kariadi Semarang
    Publication Date: 2023
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  • 5
    Online Resource
    Online Resource
    Association of IL-6 rs1800796 Gene Polymorphism on Susceptibility to Pulmonary Tuberculosis
    Universitas Airlangga ; 2022
    In:  Jurnal Respirasi Vol. 8, No. 2 ( 2022-05-31), p. 81-86
    Details
    In: Jurnal Respirasi, Universitas Airlangga, Vol. 8, No. 2 ( 2022-05-31), p. 81-86
    Abstract: Introduction: Tuberculosis (TB) is still the leading cause of mortality and morbidity around the globe, particularly in underdeveloped nations. Indonesia is listed as the country with the second-largest TB burden in the world according to Global TB Report 2020. Only 10% of those infected with Mycobacterium tuberculosis (MTB) develop active TB and the great majority continues to stay latently infected, indicating that the host response to MTB may be genetically controlled at each stage. A growing number of studies have shown that numerous host genetic variables have a role in TB susceptibility. IL-6 is a pro-inflammatory cytokine produced by monocytes, endothelial cells, and fibroblasts that stimulates B and T lymphocytes while also controlling the immune response to TB. This study investigated the association of IL-6 rs1800796 gene polymorphism on susceptibility to pulmonary TB in drug-sensitive (DS) or drug-resistant (DR) patients. Methods: The case-control study involved 71 cases and 34 controls. Blood samples were taken from all study participants at Dr. Saiful Anwar General Hospital, Malang between August 2020 and February 2021. To determine SNPs, blood samples were used in a genotyping investigation using the PCR-Multiplex technique. Results: The genotype association of IL-6 rs1800796 (G/G, G/C, C/C) and allele frequency for patients and controls of IL-6 rs1800796 with susceptibility to pulmonary TB were insignificant (p 〉 0.05). Conclusion: This study found no evidence of association of IL-6 rs1800796 gene polymorphism with susceptibility to pulmonary TB.
    Type of Medium: Online Resource
    ISSN: 2621-8372 , 2407-0831
    URL: Article
    DOI: 10.20473/jr.v8-I.2.2022.81-86
    Language: Unknown
    Publisher: Universitas Airlangga
    Publication Date: 2022
    detail.hit.zdb_id: 3106747-5
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  • 6
    Online Resource
    Online Resource
    Association of Interleukin-2 (IL-2) Levels With Acid-Fast Bacillus (AFB) Sputum Conversion In Drug-Resistant Pulmonary Tuberculosis Patient
    Perhimpunan Dokter Paru Indonesia ; 2022
    In:  Respiratory Science Vol. 3, No. 1 ( 2022-09-15), p. 1-13
    Details
    In: Respiratory Science, Perhimpunan Dokter Paru Indonesia, Vol. 3, No. 1 ( 2022-09-15), p. 1-13
    Abstract: Background: Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis (Mtb) which can be found on multiple organs, but mostly infect the lung. AFB smear is used to diagnose and evaluate therapy response, to show bacterial burden and the patient’s infectious status. Combination of antituberculosis drugs for a long period of time could cause poor compliance and increased risk of resistance. Mtb infection induce immune response and release cytokines, one of which is interleukin-2 (IL-2) that regulate T lymphocyte cell. Higher IL-2 levels is found on patient with high bacterial burdern.  This study aims to see the assossciation between IL-2 levels before and 30 days after DR-TB treatment, to see pre and post-treatment IL-2 levels with conversion of AFB smear, and correlation between pre-treatment IL-2 levels and AFB smear. Method: This was a cohort prospective study at RSUD dr Saiful Anwar Malang. Thirty nine DR-TB patients underwent AFB smear before and 30 days after treatment, while IL-2 levels was also measured by Enzym-Linked Immunosorbent Assay (ELISA) technique. Results: The levels of IL-2 before treatment was significantly higher compared to 30 days after treatment (P 〈 0.001). There was no significant IL-2 levels difference between conversion and non-conversion group (P=0.23), and a weak, not-significant correlation between IL-2 levels and AFB smear (r=0.28; P=0.06). Conclusion: The levels of IL-2 was significantly higher before than after treatment and it cannot be used to determine the positivity of acid-resistant bacilli smears in the sputum of patients with DR-TB. The limited timeframe and biomarker in this study raise the possibility to observe IL-2 as well as other biomarkers after intensive phase of TB treatment for future studies.
    Type of Medium: Online Resource
    ISSN: 2747-1306
    URL: Article
    DOI: 10.36497/respirsci.v3i1.52
    Language: Unknown
    Publisher: Perhimpunan Dokter Paru Indonesia
    Publication Date: 2022
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  • 7
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    Online Resource
    Adhesiolysis and Decortication for Reccurent Hydropneumothorax Associated with Pleural Tuberculosis
    Brawijaya University ; 2021
    In:  Malang Respiratory Journal Vol. 3, No. 2 ( 2021-10-21), p. 157-161
    Details
    In: Malang Respiratory Journal, Brawijaya University, Vol. 3, No. 2 ( 2021-10-21), p. 157-161
    Abstract: Introduction: Pleural tuberculosis is a pleural infection of tuberculosis caused by Mycobacterium tuberculosis which commonly manifests as hydropneumothorax. Initial treatment with anti-tuberculosis drugs is aimed to prevent progression of the disease and relieve patient’s symptoms. Indication of adhesiolysis and decortication is to remove layer of fibrous tissue and allow the lung to reexpand.Case: A 60 year old woman with shortness of breath, cough, and right-sided chest pain. She had a history of treatment with first-line anti-tubercular drugs for a year stop in September 2016. She was identified with recurrent right-sided hydropneumothorax by chest imaging and thorax CT-scan. Adhesiolysis and decortication were performed on her. Two months later she was diagnosed again with recurrent right-sided hydropneumothorax. VATS (Video-Assisted Thoracoscopic Surgery) revealed fistula involving inferior lobe of the lung. Then, she was treated with second-line anti tuberculosis drugs. After four times reccurent hydropneumothorax, patient showed significant improvement in clinical condition, radiology finding, and lung function test after she finished the tuberculosis treatment.Discussion: Definitive diagnosis of pleural tuberculosis is by the finding of mycobacterium tuberculosis in pleural biopsy, or Mtb culture, and it was difficult to perform. In this case pleural fluid analysis revealed that cause of recurrent right-sided hydropneumothorax was tuberculosis infection.Summary: A 60 year old woman with four times reccurent right-sided hydropneumothorax, and the pleural fluid analysis suggested it was tuberculosis infection. Providing anti-tuberculosis medication based on clinically diagnosed tuberculosis based on flowchart of tuberculosis diagnosis from national tuberculosis programmed are essential to prevent progression of the disease.
    Type of Medium: Online Resource
    ISSN: 2722-6492 , 2745-7842
    URL: Article
    DOI: 10.21776/ub.mrj.2021.003.02.2
    Language: Unknown
    Publisher: Brawijaya University
    Publication Date: 2021
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  • 8
    Online Resource
    Online Resource
    Patient with Infiltrating Ductal Cell Carcinoma Mammae with Lung Tuberculosis and Nontuberculous Mycobacteria
    Brawijaya University ; 2021
    In:  Malang Respiratory Journal Vol. 3, No. 2 ( 2021-10-21), p. 162-171
    Details
    In: Malang Respiratory Journal, Brawijaya University, Vol. 3, No. 2 ( 2021-10-21), p. 162-171
    Abstract: Introduction:. Infection caused by NTM has a prevalence which varies between 4.1 and 14.1 per 100,000 patients per year. Female has a higher prevalence of NTM disease than male, which is increasing with age, and more common in Western and Southeast Asian countries.Case Description: A 42-year-old female patient has the clinical symptoms of hemoptysis, asphyxia, angina, fever, nocturnal hyperhidrosis, loss of weight and appetite for nearly 10 years. Based on the physical examination, radiology, microbiology and anatomic pathology, this patient has been diagnosed with Ca mammae with Pulmonary TB, and currently is infected by recurrent NTM.Discussion: Symptoms of nonspecific NTM often complicate the diagnosis of TNM. General symptoms such as chronic cough, increased sputum production, dyspnea, fever that is not too high, weakness, weight loss so that it overlaps with other pulmonary symptoms. In NTM, radiologicalmanifestations generally show bronchiectasis, nodular lesions, cavitary lesions and parenchymal consolidation. The choice of therapy in disease caused by NTM depends on three factors: the type of clinical presentation, the species of NTM causing the disease and the immune status of the patient.
    Type of Medium: Online Resource
    ISSN: 2722-6492 , 2745-7842
    URL: Article
    DOI: 10.21776/ub.mrj.2021.003.02.3
    Language: Unknown
    Publisher: Brawijaya University
    Publication Date: 2021
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  • 9
    Online Resource
    Online Resource
    Tuberculous Dactilitis in Young Male, a Rare Case
    Brawijaya University ; 2023
    In:  Malang Respiratory Journal Vol. 5, No. 2 ( 2023-09-25), p. 320-328
    Details
    In: Malang Respiratory Journal, Brawijaya University, Vol. 5, No. 2 ( 2023-09-25), p. 320-328
    Abstract: Introduction : Chylothorax is an uncommon medical condition caused by the accumulation of chylous fluid in the pleural space. Chylothorax has no predilection for sex or age. The prevalence after various cardiothoracic surgeries is 0.2% to 1%. Mortality and morbidity rates are around 10%. Respiratory distress may occur due to compression of the lung by the accumulated fluid. Management and approaches to treating the condition require multidisciplinary therapy, starting from non-pharmacological, pharmacological, to interventional management. Case Report : A 57-year-old Man patient was referred to the emergency room with chief complaint of shortness of breath. Reduced breathing sound on both lung fields. No previous history of cancer or thoracic surgery were found. X-ray examination had found bilateral pleural effusion. Thoracocentesis and pleural fluid analysis was performed with total of 6800 cc serosanguinous, whitish fluid was extracted from both of the lung. The patient was diagnosed with chylothorax. Lymphangiography and embolization was performed on the leak on left thoracic duct (T10) from right lymph node. Antibiotic was also given to treat the community acquired pneumonia that could be one of the possible etiology on this patient. Dietary modification with low fat diet and Ocreotide was also given to this patient as one of the treatment modalities. Discussion : The diagnosis of Chylothorax on this patient was established based on pleural fluid analysis and evidenced by lymphangiography examination by the presence of a leak in the thoracic lymphatic duct. Various modalities to  diagnose this condition have been carried out with inconclusive results. Non-pharmacological, pharmacological and radiological interventions with embolization through lymphangiography are proven to be able to stop leaks and reduce symptoms in this patient. Conclusion : Chyle leak to the pleural space may compress the lung and cause respiratory distress. Combinaton of thoracocentesis, embolization of the leakage, dietary intake modification and administration of ocreotide may help prevent further chylous fluid accumulation.
    Type of Medium: Online Resource
    ISSN: 2722-6492 , 2745-7842
    URL: Issue
    URL: Article
    DOI: 10.21776/ub.mrj.2023.005.02.1
    DOI: 10.21776/ub.mrj.2023.005.02.02
    Language: Unknown
    Publisher: Brawijaya University
    Publication Date: 2023
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  • 10
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    Kadar Prokalsitonin dan Interleukin-6 sebagai Penanda Prognostik pada Pasien Pneumonia dengan Sepsis
    Brawijaya University ; 2019
    In:  Jurnal Kedokteran Brawijaya Vol. 30, No. 4 ( 2019-08-30), p. 267-271
    Details
    In: Jurnal Kedokteran Brawijaya, Brawijaya University, Vol. 30, No. 4 ( 2019-08-30), p. 267-271
    Abstract: Pneumonia merupakan sepuluh besar kasus rawat inap dengan tingkat kematian 7,6%. Pneumonia dengan sepsis membutuhkan terapi suportif dan perawatan intensif karena tingkat kematian tinggi. Untuk memperbaiki kualitas perawatan dan hasil terapi yang lebih baik, perlu pengkajian dini diagnostik maupun prognostik. Prokalsitonin (PCT) dan Interleukin-6 (IL-6) merupakan penanda infeksi berat dan sepsis. Tujuan penelitian ini untuk menganalisa apakah PCT dan IL-6 dapat digunakan bersama-sama untuk menentukan prognosis pasien pneumonia dengan sepsis dalam hubungannya dengan status mortalitas pada hari ke-30. Penelitian kohort dilakukan pada Oktober 2018 dilakukan di Rumah Sakit Saiful Anwar, Malang, melibatkan 40 pasien pneumonia dengan sepsis tanpa diabetes, kanker, HIV dan kehamilan. Sequential Organ Failure Assesment (SOFA) score dihitung dan sampel darah diambil pada hari ke-0 dan ke-5 perawatan untuk mengukur kadar PCT dan IL-6. Status mortalitas pasien dilihat pada hari ke-30 sejak masuk rumah sakit. Dari 40 pasien, 23 pasien hidup (57,5%) dan 17 pasien meninggal (47,5%). Perbandingan antara kelompok hidup dan meninggal menunjukan perbedaan bermakna dan secara signifikan berhubungan dengan mortalitas pada SOFA score hari ke-5 (p 〈 0,001; OR: 78,75, CI 95% (9,948-623,414)), kadar IL-6 hari ke-5 (p 〈 0,05; OR: 9,208, CI 95% (2,146-39,521)) dan kadar PCT hari ke-5 (p 〈 0,05; OR: 4,190, CI 95% (1,104-15,901)). Hasil uji regresi logistik, didapatkan bahwa IL-6 hari ke-5 dan SOFA score hari ke-5 dapat digunakan sebagai faktor prognostik mortalitas pasien pneumonia dengan sepsis hari ke-30, artinya SOFA score diatas 6 dan kadar IL-6 diatas 332pg/mL pada hari ke-5, merupakan faktor penting dari kematian pasien (AUC: 0,935).
    Type of Medium: Online Resource
    ISSN: 2338-0772 , 0216-9347
    URL: Issue
    URL: Article
    DOI: 10.21776/ub.jkb.2019.030.04
    DOI: 10.21776/ub.jkb.2019.030.04.6
    Language: Unknown
    Publisher: Brawijaya University
    Publication Date: 2019
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