In:
Biomarker Insights, SAGE Publications, Vol. 2 ( 2007-01), p. 117727190700200-
Abstract:
Expression of CCR2, CXCR3 and CCR4 on CD4 + T or CD8 + T cells in blood and cerebrospinal fluid (CSF) for multiple sclerosis (MS) was measured by 3-color flow cytometry, and compared to blood from healthy controls and CSF from patients with other inflammatory neurological diseases (INDs). CD4 + CXCR3 + /CD4 + CCR4 + ratio (representing Th1/Th2 balance) was higher in both CSF and blood of MS patients than those of IND patients or healthy controls. Percentage of CCR2-positive T cells was significantly higher in CSF from MS patients. Increased CCR2 expression on T cells in CSF and Th1/Th2 imbalance may reflect the pathological processes involved in MS.
Type of Medium:
Online Resource
ISSN:
1177-2719
,
1177-2719
DOI:
10.1177/117727190700200028
Language:
English
Publisher:
SAGE Publications
Publication Date:
2007
detail.hit.zdb_id:
2256754-9
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