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  • 1
    In: BMC Geriatrics, Springer Science and Business Media LLC, Vol. 18, No. 1 ( 2018-12)
    Type of Medium: Online Resource
    ISSN: 1471-2318
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2018
    detail.hit.zdb_id: 2059865-8
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  • 2
    In: JCSM Clinical Reports, Wiley, Vol. 3, No. 1 ( 2018-01), p. 1-10
    Abstract: Hand grip strength and peak oxygen uptake (VO 2 ) are important components of frailty. However, the relationship between these two variables among community‐dwelling elderly people is still unclear. The present study aimed to investigate this relationship. Methods Participants were 190 Japanese community‐dwelling elderly outpatients (61 men and 129 women, mean age 78.0 years). Hand grip strength of participants' was measured using a Smedley‐type hand dynamometer. Peak VO 2 levels were assessed with a cardiopulmonary exercise test. Skeletal muscle mass index (SMI) and usual walking speed were assessed physiologically and physically. Sample size was calculated using G*Power 3.1.9.2. Results There were significant correlations between hand grip strength and age (r = −0.22), peak VO 2 (r = 0.40), SMI (r = 0.51), and usual walking speed (r = 0.29). There were significant differences in age, peak VO 2 and SMI after participants were divided into normal and low hand grip strength groups according to the Asian Working Group for Sarcopenia threshold, whether both sexes were combined or considered separately. Multiple logistic regression analysis showed that peak VO 2 , SMI and age were independent determinants of hand grip strength after adjusting for potential confounders (Exp(B) = 0.871; 0.475; 1.065). Longitudinal analysis after 6 months of exercise training showed the percentage of change in hand grip strength and peak VO 2 were correlated positively (r = 0.22) for 92 participants. Conclusion Peak VO 2 is independently associated with hand grip strength among community‐dwelling elderly outpatients.
    Type of Medium: Online Resource
    ISSN: 2521-3555 , 2521-3555
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 3009848-8
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  • 3
    In: Geriatrics & Gerontology International, Wiley, Vol. 17, No. 10 ( 2017-10), p. 1636-1641
    Abstract: To examine the relationship between lower limb muscle (femoral muscle, calf muscle) mass and exercise capacity, and frailty components in community‐dwelling older people. Methods Participants included 121 community‐dwelling individuals. There were 42 men and 79 women, and the mean age was 77.7 years (range 56–97 years). Appendicular skeletal muscle mass was determined using dual‐energy X‐ray absorptiometry, and the skeletal muscle index was calculated using the following formula: appendicular skeletal muscle / body height 2 . Femoral muscle mass and calf muscle mass were determined, respectively, by dividing the femoral bone and tibial bone at the knee joint space. A symptom‐limited cardiopulmonary exercise testing was carried out and peak oxygen uptake was measured. Functional exercise performance was evaluated using the handgrip strength measurement, comfortable walking speed, and the Timed Up and Go test. All patients gave written, informed consent before data collection. Results Peak oxygen uptake correlated positively with the skeletal muscle index ( r  = 0.491). Only femoral muscle mass that was corrected with the whole body muscle mass was positively correlated with peak oxygen uptake ( r  = 0.473), handgrip strength ( r  = 0.382), comfortable walking speed ( r  = 0.427), and the Timed Up and Go test ( r  = 0.379). Calf muscle mass that was corrected with the whole‐body muscle mass showed no correlation with exercise capacity and frailty components. A similar tendency was observed in both men and women. Conclusions Femoral muscle mass influenced exercise capacity and physical frail components compared with calf muscle mass. These results suggest the importance of the femoral muscle in physical frailty. Geriatr Gerontol Int 2017; 17: 1636–1641.
    Type of Medium: Online Resource
    ISSN: 1444-1586 , 1447-0594
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2078308-5
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  • 4
    In: Geriatrics & Gerontology International, Wiley, Vol. 18, No. 6 ( 2018-06), p. 833-838
    Abstract: Physical exercise improves cognitive function in people with mild cognitive impairment (MCI). However, information about whether the degree of MCI before exercise training affects improvement in cognitive function is lacking. Therefore, we aimed to investigate the cut‐off value in a MCI screening tool that predicts reversal to normal cognitive function after exercise training in older adults with MCI. Methods Participants included 112 Japanese community‐dwelling older adult outpatients (37 men, 75 women; mean age 76.3 years). We administered the Japanese version of the Montreal Cognitive Assessment (MoCA‐J) before and after exercise training. MCI was defined as a MoCA‐J score 〈 26. All participants underwent exercise training 2 days per week for 6 months, according to American Heart Association guidelines. Results The prevalence of MCI was 65.2%. After exercise training, 46.6% of participants with MCI reversed to normal cognitive function. The MoCA‐J cut‐off score to predict cognitive function potentially reversible to normal was 23, with receiver operating characteristic analysis showing an area under the curve of 0.80, sensitivity of 79.4% and specificity of 69.2%. Multiple logistic regression analysis to predict non‐MCI after exercise training showed that MoCA‐J score ≥23 (OR 6.9, P   〈  .001), female sex (OR 3.4, P  = .04) and age (OR 0.9, P  = .04) were independent determinants. Conclusions The MoCA‐J cut‐off score of 23 might be useful to predict cognitive function that is potentially reversible to normal among community‐dwelling Japanese older adults with MCI. Geriatr Gerontol Int 2018; 18: 833–838
    Type of Medium: Online Resource
    ISSN: 1444-1586 , 1447-0594
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2078308-5
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  • 5
    In: Geriatrics & Gerontology International, Wiley, Vol. 23, No. 1 ( 2023-01), p. 32-37
    Abstract: Radio‐Taiso, a traditional exercise program in Japan, may serve as a coping strategy for older adults with frailty during the COVID‐19 pandemic. This phase II trial tested program adherence and safety and explored the potential effectiveness of a home‐based Radio‐Taiso. Methods This assessor‐blind parallel randomized controlled trial included community‐dwelling Jolder Japanese adults with frailty and pre‐frailty. Fifty‐eight eligible participants were randomly allocated to intervention and control groups. Intervention participants performed 3–5‐min sessions of Radio‐Taiso one to four times per day for 12 weeks. Feasibility criteria were set at practice and retention rates of ≥75%. Safety was monitored by assessing all adverse events reported by participants during the intervention period, irrespective of causality. Potential effectiveness was exploratorily assessed using items that allow clinical interpretation of changes: mobility and health‐related quality of life (HR‐QoL), assessed using the modified short physical performance battery (SPPB) and the SF‐36, respectively. Results Both practice (83%) and retention rates (100%) met the predetermined feasibility criteria. Eleven adverse events were reported but were supposedly unrelated to the intervention. In the intention‐to‐treat analysis, there was no clinically significant difference in the change in SPPB score between groups (−0.4 points, 95% confidence interval [CI], −1.2, 0.3); however, the intervention group scored higher in the mental component of HR‐QoL than did the control group (3.4 points, 95% CI: −1.1, 7.8). Conclusions The preliminary data indicate that a phase III trial is feasible, focusing on the mental aspect of HR‐QoL as the primary outcome. Geriatr Gerontol Int 2023; 23: 32–37 .
    Type of Medium: Online Resource
    ISSN: 1444-1586 , 1447-0594
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2078308-5
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  • 6
    Online Resource
    Online Resource
    Wiley ; 1999
    In:  Electronics and Communications in Japan (Part III: Fundamental Electronic Science) Vol. 82, No. 4 ( 1999-04), p. 1-9
    In: Electronics and Communications in Japan (Part III: Fundamental Electronic Science), Wiley, Vol. 82, No. 4 ( 1999-04), p. 1-9
    Type of Medium: Online Resource
    ISSN: 1042-0967 , 1520-6440
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 1999
    detail.hit.zdb_id: 2028204-7
    detail.hit.zdb_id: 2526419-9
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  • 7
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2023
    In:  Scientific Reports Vol. 13, No. 1 ( 2023-05-16)
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 13, No. 1 ( 2023-05-16)
    Abstract: It has recently been demonstrated that reflex excitation of muscle sympathetic nerves triggered by muscle contraction contributes to the maintenance of tetanic force (TF) in rat hindlimb muscles. We hypothesized that this feedback mechanism between the contraction of hindlimb muscles and the lumbar sympathetic nerves declines during aging. In this study, we examined the contribution of sympathetic nerves on skeletal muscle contractility in young adult (4–9 months old, n = 11) and aged (32–36 months old, n = 11) male and female rats. The tibial nerve was electrically stimulated to measure the TF of the triceps surae muscles resulting from motor nerve activation before and after cutting or stimulating (at 5–20 Hz) the lumbar sympathetic trunk (LST). The TF amplitude decreased by cutting the LST in the young and aged groups; however, the magnitude of the decrease in TF following transection of the LST in the aged rats (6.2%) was significantly ( P  = 0.02) smaller compared with that in the young rats (12.9%). The TF amplitude was increased by LST stimulation at ≥ 5 Hz in the young and ≥ 10 Hz in the aged groups. The overall TF response to LST stimulation was not significantly different between the two groups; however, an increase in muscle tonus resulting from LST stimulation, independent of motor nerve stimulation, was significantly ( P  = 0.03) greater in aged compared with young rats. The sympathetic contribution to support motor nerve-induced muscle contraction declined, whereas sympathetic-mediated muscle tonus, independent of motor nerve activity, was augmented in aged rats. These changes in sympathetic modulation of hindlimb muscle contractility may underlie the reduction of skeletal muscle strength during voluntary contraction and rigidity of motion during senescence.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2615211-3
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  • 8
    In: JCSM Rapid Communications, Wiley, Vol. 4, No. 2 ( 2021-07), p. 141-149
    Abstract: Peak oxygen uptake (peak VO 2 ) is known not only as an index of aerobic fitness but also one of an index of life expectancy. Frailty, sarcopenia, and cachexia are associated with a poor prognosis and high mortality. The purpose of this study was to determine the relationships of peak VO 2 with the features of sarcopenia, frailty, and cachexia, to provide insight into which might mediate the poor prognosis. Methods The first group of participants was 175 community‐dwelling older Japanese outpatients (58 men and 117 women; mean age 77.6 ± 6.4 years), in whom we assessed the features of sarcopenia, frailty, and cachexia, and measured peak VO 2 during cardiopulmonary exercise. To confirm the relationships, we analysed another group of 162 participants (77.3 ± 5.5 years). Results There were significant correlations between peak VO 2 and the features of sarcopenia, frailty, and cachexia, with the exception of high sensitivity C‐reactive protein. Multiple linear regression analysis for the prediction of peak VO 2 (mL/min) identified following formula: predicted peak VO 2  = −11.6 × age (years) + 25.5 × haemoglobin concentration (g/dL) + 114.2 × skeletal muscle mass index (kg/m 2 ) + 8.9 × hand grip strength (kg) + 226.4 × usual walking speed (m/s) − 65.8 × fatiguability (absence 0, presence 1) − 177.4 × chronic heart failure (absence 0, presence 1) + 437.1 ( R 2  = 0.627, P   〈  0.001). The validity of the formula was confirmed with another group ( r  = 0.78, P   〈  0.001). Conclusions This study has identified the features of sarcopenia, frailty, and cachexia that are related to peak VO 2 in an older population.
    Type of Medium: Online Resource
    ISSN: 2617-1619 , 2617-1619
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 3018093-4
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  • 9
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2023
    In:  The Journal of Physiological Sciences Vol. 73, No. 1 ( 2023-03-29)
    In: The Journal of Physiological Sciences, Springer Science and Business Media LLC, Vol. 73, No. 1 ( 2023-03-29)
    Abstract: This study aimed to examine the efficacy of a 2-week self-administered gentle mechanical skin stimulation on chronic neck and shoulder discomfort. In participants ( n  = 12) with chronic neck and shoulder discomfort, subjective measures of pain sensation, discomfort, and difficulty in moving using a visual analog scale (VAS, 0–10) and objective measures of 12 different joint range of motions (ROMs) for the cervical and shoulder regions, using a digital goniometer, were collected before and after self-care with contact acupuncture, called microcones. The self-care for 2 weeks significantly ( p   〈  0.001) decreased all VAS scores to 2.2–2.3 from baseline values of 6.0–7.4. Of the 12 ROMs tested, 8 were significantly increased ( p   〈  0.013). This open-label study suggests the use of self-care with microcones in improving subjective symptoms and joint ROMs in people suffering from chronic neck and shoulder discomfort. However, a randomized, double-blind, controlled clinical trial is needed to further investigate the efficacy and safety of microcones.
    Type of Medium: Online Resource
    ISSN: 1880-6562
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2437104-X
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  • 10
    In: ESC Heart Failure, Wiley, Vol. 5, No. 5 ( 2018-10), p. 876-883
    Abstract: The association of vascular dysfunction and amyloid beta deposition attracted attentions for its relationship with cognitive decline. Previous studies show the correlation between the declined cardiac function and the cognitive impairment. In the present study, we analysed the association between cognitive functions and cardiac parameters in community‐dwelling people with preserved ejection fraction without heart failure. Methods and results Subjects were 108 Japanese community‐dwelling middle‐aged and older adults with preserved ejection fraction (25 men and 83 women; mean age 74.7 years). Cardiac functional parameters at rest were assessed with B‐type natriuretic peptide and echocardiography. The cardiopulmonary exercise test was used to test these parameters during exercise. Cognitive function was assessed with the Japanese version of the Montreal Cognitive Assessment (MoCA‐J). Other indices were assessed biochemically, physiologically, and physically. There were significant correlations between MoCA‐J score and age ( r  = −0.388), peak oxygen uptake (VO 2 , r  = 0.201), peak VO 2 /heart rate (HR, r  = 0.243), peak VO 2 /weight ( r  = 0.244), peak metabolic equivalents ( r  = 0.244), usual walking speed ( r  = −0.200), and the Timed Up and Go test ( r  = −0.230). Multiple linear regression analysis showed peak VO 2 /HR was an independent determinant of MoCA‐J score after adjusting for potential confounders ( B  = 0.424). After 6 months of exercise training with 64 subjects, we found that the per cent change of peak VO 2 /HR was related to the per cent change of MoCA‐J score ( r  = 0.296). Conclusions These results suggested that peak VO 2 /HR (an index of stroke volume at peak exercise) might be associated with cognitive impairment based on the vascular cascade hypothesis.
    Type of Medium: Online Resource
    ISSN: 2055-5822 , 2055-5822
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2814355-3
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