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  • 1
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    Online Resource
    Effectiveness and Safety of Ustekinumab in Ulcerative Colitis: Real-world Evidence from the ENEIDA Registry
    Oxford University Press (OUP) ; 2021
    In:  Journal of Crohn's and Colitis Vol. 15, No. 11 ( 2021-11-08), p. 1846-1851
    Details
    In: Journal of Crohn's and Colitis, Oxford University Press (OUP), Vol. 15, No. 11 ( 2021-11-08), p. 1846-1851
    Abstract: The development programm UNIFI has shown promising results of ustekinumab in ulcerative colitis [UC] treatment which should be confirmed in clinical practice. We aimed to evaluate the durability, effectiveness, and safety of ustekinumab in UC in real life. Methods Patients included in the prospectively maintained ENEIDA registry, who received at least one intravenous dose of ustekinumab due to active UC [Partial Mayo Score [PMS] & gt;2], were included. Clinical activity and effectiveness were defined based on PMS. Short-term response was assessed at Week 16. Results A total of 95 patients were included. At Week 16, 53% of patients had response [including 35% of patients in remission]. In the multivariate analysis, elevated serum C-reactive protein was the only variable significantly associated with lower likelihood of achieving remission. Remission was achieved in 39% and 33% of patients at Weeks 24 and 52, respectively; 36% of patients discontinued the treatment with ustekinumab during a median follow-up of 31 weeks. The probability of maintaining ustekinumab treatment was 87% at Week 16, 63% at Week 56, and 59% at Week 72; primary failure was the main reason for ustekinumab discontinuation. No variable was associated with risk of discontinuation. Three patients reported adverse events; one of them had a fatal severe SARS-CoV-2 infection. Conclusions Ustekinumab is effective in both the short and the long term in real life, even in a highly refractory cohort. Higher inflammatory burden at baseline correlated with lower probability of achieving remission. Safety was consistent with the known profile of ustekinumab.
    Type of Medium: Online Resource
    ISSN: 1873-9946 , 1876-4479
    URL: Article
    DOI: 10.1093/ecco-jcc/jjab070
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2021
    detail.hit.zdb_id: 2389631-0
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  • 2
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    Comparative Stiffness of an Equine Distal Sesamoid Bone Fracture Model Stabilized with 3.5-mm versus 4.5-mm Cortical Bone Screws in Lag Fashion
    Georg Thieme Verlag KG ; 2019
    In:  Veterinary and Comparative Orthopaedics and Traumatology Vol. 32, No. 06 ( 2019-11), p. 440-446
    Details
    In: Veterinary and Comparative Orthopaedics and Traumatology, Georg Thieme Verlag KG, Vol. 32, No. 06 ( 2019-11), p. 440-446
    Abstract: Objective The aim of this study was to to determine the comparative stiffness following repair of an axial sagittal fracture model in equine distal sesamoid bones using either a single 3.5-mm or 4.5-mm cortical bone screw placed in lag fashion. Study Design The present study was an in vitro biomechanical study. Results The mean (±standard deviation) stiffness value for the 4.5-mm screw–bone construct (522.49 N/mm ± 168.21) was significantly greater than the 3.5-mm screw-bone construct (408.46 N/mm ± 131.13) (p = 0.047). This represents a 28% difference in mean stiffness. Conclusions In vitro, the 4.5-mm screw–bone construct creates a stiffer repair of fractured distal sesamoid bones by a margin of 28%. The 4.5-mm cortical bone screw may better withstand forces imparted on the distal sesamoid bone sustained during anaesthetic recovery, normal weight bearing and athletic exercise, thereby minimizing the risk of implant failure.
    Type of Medium: Online Resource
    ISSN: 0932-0814 , 2567-6911
    URL: Article
    DOI: 10.1055/s-0039-1692979
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2019
    SSG: 22
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  • 3
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    Adaptation and evaluation of a monopolar electrosurgical triangle‐tip knife for transendoscopic ventriculocordectomy in healthy horses
    Wiley ; 2019
    In:  Veterinary Surgery Vol. 48, No. 4 ( 2019-05), p. 481-487
    Details
    In: Veterinary Surgery, Wiley, Vol. 48, No. 4 ( 2019-05), p. 481-487
    Abstract: To evaluate the efficacy and safety of a transendoscopic monopolar electrosurgical triangle‐tip knife as instrumentation to perform unilateral ventriculocordectomy (VC) in healthy adult horses. Study design In vivo experimental study. Study population Nine horses donated for medical conditions unrelated to respiratory system. Methods The triangle‐tip knife was applied in contact fashion. Left VC was performed under standing sedation. Endoscopic images of the upper airway were graded for inflammation by 2 masked surgeons preoperatively and immediately, 24 hours and, in 2 cases, 7 and 14 days postoperatively. Four larynxes were examined for histological evidence of inflammation and collagen deposition at 24 hours (n = 2) and at 14 days (n = 2) after surgery. Results Ventriculocordectomy was successfully performed in all horses. Endoscopic evidence of inflammation was scored as normal (preoperatively), mild (immediately postoperatively), mild (24 hours postoperatively), mild (7 days postoperatively), and normal (14 days postoperatively). According to histopathology, inflammation of the surgical site and ventricularis muscle was generally increased (variable is common and is present in most high‐power fields) 24 hours and 14 days postoperatively. Fibrosis and collagen deposition also seemed increased at the surgical site 14 days postoperatively. Conclusion Ventriculocordectomy was successfully performed with an electrosurgical triangle‐tip knife and resulted in acceptable short‐term outcomes. Clinical significance The use of an electrosurgical triangle‐tip knife alternative instrumentation may be offer an alternative option to perform VC in practices when diode laser is not available or is cost prohibitive. Longer term evaluation of the VC site is required to determine the effect on rima glottic cross‐sectional area.
    Type of Medium: Online Resource
    ISSN: 0161-3499 , 1532-950X
    URL: Issue
    URL: Article
    DOI: 10.1111/vsu.v48.4
    DOI: 10.1111/vsu.13154
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 1491071-8
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  • 4
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    Tenotomy of the semitendinosus muscle under standing sedation versus general anesthesia: Outcomes in 20 horses with fibrotic myopathy
    Wiley ; 2018
    In:  Veterinary Surgery Vol. 47, No. 3 ( 2018-04), p. 350-356
    Details
    In: Veterinary Surgery, Wiley, Vol. 47, No. 3 ( 2018-04), p. 350-356
    Abstract: To compare outcomes after semitendinosus tenotomy performed under standing sedation versus general anesthesia. Study Design Retrospective case series. Sample Population 20 horses with fibrotic myopathy of the semitendinosus muscle. Methods Medical records (2002‐2015) of horses undergoing tenotomy of the semitendinosus muscle for the treatment of fibrotic myopathy were reviewed. Signalment, history, affected muscles, restrain method, surgical procedures, and short‐term outcome as well as complications were retrieved from records. Long‐term outcome (gait and athletic function) was assessed at least 6 months postoperatively by conversation with the owners. Pearson's χ 2 statistical analysis was used to compare restrain method and affected muscles with overall outcome. Significance was set at P   〈  .05. Results Tenotomy of the semitendinosus muscle was performed under standing sedation in 8 horses and under general anesthesia in 12 horses. Follow‐up period ranged from 9 months to 10 years. Gait was improved to variable degrees in 8 of 14 horses when the semitendinosus muscle alone was affected and in 4 of 6 horses when both the semitendinosus and semimembranosus muscles were involved ( P  = .11). Six of 8 horses treated under standing sedation and 6 of 12 horses treated under general anesthesia exhibited some improvement in the characteristic fibrotic gait ( P  = .4473). Five of 6 athletic horses treated under standing sedation and 6 of 9 athletic horses treated under general anesthesia returned to their preinjury level of athleticism. Horses treated under standing sedation had no incisional complications; 2 of 12 horses treated under general anesthesia exhibited incisional drainage. Conclusion Tenotomy of the semitendinosus muscle in horses with fibrotic myopathy leads to similar improvement in gait, whether performed under standing sedation or general anesthesia.
    Type of Medium: Online Resource
    ISSN: 0161-3499 , 1532-950X
    URL: Issue
    URL: Article
    DOI: 10.1111/vsu.v47.3
    DOI: 10.1111/vsu.12767
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 1491071-8
    SSG: 22
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  • 5
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    Clinical and Radiographic Findings of Septic Physitis in Foals
    Georg Thieme Verlag KG ; 2020
    In:  VCOT Open Vol. 03, No. 02 ( 2020-07), p. e134-e139
    Details
    In: VCOT Open, Georg Thieme Verlag KG, Vol. 03, No. 02 ( 2020-07), p. e134-e139
    Abstract: The objective of this review is to detail the clinical and radiographic features of septic physitis in foals. Medical records were evaluated from 2008 to 2018 of cases that had septic physitis based on a combination of clinical and radiographic findings. Ten foals were diagnosed with septic physitis. In 8 of 10 foals, presence of a discrete, focal, irregular radiolucency centred on the physis and extending into the epiphysis and metaphysis was present. In the remaining two foals, subtle irregularity and diffuse radiolucency along the length of the physis was present. Three foals were able to later perform athletic function and two were sound but not in training (mean follow-up = 12 months). Overall, a distinguishing radiographic feature of septic physitis in foals is the presence of a focal radiolucency centred on the physis which is associated with the epiphysis and metaphysis consistent with osteolysis.
    Type of Medium: Online Resource
    ISSN: 2625-2325
    URL: Article
    DOI: 10.1055/s-0040-1717103
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2020
    detail.hit.zdb_id: 2934191-7
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  • 6
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    Computed tomographic features of double aortic arch in six dogs
    Wiley ; 2023
    In:  Veterinary Radiology & Ultrasound Vol. 64, No. 4 ( 2023-07), p. 669-676
    Details
    In: Veterinary Radiology & Ultrasound, Wiley, Vol. 64, No. 4 ( 2023-07), p. 669-676
    Abstract: Double aortic arch (DAA) is a rare, congenital anomaly in small animals, resulting in a complete vascular ring encircling the esophagus and trachea, and subsequent compression of these organs. Few studies have reported utilizing CT angiography (CTA) for diagnosing DAA in dogs; thus, the imaging features are currently lacking in the literature. The objectives of this retrospective, multicenter, descriptive case series were to report the clinical and CTA characteristics of DAA in surgically treated cases. Medical records and CTA images were reviewed. Six juvenile dogs met the inclusion criteria (median age: 4.2 months; range: 2–5 months). The most common clinical signs included chronic regurgitation (100%), decreased body condition (67%), and coughing (50%). Common CTA features of DAA included a dominant left aortic arch (median diameter: 8.1 mm) and minor right aortic arch (median diameter: 4.3 mm; 83%), an aberrant right subclavian artery arising directly from the right aortic arch (83%), segmental esophageal constriction (100%), and variable degrees of dilation cranial to the heart base, and marked tracheal luminal compression (median percent change: –55%; 100%) and leftward curvature of the trachea at the level of the bifurcation of the aortic arches (100%). All dogs underwent successful surgical correction with only minor postoperative complications. Due to the similarity of clinical and imaging characteristics described to that of other forms of vascular ring anomalies (VRA), CTA is vital for the specific diagnosis of DAA in dogs.
    Type of Medium: Online Resource
    ISSN: 1058-8183 , 1740-8261
    URL: Issue
    URL: Article
    DOI: 10.1111/vru.v64.4
    DOI: 10.1111/vru.13257
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2142058-0
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  • 7
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    Integrating Biophysical, Socio-Economic and Governance Principles Into Marine Reserve Design and Management in Mexico: From Theory to Practice
    Frontiers Media SA ; 2021
    In:  Frontiers in Marine Science Vol. 8 ( 2021-12-14)
    Details
    In: Frontiers in Marine Science, Frontiers Media SA, Vol. 8 ( 2021-12-14)
    Abstract: Marine conservation design and fisheries management are increasingly integrating biophysical, socio-economic and governance considerations. Integrative approaches are adopted to achieve more effective, equitable, inclusive, and robust marine policies and practices. This paper describes a participatory process to co-produce biophysical, socio-economic, and governance principles to guide the design and management of marine reserves in three regions of Mexico: the Pacific region of the Baja California Peninsula, the Gulf of California, and the Mexican Caribbean. The process of co-producing the principles included convening a coordination team, reviewing the science, convening multi-stakeholder workshops, developing and communicating the principles with key practitioners and policy makers, and supporting uptake and application to policy and practice. Biophysical principles were related to: habitat representation and risk spreading; protecting critical, special and unique areas; incorporating connectivity; allowing time for recovery; adapting to changes in climate and ocean chemistry; and considering threats and opportunities. Socio-economic principles focused on: integrating the social context, local aspirations, and human-environment interactions; considering economic and non-economic uses, promoting an equitable distribution of costs and benefits, and respecting and maintaining cultural identity and diversity. Governance principles prioritized establishing and ensuring legitimacy and institutional continuity; implementing collaborative and adaptive management; and, promoting effective management. The paper also examines early efforts to implement the principles, next steps to promote further uptake and application in Mexico, and lessons learned from the process. Thus it provides insights into a practical process and a set of principles that are valuable to inform marine conservation and fisheries management processes elsewhere.
    Type of Medium: Online Resource
    ISSN: 2296-7745
    URL: Article
    DOI: 10.3389/fmars.2021.778980
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
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  • 8
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    Validation of the RIM Score-COVID in the Spanish SEMI-COVID-19 Registry
    Springer Science and Business Media LLC ; 2023
    In:  Internal and Emergency Medicine Vol. 18, No. 3 ( 2023-04), p. 907-915
    Details
    In: Internal and Emergency Medicine, Springer Science and Business Media LLC, Vol. 18, No. 3 ( 2023-04), p. 907-915
    Type of Medium: Online Resource
    ISSN: 1828-0447 , 1970-9366
    URL: Article
    DOI: 10.1007/s11739-023-03200-3
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2378342-4
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  • 9
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    Mortality reduction in older COVID-19-patients hospitalized in Spain during the second pandemic wave from the SEMI-COVID-19 Registry
    Springer Science and Business Media LLC ; 2023
    In:  Scientific Reports Vol. 13, No. 1 ( 2023-10-18)
    Details
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 13, No. 1 ( 2023-10-18)
    Abstract: In 2020, the COVID-19 pandemic followed a two-wave pattern in most countries. Hospital admission for COVID-19 in one wave or another could have affected mortality, especially among the older persons. The objective of this study was to evaluate whether the admission of older patients during the different waves, before SARS-CoV-2 vaccination was available, was associated with a different mortality. We compared the mortality rates of patients hospitalized during 2020 before (first wave) and after (second wave) July 7, 2020, included in the SEMI-COVID-19 Registry, a large, multicenter, retrospective cohort of patients admitted to 126 Spanish hospitals for COVID-19. A multivariate logistic regression analysis was performed to control for changes in either the patient or disease profile. As of December 26, 2022, 22,494 patients had been included (17,784 from the first wave and 4710 from the second one). Overall mortality was 20.4% in the first wave and 17.2% in the second wave (risk difference (RD) − 3.2%; 95% confidence interval (95% CI) − 4.4 to − 2.0). Only patients aged 70 and older (10,973 patients: 8571 in the first wave and 2386 in the second wave) had a significant reduction in mortality (RD − 7.6%; 95% CI − 9.7 to − 5.5) (unadjusted relative risk reduction: 21.6%). After adjusting for age, comorbidities, variables related to the severity of the disease, and treatment received, admission during the second wave remained a protective factor. In Spain, patients aged 70 years and older admitted during the second wave of the COVID-19 pandemic had a significantly lower risk of mortality, except in severely dependent persons in need of corticosteroid treatment. This effect is independent of patient characteristics, disease severity, or treatment received. This suggests a protective effect of a better standard of care, greater clinical expertise, or a lesser degree of healthcare system overload.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    URL: Article
    DOI: 10.1038/s41598-023-42735-5
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
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  • 10
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    Effectiveness and safety of first-line antiretroviral regimens in clinical practice: a multicentre cohort study
    Oxford University Press (OUP) ; 2020
    In:  Journal of Antimicrobial Chemotherapy Vol. 75, No. 10 ( 2020-10-01), p. 3004-3014
    Details
    In: Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), Vol. 75, No. 10 ( 2020-10-01), p. 3004-3014
    Abstract: We compared 48 week effectiveness and safety of first-line antiretroviral regimens. Methods We analysed HIV treatment-naive adults from the Cohort of the Spanish HIV/AIDS Research Network (CoRIS) starting the most commonly used antiretroviral regimens from 2014 to 2018. We used multivariable regression models to assess the impact of initial regimen on: (i) viral suppression (VS) (viral load & lt;50 copies/mL); (ii) change in CD4 cell count; (iii) CD4/CD8 normalization ( & gt;0.4 and & gt;1); (iv) CD4 percentage normalization ( & gt;29%); (v) multiple T-cell marker recovery (MTMR: CD4  & gt; 500 cells/mm3 plus CD4 percentage & gt;29% plus CD4/CD8  & gt; 1); (vi) lipid, creatinine and transaminase changes; and (vii) discontinuations due to adverse events (AE). Results Among 3945 individuals analysed, the most frequently prescribed regimens were ABC/3TC/DTG (34.0%), TAF/FTC/EVG/CBT (17.2%), TDF/FTC + DTG (11.9%), TDF/FTC/EVG/CBT (11.7%), TDF/FTC/RPV (11.5%), TDF/FTC + bDRV (8.3%) and TDF/FTC + RAL (5.3%). At 48 weeks, 89.7% of individuals achieved VS with no significant differences by initial regimen. CD4 mean increase was 257.8 (249.3; 266.2) cells/mm3, and it was lower with TAF/FTC/EVG/CBT and TDF/FTC/RPV compared with ABC/3TC/DTG. CD4 percentage normalization was less likely with TAF/FTC/EVG/CBT, and MTMR was less likely with TAF/FTC/EVG/CBT and TDF/FTC + RAL. The proportion of discontinuations due to AE was higher with TDF/FTC + bDRV (9.7%), followed by TDF/FTC/EVG/CBT (9.5%) and TDF/FTC + DTG (7.9%). Compared with ABC/3TC/DTG, cholesterol and LDL mean increases were higher with TAF/FTC/EVG/CBT and lower with TDF/FTC + DTG, TDF/FTC/RPV and TDF/FTC + RAL. Higher mean increases in triglycerides were significantly associated with TAF/FTC/EVG/CBT. Regimens containing DTG showed higher creatinine increases. Conclusions The significantly greater immunological response and safety of some combinations may be useful for making decisions when initiating treatment.
    Type of Medium: Online Resource
    ISSN: 0305-7453 , 1460-2091
    URL: Article
    DOI: 10.1093/jac/dkaa246
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2020
    detail.hit.zdb_id: 1467478-6
    SSG: 15,3
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