In:
Journal of Cellular and Molecular Medicine, Wiley, Vol. 22, No. 9 ( 2018-09), p. 4243-4252
Abstract:
Pressure ulcer formation depends on various factors among which repetitive ischaemia/reperfusion(I/R) injury plays a vital role. Molecular hydrogen (H 2 ) was reported to have protective effects on I/R injuries of various internal organs. In this study, we investigated the effects of H 2 inhalation on pressure ulcer and the underlying mechanisms. H 2 inhalation significantly reduced wound area, 8‐oxo‐ dG level (oxidative DNA damage) and cell apoptosis rates in skin lesions. H 2 remarkably decreased ROS accumulation and enhanced antioxidant enzymes activities by up‐regulating expression of Nrf2 and its downstream components in wound tissue and/or H 2 O 2 ‐treated endothelia. Meanwhile, H 2 inhibited the overexpression of MCP ‐1 , E‐selectin , P‐selectin and ICAM ‐1 in oxidant‐induced endothelia and reduced inflammatory cells infiltration and proinflammatory cytokines ( TNF ‐α, IL ‐1, IL ‐6 and IL ‐8) production in the wound. Furthermore, H 2 promoted the expression of pro‐healing factors ( IL ‐22, TGF ‐β, VEGF and IGF 1) and inhibited the production of MMP 9 in wound tissue in parallel with acceleration of cutaneous collagen synthesis. Taken together, these data indicated that H 2 inhalation suppressed the formation of pressure ulcer in a mouse model. Molecular hydrogen has potentials as a novel and alternative therapy for severe pressure ulcer. The therapeutic effects of molecular hydrogen might be related to its antioxidant, anti‐inflammatory, pro‐healing actions.
Type of Medium:
Online Resource
ISSN:
1582-1838
,
1582-4934
DOI:
10.1111/jcmm.2018.22.issue-9
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2076114-4
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