In:
Natural Products and Bioprospecting, Springer Science and Business Media LLC, Vol. 10, No. 3 ( 2020-06), p. 153-161
Abstract:
Ten cucurbitane-type triterpene glycosides, including five new compounds named charantosides H ( 1 ), J ( 2 ), K ( 3 ), momorcharacoside A ( 4 ), goyaglycoside- l ( 5 ), and five known compounds ( 6–10 ), were isolated from the EtOAc extract of Momordica charantia fruits. The chemical structures of these compounds were identified by 1D and 2D NMR and HRESIMS spectroscopic analyses. Configurations of new compounds were determined by ROESY correlations and comparison of their 13 C NMR data with literature reported values. All compounds were evaluated for their inhibition against α -glucosidase, in which compounds 2 , 5 , 7 , 8 , 9 showed moderate inhibitory activities with IC 50 values ranging from 28.40 to 63.26 μM comparing with the positive control (acarbose, IC 50 87.65 ± 6.51 μM). Graphic Abstract
Type of Medium:
Online Resource
ISSN:
2192-2195
,
2192-2209
DOI:
10.1007/s13659-020-00241-5
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2020
detail.hit.zdb_id:
2636293-4
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