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  • 1
    Online Resource
    Online Resource
    Global multi-stakeholder endorsement of the MAFLD definition
    Elsevier BV ; 2022
    In:  The Lancet Gastroenterology & Hepatology Vol. 7, No. 5 ( 2022-05), p. 388-390
    Details
    In: The Lancet Gastroenterology & Hepatology, Elsevier BV, Vol. 7, No. 5 ( 2022-05), p. 388-390
    Type of Medium: Online Resource
    ISSN: 2468-1253
    URL: Article
    DOI: 10.1016/S2468-1253(22)00062-0
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2022
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  • 2
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    Father–Child Longitudinal Relationship: Parental Monitoring and Internet Gaming Disorder in Chinese Adolescents
    Frontiers Media SA ; 2018
    In:  Frontiers in Psychology Vol. 9 ( 2018-2-6)
    Details
    In: Frontiers in Psychology, Frontiers Media SA, Vol. 9 ( 2018-2-6)
    Type of Medium: Online Resource
    ISSN: 1664-1078
    URL: Article
    DOI: 10.3389/fpsyg.2018.00095
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2018
    detail.hit.zdb_id: 2563826-9
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  • 3
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    Several Asymptotic Bounds on the Balaban Indices of Trees
    Hindawi Limited ; 2020
    In:  Mathematical Problems in Engineering Vol. 2020 ( 2020-11-6), p. 1-6
    Details
    In: Mathematical Problems in Engineering, Hindawi Limited, Vol. 2020 ( 2020-11-6), p. 1-6
    Abstract: The Balaban index (also called the J index) of a connected graph G is a distance-based topological index, which has been successfully used in various QSAR and QSPR modeling. Although the index was introduced 30 years ago, there are few results on the asymptotic relations. In this paper, several asymptotic bounds on the Balaban indices of trees with diameters 3 and 4 are shown, respectively.
    Type of Medium: Online Resource
    ISSN: 1563-5147 , 1024-123X
    URL: Article
    DOI: 10.1155/2020/2081241
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2014442-8
    SSG: 11
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  • 4
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    Tetrandrine ameliorates cognitive deficits and mitigates tau aggregation in cell and animal models of tauopathies
    Springer Science and Business Media LLC ; 2022
    In:  Journal of Biomedical Science Vol. 29, No. 1 ( 2022-10-22)
    Details
    In: Journal of Biomedical Science, Springer Science and Business Media LLC, Vol. 29, No. 1 ( 2022-10-22)
    Abstract: Tauopathies are neurodegenerative diseases that are associated with the pathological accumulation of tau-containing tangles in the brain. Tauopathy can impair cognitive and motor functions and has been observed in Alzheimer’s disease (AD) and frontotemporal dementia (FTD). The aetiology of tauopathy remains mysterious; however, recent studies suggest that the autophagic-endolysosomal function plays an essential role in the degradation and transmission of pathological tau. We previously demonstrated that tetrandrine could ameliorate memory functions and clear amyloid plaques in transgenic AD mice by restoring autophagic-endolysosomal function. However, the efficacy of tetrandrine and the associated therapeutic mechanism in tauopathies have not been evaluated and elucidated. Methods Novel object recognition, fear conditioning and electrophysiology were used to evaluate the effects of tetrandrine on memory functions in transgenic tau mice. Western blotting and immunofluorescence staining were employed to determine the effect of tetrandrine on autophagy and tau clearance in vivo. Calcium (Ca 2+ ) imaging and flow cytometry were used to delineate the role of pathological tau and tetrandrine in lysosomal Ca 2+ and pH homeostasis. Biochemical BiFC fluorescence, Western blotting and immunofluorescence staining were used to evaluate degradation of hyperphosphorylated tau in vitro, whereas coculture of brain slices with isolated microglia was used to evaluate tau clearance ex vivo. Results We observed that tetrandrine treatment mitigated tau tangle development and corrected memory impairment in Thy1-hTau.P301S transgenic mice. Mechanistically, we showed that mutant tau expression disrupts lysosome pH by increasing two-pore channel 2 (TPC2)-mediated Ca 2+ release, thereby contributing to lysosome alkalinization. Tetrandrine inhibits TPC2, thereby restoring the lysosomal pH, promotes tau degradation via autophagy, and ameliorates tau aggregation. Furthermore, in an ex vivo assay, we demonstrated that tetrandrine treatment promotes pathological tau clearance by microglia. Conclusions Together, these findings suggest that pathological tau disturbs endolysosomal homeostasis to impair tau clearance. This impairment results in a vicious cycle that accelerates disease pathogenesis. The success of tetrandrine in reducing tau aggregation suggests first, that tetrandrine could be an effective drug for tauopathies and second, that rescuing lysosomal Ca 2+ homeostasis, thereby restoring ALP function, could be an effective general strategy for the development of novel therapies for tauopathies.
    Type of Medium: Online Resource
    ISSN: 1423-0127
    URL: Article
    DOI: 10.1186/s12929-022-00871-6
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 1482918-6
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  • 5
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    Regulation of growth temperature on structure, magnetism of epitaxial FeCo 2 O 4 films
    Royal Society of Chemistry (RSC) ; 2022
    In:  CrystEngComm Vol. 24, No. 1 ( 2022), p. 83-94
    Details
    In: CrystEngComm, Royal Society of Chemistry (RSC), Vol. 24, No. 1 ( 2022), p. 83-94
    Abstract: Epitaxial FeCo 2 O 4 films were grown by pulsed laser deposition on Al 2 O 3 (0001) substrates at different growth temperatures in this work. The growth temperature directly affects the occupation of cations and the lattice constant, resulting in different magnetic phases and conductivity. The optimal growth temperature range was 450–550 °C. Double bandgaps were observed in the UV absorption spectra. Electrical measurements showed that the film grown at 450 °C had the lowest activation energy, and the structure of this film was more ordered. The magnetic analysis demonstrated that, in addition to the ferrimagnetic phase formed by the antiparallel arrangement of the tetrahedral and octahedral magnetic moments, there were two kinds of antiferromagnetic phases. One kind of antiferromagnetism was from the antiphase boundaries, and the other was localized antiferromagnetism at the octahedra formed by the Co 2+ ions. The three kinds of magnetic phases showed different characteristics with changes in the growth temperature and measurement temperature.
    Type of Medium: Online Resource
    ISSN: 1466-8033
    URL: Article
    DOI: 10.1039/D1CE00700A
    Language: English
    Publisher: Royal Society of Chemistry (RSC)
    Publication Date: 2022
    detail.hit.zdb_id: 2025075-7
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  • 6
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    High internal phase Pickering emulsion stabilized by sea bass protein microgel particles: Food 3D printing application
    Elsevier BV ; 2022
    In:  Food Hydrocolloids Vol. 131 ( 2022-10), p. 107744-
    Details
    In: Food Hydrocolloids, Elsevier BV, Vol. 131 ( 2022-10), p. 107744-
    Type of Medium: Online Resource
    ISSN: 0268-005X
    URL: Article
    DOI: 10.1016/j.foodhyd.2022.107744
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2022
    detail.hit.zdb_id: 2026957-2
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  • 7
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    Correlation of fractalkine concentrations in serum and synovial fluid with the radiographic severity of knee osteoarthritis
    SAGE Publications ; 2013
    In:  Annals of Clinical Biochemistry: International Journal of Laboratory Medicine Vol. 50, No. 6 ( 2013-11), p. 571-575
    Details
    In: Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, SAGE Publications, Vol. 50, No. 6 ( 2013-11), p. 571-575
    Abstract: Fractalkine has been detected in synovial fluid (SF) from osteoarthritis (OA) patients. This study aims to examine the relation of fractalkine concentrations in serum and SF with the radiographic severity of OA. Methods Fractalkine concentrations of serum and SF were measured using an enzyme-linked immunosorbent assay method in 223 patients with knee OA and 165 healthy controls. The progression of OA was classified according to the Kellgren–Lawrence grading system. Results Elevated concentrations of fractalkine in serum were found in knee OA patients compared with healthy controls [all results median (interquartile range) 226.25 (183.19–259.91) vs. 127.42 (99.54–154.98) pg/mL, P  〈  0.001]. The case group included 71 knee OA patients with grade 2, 98 with grade 3, and 54 with grade 4. Knee OA patients with KL grade 4 had significantly higher fractalkine concentrations in serum and SF compared with those with KL grade 2 and 3 [serum: 247.68 (215.05–278.64) vs. 212.45 (169.19–247.96) pg/mL, P  〈  0.001, and 247.68 (215.05–278.64) vs. 222.00 (179.80–254.98) pg/mL, P = 0.005, respectively; SF: 94.95 (76.46–106.68) vs. 74.31 (63.64–84.79) pg/mL, P  〈  0.001, and 94.95 (76.46–106.68) vs. 80.34 (68.84–96.39) pg/mL, P = 0.001, respectively]. Knee OA patients with KL grade 3 showed significantly elevated concentrations of fractalkine in SF compared with those with KL grade 2 [80.34 (68.84–96.39) vs. 74.31 (63.64–84.79) pg/mL, P = 0.004] . Fractalkine concentrations in serum and SF of knee OA patients were both significantly associated with the disease severity evaluated by KL grading criteria ( r = 0.261, P  〈  0.001 and r = 0.366, P  〈  0.001, respectively). Conclusion The fractalkine concentrations in serum and SF may serve as an effective biomarker for the severity of OA.
    Type of Medium: Online Resource
    ISSN: 0004-5632 , 1758-1001
    URL: Article
    DOI: 10.1177/0004563213480494
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 2041298-8
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  • 8
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    Safety and efficacy of direct oral anticoagulation in patients with and without radiofrequency ablation of non-valvular atrial fibrillation: a multicenter retrospective cohort study
    Springer Science and Business Media LLC ; 2023
    In:  Thrombosis Journal Vol. 21, No. 1 ( 2023-04-05)
    Details
    In: Thrombosis Journal, Springer Science and Business Media LLC, Vol. 21, No. 1 ( 2023-04-05)
    Abstract: Based on the few available studies on the prognostic benefit of using direct oral anticoagulants (DOACs) after atrial fibrillation (AF) ablation. Therefore, this study aimed to evaluate the prognostic differences between patients who underwent radiofrequency ablation (RFA) and those without RFA taking DOACs. Methods This is a multicenter retrospective cohort study enrolling 6137 patients with non-valvular AF (NVAF) at 15 hospitals in China. Patient information was collected through a mean follow-up of 10 months and medical record queries. Clinical outcomes included major bleeding, total bleeding, thrombosis, all-cause death, and a composite endpoint of bleeding, thrombosis, and all-cause death. Results After adjusting for confounders and propensity score matching (PSM), patients with RFA of NVAF had a significantly lower risk of major bleeding [OR 0.278 (95% CI, 0.150-0.515), P 〈 0.001], thrombosis [OR 0.535 (95% CI, 0.316-0.908), P= 0.020] and the composite endpoint [ OR 0.835 (95% CI, 0.710-0.982), P= 0.029]. In the RFA PSM cohort, dabigatran was associated with reduced all-cause death in patients with RFA of NVAF [OR 0.420 (95% CI, 0.212-0.831), P= 0.010]. In the no RFA PSM cohort, rivaroxaban was associated with a reduction in major bleeding [OR 0.521 (95% CI, 0.403-0.673), P 〈 0.001], total bleeding [OR 0.114 (95% CI, 0.049-0.266), P 〈 0.001], and the composite endpoint [OR 0.659 ( 95% CI, 0.535-0.811), P 〈 0.001]. Conclusion Among patients with NVAF treated with DOACs, RFA was a negative correlate of major bleeding, thrombosis, and composite endpoints but was not associated with total bleeding or all-cause mortality.
    Type of Medium: Online Resource
    ISSN: 1477-9560
    URL: Article
    DOI: 10.1186/s12959-023-00483-6
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2118392-2
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  • 9
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    Table_1.DOCX
    Frontiers Media SA ; 2020
    In:  Frontiers in Genetics Vol. 11 ( 2020-11-27)
    Details
    In: Frontiers in Genetics, Frontiers Media SA, Vol. 11 ( 2020-11-27)
    Abstract: Kernel size is an important agronomic trait for grain yield in maize. The purpose of this study is to map QTLs and predict candidate genes for kernel size in maize. A total of 199 F 2 and its F 2 : 3 lines from the cross between SG5/SG7 were developed. A composite interval mapping (CIM) method was used to detect QTLs in three environments of F 2 and F 2 : 3 populations. The result showed that a total of 10 QTLs for kernel size were detected, among which were five QTLs for kernel length (KL) and five QTLs for kernel width (KW). Two stable QTLs, qKW-1 , and qKL-2 , were mapped in all three environments. Three QTLs, qKL-1, qKW-1 , and qKW-2 , were overlapped with the QTLs identified from previous studies. In order to validate and fine map qKL-2 , near-isogenic lines (NILs) were developed by continuous backcrossing between SG5 as the donor parent and SG7 as the recurrent parent. Marker-assisted selection was conducted from BC 2 F 1 generation with molecular markers near qKL-2 . A secondary linkage map with six markers around the qKL-2 region was developed and used for fine mapping of qKL-2. Finally, qKL-2 was confirmed in a 1.95 Mb physical interval with selected overlapping recombinant chromosomes on maize chromosome 9 by blasting with the Zea_Mays_B73 v4 genome. Transcriptome analysis showed that a total of 11 out of 40 protein-coding genes differently expressed between the two parents were detected in the identified qKL-2 interval. GRMZM2G006080 encoding a receptor-like protein kinase FERONIA, was predicted as a candidate gene to control kernel size. The work will not only help to understand the genetic mechanisms of kernel size of maize but also lay a foundation for further fine mapping and even cloning of the promising loci.
    Type of Medium: Online Resource
    ISSN: 1664-8021
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fgene.2020.603920
    DOI: 10.3389/fgene.2020.603920.s001
    DOI: 10.3389/fgene.2020.603920.s002
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2020
    detail.hit.zdb_id: 2606823-0
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  • 10
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    Image_2.pdf
    Frontiers Media SA ; 2022
    In:  Frontiers in Immunology Vol. 13 ( 2022-3-2)
    Details
    In: Frontiers in Immunology, Frontiers Media SA, Vol. 13 ( 2022-3-2)
    Abstract: Parkinson’s Disease (PD) is a neurodegenerative disease that affects the elderly. It is associated with motor dysfunction due to the accumulation of misfolded or aggregated fibrillar alpha-synuclein (α-syn) in the mid-brain. Current treatments are mainly focused on relieving the symptoms but are accompanied by side effects and are limited in halting disease progression. Increasing evidence points to peripheral immune cells underlying disease development, especially T cells contributing to α-syn-related neuroinflammation in PD. The onset of these cells is likely mediated by dendritic cells (DCs), whose role in α-syn-specific responses remain less studied. Moreover, Traditional Chinese medicine (TCM)-derived compounds that are candidates to treat PD may alleviate DC-T cell-mediated immune responses. Therefore, our study focused on the role of DC in response to fibrillar α-syn and subsequent induction of antigen-specific T cell responses, and the effect of TCM Curcumin-analog C1 and Tripterygium wilfordii Hook F-derived Celastrol. We found that although fibrillar α-syn did not induce significant inflammatory or T cell-mediating cytokines, robust pro-inflammatory T cell responses were found by co-culturing fibrillar α-syn-pulsed DCs with α-syn-specific CD4 + T cells. Celastrol, but not C1, reduced the onset of pro-inflammatory T cell differentiation, through promoting interaction of endosomal, amphisomal, and autophagic vesicles with fibrillar α-syn, which likely lead to its degradation and less antigen peptides available for presentation and T cell recognition. In conclusion, regulating the intracellular trafficking/processing of α-syn by DCs can be a potential approach to control the progression of PD, in which Celastrol is a potential candidate to accomplish this.
    Type of Medium: Online Resource
    ISSN: 1664-3224
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fimmu.2022.833515
    DOI: 10.3389/fimmu.2022.833515.s001
    DOI: 10.3389/fimmu.2022.833515.s002
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2606827-8
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