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  • 1
    In: Surgery Research and Practice, Hindawi Limited, Vol. 2019 ( 2019-01-02), p. 1-8
    Abstract: Purpose . To present the feasibility, safety, and efficacy of carotid endarterectomy in patients with type II internal carotid artery occlusions, including the long-term outcomes. Methods . From March 2008 to August 2015, 74 consecutive patients (48 men with a mean age of 65.1 ± 8.06 years) underwent carotid endarterectomy because of internal carotid artery (ICA) segmental occlusions. These were verified with preoperative carotid duplex scans (CDS) and CT angiography (CTA). Also, brain CT scanning was performed in all these patients. The indication for treatment was made jointly by a vascular surgeon, neurologist, and an interventional radiologist in a multidisciplinary team (MDT) context. After successful treatment, all the patients were followed-up at 1, 3, 6, and 12 months, then every 6 months thereafter. Results . The most common symptom at presentation was transient ischaemic attack (TIA) in 49 patients (66.2%), followed by stroke in the past six months in the 17 remaining patients (23%). Revascularisation of the ICA with endarterectomy techniques was performed successfully in all the patients with an average clamp time of 11.9 min. All the procedures were performed under general anaesthesia in combination with a superficial cervical block. The early complication rate was 8.1% and included two cardiac events (2.7%) (one rhythm disorder and one acute coronary syndrome), three TIAs (4.1%), and one intracerebral hemorrhage (1.3%). Only one patient with the intracerebral hemorrhage died 5 days after surgery giving a postoperative mortality of 1.3% for this series. During the follow-up period (mean 50.4 ± 31.3 months), the primary patency rates at 1, 3, 5, and 7 years were 98.4%, 94.9%, 92.9%, and 82.9%, respectively. Likewise, the survival rates were 98.7%, 96.8%, 89%, and 77.6%, respectively. Ultrasound Doppler controls during follow-up detected 8 ICA restenoses; however, only 3 of these patients required further endovascular treatment. Conclusions . Carotid endarterectomy of internal carotid artery (ICA) segmental occlusion is a safe and effective procedure associated with acceptable risk and good long-term results. Therefore, the current guidelines which do not recommend carotid endarterectomy in this patient group should be reassessed, with the requirement for ongoing large-scale randomized controlled trials to compare CEA with best medical therapy in this patient cohort.
    Type of Medium: Online Resource
    ISSN: 2356-7759 , 2356-6124
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2775994-5
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  • 2
    Online Resource
    Online Resource
    Journal of Infection in Developing Countries ; 2016
    In:  The Journal of Infection in Developing Countries Vol. 10, No. 06 ( 2016-06-30), p. 643-656
    In: The Journal of Infection in Developing Countries, Journal of Infection in Developing Countries, Vol. 10, No. 06 ( 2016-06-30), p. 643-656
    Abstract: Introduction: Candida spp. frequently cause hospital-acquired bloodstream infections (BSI) with a high mortality rate (up to 70%). We analyzed the frequency, infection characteristics, potential predisposing factors, susceptibility to antifungal drugs, biofilm production and other virulence characteristics of Candida spp. isolates obtained from a tertiary care hospital in Niš, Serbia, during a one year period. Methods: Medical histories, characteristics of isolated strains and drug susceptibility, as well as the effect on the function of isolated macrophages and other virulence features were evaluated. The obtained results were subjected to student’s t-test and multivariate statistical analyzes. Results: Herein we report an annual incidence of 3.65 cases of C. albicans, C. lusitaniae and C. lipolytica infections per 105 population. Out of eight isolated strains, two (25%) were shown to be strong biofilm producers, one (12.5%) caused hemolysis on blood agar and in two (25%) cases macrophages were able to completely eliminate the yeast colonies. Chronic kidney disease, diabetes, malignant and other diseases were present in 37.5, 62.5, 50 and 75%, respectively, in the study group. All patients with Candida BSI received antifungal therapy (amphotericin B), however, hospital mortality was observed in 25% of patients. Conclusions: Evaluation of local Candida epidemiology, antifungal susceptibility and virulence factors, as well as personalized patient risk factors are important for the surveillance of Candida BSI, especially in intensive care unit patients and may contribute to the improved options and outcome for patients with Candida BSI.
    Type of Medium: Online Resource
    ISSN: 1972-2680
    Language: Unknown
    Publisher: Journal of Infection in Developing Countries
    Publication Date: 2016
    detail.hit.zdb_id: 2394024-4
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  • 3
    Online Resource
    Online Resource
    Walter de Gruyter GmbH ; 2012
    In:  Open Medicine Vol. 7, No. 6 ( 2012-12-1), p. 769-774
    In: Open Medicine, Walter de Gruyter GmbH, Vol. 7, No. 6 ( 2012-12-1), p. 769-774
    Abstract: The aim of the research was to determine the intestinal carriers of C. difficile in different human population groups in Serbia. The research enrolled 877 persons with formed stools: (newborn children in maternity hospitals for up to two weeks old) (23), group A; children aged from two weeks to two years (121), group B; children aged two to 10 years (54), group C, healthy individuals aged 10 and over (516), group D; patients hospitalized for at least 48 hours (100), group E; staff of the Clinical Center in Nis, Serbia, (63), group F. The toxins A and B of C. difficile were detected by ELISA-ridascreen Clostridium difficile Toxin A/B (R — Biopharm AG, Darmstadt, Germany). The toxin A of C. difficile was detected using ColorPAC Toxin A test (BectonDickinson, New Jersey, USA). Out of the total number of persons (877), the carriers of certain types of toxin-producing strains of C. difficile were distributed as: 6.04% (A−/B−), 1.83% (A+/B+) and 0.11% (A−/B+). In most groups (5/6), the dominance of non-toxigenic (A−/B−) isolates was established, with the rate of carriers 1.75 – 30.43% depending on the group. Toxigenic isolates were prevalent only in the group F in relation to non — toxigenic (7.94% versus 4.76% of persons). In other groups, the carriers of toxigenic strains ranged from 0.00 – 17.45%. The presence of asymptomatic intestinal carriers of C. difficile in the human population, indicate the possible reservoirs and sources of infection.
    Type of Medium: Online Resource
    ISSN: 2391-5463
    Language: English
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2012
    detail.hit.zdb_id: 2829380-0
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  • 4
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2018
    In:  European Journal of Clinical Microbiology & Infectious Diseases Vol. 37, No. 6 ( 2018-6), p. 1061-1069
    In: European Journal of Clinical Microbiology & Infectious Diseases, Springer Science and Business Media LLC, Vol. 37, No. 6 ( 2018-6), p. 1061-1069
    Type of Medium: Online Resource
    ISSN: 0934-9723 , 1435-4373
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2018
    detail.hit.zdb_id: 1459049-9
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  • 5
    In: Journal of the Serbian Chemical Society, National Library of Serbia, Vol. 80, No. 3 ( 2015), p. 315-327
    Abstract: Due to a confirmed antimicrobial activity of both natural and synthetic coumarin derivatives, the present study was envisaged to provide a further insight into the antimicrobial potential of coumarins through a screening of a designed library of nine 4-(alkylamino)-3-nitrocoumarins against a panel of 24 laboratory strains and resistant (isolates) bacterial and fungal pathogens. All compounds showed some degree of strain-selective activity, that was, in some cases, very pronounced, reaching the value of 0.04 nmol/ml (i.e. 12 ng/ml) for the minimal inhibitory concentration against Candida albicans. The observed activity was higher against Gram-negative strains, among which the most susceptible strain, among both ATCC strains and clinical isolates, was Salmonella enteritidis. These results point out to a high potential of these coumarins as antimicrobials for the treatment of gastrointestinal and other infections caused by highly resistant microbial strains. Finally, a multivariate statistical analysis of the herein obtained and previous results on the antimicrobial activity of related selected coumarins was performed to allow an easier structure-activity discussion.
    Type of Medium: Online Resource
    ISSN: 0352-5139 , 1820-7421
    Language: English
    Publisher: National Library of Serbia
    Publication Date: 2015
    detail.hit.zdb_id: 2030173-X
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  • 6
    In: Acta chirurgica Iugoslavica, National Library of Serbia, Vol. 60, No. 2 ( 2013), p. 103-108
    Abstract: Prvi cilj ovog rada je prikazivanje rezultata korekcije angularnog deformiteta u predelu kolena primenom metode delimicnog presecanja kosti (hemikortikotomije) a zatim postepene distrakcije spoljnim fiksatorom. Drugi cilj je bio prikaz novog konstrukcionog resenja spoljnog fiksatora po Mitkovicu za resavanje problema korekcije varus deformiteta proksimalne tibije. Studija je radjena na Ortopedsko-traumatoloskoj klinici u Nisu na seriji od 70 pacijenata lecenih u periodu od 6,5 godina. Biomehanicko ispitivanje novog konstrukcionog resenja izvedeno je drvenom modelu tibije sa presecanjem 80% njene cirkumferencije. Ispitivanje je izvrseno na Masinskom fakultetu u Nisu. Klinicki rezultati korekcije varus i valgus deformiteta su dobijeni na seriji od 70 pacijenata. Na tibiji je izvrseno 58 hirurskih korekcija (49 varus i 9 valgus deformiteta) a na femuru 12 hirurskih korekcija (2 varus i 10 valgus deformiteta). Povrsna infekcija je bila registrovana kod 9 pacijenata i u svim slucajevima je bila sanirana bez vadjenja klinova. U toku biomehanickog ispitivanja novog konstrukcionog resenja spoljnog fiksatora dobijeni su sledeci rezultati: Pri dejstvu aksijalne sile od 690N (70kg) doslo je 0,30 mm do pomeranja proksimalnog fragmenta tibije u medijalnom delu presecanja drvenog modela tibije dok je u isto vreme do pomeranja u posteriornom delu gornjeg fragmenta modela tibije pomeranje bilo 0,26 mm. Na osnovu dobijenih rezultata moze se zakljuciti da je postepena korekcija metodom spoljne fiksacije, posle hemikortikotomije proksimalne tibije ili distalnog femura pouzdana metoda kako za korekciju varus tako i valgus deformiteta. Novo konstrukciono resenje uredjaja za spoljnu fiksaciju za korekciju varus deformiteta proksimalne tibije je sa biomehanicke tacke gledista pouzdano kako za kontrolu varus pozicije proksimalnog fragmenta tibije tako i za kontrolu njegove posteriorne pozicije.
    Type of Medium: Online Resource
    ISSN: 0354-950X , 2406-0887
    Language: English
    Publisher: National Library of Serbia
    Publication Date: 2013
    detail.hit.zdb_id: 2586634-5
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  • 7
    In: Medicinska istrazivanja, Centre for Evaluation in Education and Science (CEON/CEES), Vol. 49, No. 3 ( 2015), p. 38-43
    Abstract: Extracranial vertebral artery stenosis is an important cause of posterior circulation ischemic stroke. There are several therapeutic approaches in patients with vertebral artery (VA) stenosis, including medical, endovascular and surgical treatment. This review should summarize the literature concerning endovascular treatment (EVT) of extracranial VA stenosis. By scanning reference lists of other review articles and by searching electronic database MEDLINE by using major MESH term "vertebrobasilar insufficiency/therapy" from January 2010 to April 2015, studies that included patients of any race, age and sex with symptomatic or asymptomatic atherosclerotic stenotic VA disease were identified. Periprocedural transitory ischemic attack (TIA) and stroke, and death within 30 days of the treatment were our primary interest and symptom resolution was secondary outcome measure. We found 12 retrospective studies with prospectively collected data and one additional comparative study of VA angioplasty/stenting and medical treatment was found. Percutaneous luminal angioplasty or stenting alone, or their combinations were performed in 693 patients (726 lesions). Periprocedural TIA or stroke occurred in 14 out of 693 patients (2.0%) and 30 days mortality in 1 (0.15%). A wide range of restenosis rates (3-58%) was reported. The literature shows that EVT of extracranial VA stenosis is safe and efficient. The vast majority of patients remain symptom free after the procedure, despite the restenosis rate.
    Type of Medium: Online Resource
    ISSN: 0301-0619
    Uniform Title: Dobiti i rizici endovaskularnog tretmana pacijenata sa stenozom vertebralne arterije
    Language: English
    Publisher: Centre for Evaluation in Education and Science (CEON/CEES)
    Publication Date: 2015
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  • 8
    In: Journal of Cardiovascular Pharmacology and Therapeutics, SAGE Publications, Vol. 27 ( 2022-01-01), p. 107424842211374-
    Abstract: Ischemic postconditioning (IPCT) represents one of the several therapeutic strategies to attenuate ischemic reperfusion injury (IR) after carotid endarterectomy (CEA). We here present the first in-human study of IPCT in carotid surgery. Methods: The study represents an observational case-control study, with the data collected in our Institution carotid database. From December 2015 to December 2020, a total of 300 patients were included in our study; IPCT group consisted of 148 patients in whom ischemic postconditioning was performed while control group consisted of 152 patients in whom IPCT was not performed. Indications for IPCT technique were: severe unilateral internal carotid artery (ICA) stenosis ( 〉 90%), severe bilateral ICA stenosis ( 〉 80%), severe ICA stenosis ( 〉 80%) with contralateral ICA occlusion and ICA subocclusion. IPCT was performed by applying 6 cycles of 30 sec reperfusion (declamping of ICA)/30 sec ischemia (clamping of ICA) after finishing the procedure and initial declamping. Two groups of patients were compared in terms of occurrence of intrahospital and early postoperative stroke, TIA (transient ischemic attack) and neurologic morbidity. Results: Cumulative incidence of intrahospital postoperative stroke or TIA was significantly higher in the control group (5.3% vs 0.7%, P = .036). According to carotid plaque characteristics, patients in the IPCT group had significantly more frequent presence of heterogenous plaque, as well as ulcerated plaque, which was associated with the absence of postoperative stroke and significantly lower cumulative rate of TIA/stroke when compared to the control group (43.9% vs 8% and 47.3% vs 1.5%). During the follow-up period of 1 month after the surgery, there were no cases of stroke, TIA and deaths due to neurological causes in both groups of patients. Conclusion: Our results showed that IPCT significantly reduced the incidence of postoperative cerebral ischemic complications after CEA in high-risk patients for IR injury when compared to the control group.
    Type of Medium: Online Resource
    ISSN: 1074-2484 , 1940-4034
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2230155-0
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  • 9
    Online Resource
    Online Resource
    University of Nis ; 2018
    In:  Facta Universitatis, Series: Mathematics and Informatics Vol. 33, No. 1 ( 2018-04-15), p. 063-
    In: Facta Universitatis, Series: Mathematics and Informatics, University of Nis, Vol. 33, No. 1 ( 2018-04-15), p. 063-
    Abstract: A particular integer sequence derived by the convex polygon triangulation is introduced and investigated. After some underlying results are presented, the forbidden (or improper) integer values relative to the triangulation are concerned. It is understood that the forbidden sequences do not correspond to any triangulation. Some of their properties are presented. These properties are used to count the forbidden values, which is, finally, exploited in stating another decomposition of the Catalan number.
    Type of Medium: Online Resource
    ISSN: 2406-047X , 0352-9665
    Language: Unknown
    Publisher: University of Nis
    Publication Date: 2018
    detail.hit.zdb_id: 2216962-3
    SSG: 17,1
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  • 10
    Online Resource
    Online Resource
    Centre for Evaluation in Education and Science (CEON/CEES) ; 2017
    In:  Medicinski casopis Vol. 51, No. 3 ( 2017), p. 89-97
    In: Medicinski casopis, Centre for Evaluation in Education and Science (CEON/CEES), Vol. 51, No. 3 ( 2017), p. 89-97
    Type of Medium: Online Resource
    ISSN: 0350-1221 , 2406-0380
    Language: English
    Publisher: Centre for Evaluation in Education and Science (CEON/CEES)
    Publication Date: 2017
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