GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Online Resource
    Online Resource
    First confirmed Lymphogranuloma venereum (LGV) cases among MSM in Bulgaria, 2020–2021
    GSC Online Press ; 2022
    In:  World Journal of Advanced Research and Reviews Vol. 14, No. 3 ( 2022-06-30), p. 670-673
    Details
    In: World Journal of Advanced Research and Reviews, GSC Online Press, Vol. 14, No. 3 ( 2022-06-30), p. 670-673
    Abstract: Although the spread of Lymphogranuloma venereum (LGV) among European men who have sex with men (MSM) has been endemic since 2003, to the author’s knowledge no LGV cases have been confirmed in Bulgaria up to date and treatment in suspected LGV patients has been presumptive due to lack of diagnostic capacity. The objective of the study was to genotype C. trachomatis-positive samples from attendees of a sexual health center in Sofia from 2020-2021 in order to be able to detect LGV circulation among MSM in Bulgaria. During the study period, a total of 246 MSM were tested with commercially available nucleic acid amplification tests (NAATs) to detect C. trachomatis in first void urine (FVU), pharyngeal and rectal swabs. Thirty-one consecutive clinical samples found positive for C. trachomatis during diagnostic testing were retrospectively analyzed for the presence of C. trachomatis serovars L1-L3. LGV genovars-specific C. trachomatis DNA was detected by pmpH PCR from the same specimen. LGV genovars were confirmed with partial ompA gene sequencing. Altogether 31 C. trachomatis-positive samples (22 FVU, 1 pharyngeal and 8 rectal swabs) were successfully typed by pmpH PCR. Twenty-nine samples contained non-LGV and two samples LGV C. trachomatis types. All the LGV types were found in rectal samples. Detected L types were confirmed to be serovar L2 with ompA sequencing. The data show that LGV circulate also among Bulgarian MSM, which underscores the importance of expanding LGV testing capacity in order to better inform patient management. Enhanced surveillance and genotyping programs could help measure and monitor LGV prevalence in Bulgaria.
    Type of Medium: Online Resource
    ISSN: 2581-9615
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.30574/wjarr.2022.14.3
    DOI: 10.30574/wjarr
    DOI: 10.30574/wjarr.2022.14.3.0642
    Language: Unknown
    Publisher: GSC Online Press
    Publication Date: 2022
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    PREVALENCE OF MEASLES IGG ANTIBODIES AMONG HEALTHCARE WORKERS IN BULGARIA
    National Center of Infectious and Parasitic Diseases ; 2021
    In:  PROBLEMS of Infectious and Parasitic Diseases Vol. 49, No. 2 ( 2021-08-27), p. 14-19
    Details
    In: PROBLEMS of Infectious and Parasitic Diseases, National Center of Infectious and Parasitic Diseases, Vol. 49, No. 2 ( 2021-08-27), p. 14-19
    Abstract: Background: Healthcare workers are at greater risk of acquiring measles than the general population. Transmission occurs from infected patients to staff and from infected staff to patients and colleagues. In inpatient and outpatient settings, susceptible patients suffering from other conditions, especially the elderly and severely ill patients in intensive care units are at a high risk of severe disease or death if infected with measles. The most effective preventive measure against measles is vaccination with two doses of a measles-containing vaccine. Aim: To perform a serological assessment of the presence of measles IgG antibodies among healthcare workers. Materials and Methods: The present study involves serological testing performed on samples from persons working in hospitals and Regional Health Inspectorates in the country. Screening started in connection with a reported measles outbreak in Bulgaria in 2019, and continued into early 2020. An indirect ELISA assay for the detection of specific measles IgG antibodies in serum samples was used. Results: The tested 152 healthcare workers were from 5 regions of the country, i.e. Sofia-capital (n=87), Burgas (n=6), Blagoevgrad (n=5), Dobrich (n=8) and Pazardzhik (n=46). Anti-measles IgG antibodies were detected in 85.5% of the participants (130/152). Negative results, indicating a possible lack of protective immunity against measles, were obtained primarily in samples from persons younger than 40 years of age. Conclusion: Screening to identify healthcare workers who lack presumptive evidence of protective immunity against measles should be reinforced, especially among younger healthcare workers, in order to minimize the risk of measles both among healthcare workers and among patients.
    Type of Medium: Online Resource
    ISSN: 2815-2808 , 0204-9155
    URL: Article
    DOI: 10.58395/pipd.v49i2.64
    Language: Unknown
    Publisher: National Center of Infectious and Parasitic Diseases
    Publication Date: 2021
    detail.hit.zdb_id: 3159082-2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    DO WE KNOW RHINOVIRUSES AND THEIR CLINICAL IMPACT?
    National Center of Infectious and Parasitic Diseases ; 2021
    In:  PROBLEMS of Infectious and Parasitic Diseases Vol. 49, No. 1 ( 2021-04-16), p. 5-12
    Details
    In: PROBLEMS of Infectious and Parasitic Diseases, National Center of Infectious and Parasitic Diseases, Vol. 49, No. 1 ( 2021-04-16), p. 5-12
    Abstract: Acute respiratory infections cause significant morbidity and mortality even before the COVID-19 pandemic. Pandemic restrictions decreased circulation of many respiratory viruses but some less troubling infections such as common cold are still circulating. One of the most frequent causative agents of common cold are rhinoviruses. The fact that these pathogens have been able to slip through anti-COVID preventive measures raises the question of whether we really know this group of viruses and whether these viruses cause only common cold. The clinical impact of rhinoviruses seems to be underestimated. In searching of an answer how rhinoviruses have slipped through the anti-COVID precautions we referred to the work of infectious disease specialists, virologists and epidemiologists -much of it conducted decades before the current pandemic. A non-systematic search of the literature is performed. Some of the latest findings on rhinoviruses along with basic knowledge on their biology and clinical impact are summarized in this review.
    Type of Medium: Online Resource
    ISSN: 2815-2808 , 0204-9155
    URL: Article
    DOI: 10.58395/pipd.v49i1.50
    Language: Unknown
    Publisher: National Center of Infectious and Parasitic Diseases
    Publication Date: 2021
    detail.hit.zdb_id: 3159082-2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    MOSQUITO RESISTANCE TO INSECTICIDES IN BULGARIA : What do we know and should we worry?
    National Center of Infectious and Parasitic Diseases ; 2023
    In:  PROBLEMS of Infectious and Parasitic Diseases Vol. 51, No. 1 ( 2023-08-14), p. 46-51
    Details
    In: PROBLEMS of Infectious and Parasitic Diseases, National Center of Infectious and Parasitic Diseases, Vol. 51, No. 1 ( 2023-08-14), p. 46-51
    Abstract: Mosquitoes are a group of blood-sucking insects that plays a major role in disease transmission in both humans and animals. They can pose a heavy nuisance, or serve as vectors of numerous viruses and parasites on most continents, including Europe. The strategy for successful control of the mosquito populations relies on the use of insecticides of five different categories: organochlorines, organophosphates, carbamates, pyrethroids, and biopesticides. The extensive use of the first four classes has resulted in the development of resistance originating in various mechanisms. The main ones are metabolic resistance and genetic resistance, manifested by point mutations in the insecticide targets, resulting in limited binding of neurotoxic substances. Much data is available on mosquito insecticide resistance in Bulgaria between 1948 and 1990, but only regarding organochlorines, organophosphates and carbamates. There is no data on pyrethroid resistance, which should raise an alarm for both public health authorities and private pest control companies since the only insecticides registered for professional mosquito control nowadays are pyrethroids. Therefore, there is an urgent need for the use of modern multidisciplinary approaches to study the resistance of native and invasive species of mosquitoes to insecticides, which should be a key contribution to elucidating their role in the circulation of pathogens of humans and animals and optimizing methods for controlling their populations.
    Type of Medium: Online Resource
    ISSN: 2815-2808 , 0204-9155
    URL: Article
    DOI: 10.58395/b9qpvz39
    Language: Unknown
    Publisher: National Center of Infectious and Parasitic Diseases
    Publication Date: 2023
    detail.hit.zdb_id: 3159082-2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    Characterization of the RND-Type Multidrug Efflux Pump MexAB-OprM of the Plant Pathogen Pseudomonas syringae
    American Society for Microbiology ; 2008
    In:  Applied and Environmental Microbiology Vol. 74, No. 11 ( 2008-06), p. 3387-3393
    Details
    In: Applied and Environmental Microbiology, American Society for Microbiology, Vol. 74, No. 11 ( 2008-06), p. 3387-3393
    Abstract: In gram-negative bacteria, transporters belonging to the RND family are the transporters most relevant for resistance to antimicrobial compounds. In Pseudomonas aeruginosa , a clinically important pathogen, the RND-type pump MexAB-OprM has been recognized as one of the major multidrug efflux systems. Here, homologues of MexAB-OprM in the plant pathogens Pseudomonas syringae pv. phaseolicola 1448A, P. syringae pv. syringae B728a, and P. syringae pv. tomato DC3000 were identified, and mexAB-oprM -deficient mutants were generated. Determination of MICs revealed that mutation of MexAB-OprM dramatically reduced the tolerance to a broad range of antimicrobials. Moreover, the ability of the mexAB - oprM -deficient mutants to multiply in planta was reduced. RNA dot blot hybridization revealed growth-dependent regulation of the mexAB-oprM operon in P. syringae ; the expression of this operon was maximal in early exponential phase and decreased gradually during further growth.
    Type of Medium: Online Resource
    ISSN: 0099-2240 , 1098-5336
    URL: Article
    DOI: 10.1128/AEM.02866-07
    RVK:
    WA 15000
    Language: English
    Publisher: American Society for Microbiology
    Publication Date: 2008
    detail.hit.zdb_id: 223011-2
    detail.hit.zdb_id: 1478346-0
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 6
    Online Resource
    Online Resource
    Bulgarian General Practitioners’ Communication Styles about Child Vaccinations, Mainly Focused on Parental Decision Making in the Context of a Mandatory Immunization Schedule
    MDPI AG ; 2023
    In:  Healthcare Vol. 11, No. 18 ( 2023-09-17), p. 2566-
    Details
    In: Healthcare, MDPI AG, Vol. 11, No. 18 ( 2023-09-17), p. 2566-
    Abstract: The communication practices of general practitioners in relation with vaccines have not been a topic of wide scientific interest. In this article, we outline them in the context of Bulgaria. A representative, cross-sectional, quantitative, face-to-face survey was conducted among 358 Bulgarian general practitioners in 2022 using simple random sampling. We conducted an exploratory factor analysis using questions about the role of the GPs, which measure models of communication. Based on the factor analysis, we distinguished four communication styles. They were called: active communicator, restrictive communicator, informing communicator, and strained communicator. One-way ANOVA and the T-test were carried out to explore the connections between factor scores (communication styles) and other variables. One of the most important results in the study was that the informing physician (emphasizing the choice of the parents) was the most common model in Bulgaria. This is somewhat contradictory, because of the mandatory status of most vaccines. We found connections between the communication styles and other variables—such as the type of settlement, having a hesitant parent in the practice, recommendations of non-mandatory vaccines, and experience with vaccine-preventable diseases. On the basis of the factor analysis and analysis of relationships with other variables, we reached the conclusion that in Bulgaria, hesitant parents are not sufficiently involved in active, effective communication about vaccines by GPs.
    Type of Medium: Online Resource
    ISSN: 2227-9032
    URL: Article
    DOI: 10.3390/healthcare11182566
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2721009-1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 7
    Online Resource
    Online Resource
    Rhinovirus Genotypes Circulating in Bulgaria, 2018–2021
    MDPI AG ; 2023
    In:  Viruses Vol. 15, No. 7 ( 2023-07-22), p. 1608-
    Details
    In: Viruses, MDPI AG, Vol. 15, No. 7 ( 2023-07-22), p. 1608-
    Abstract: Rhinoviruses (RV) are one of the most common causative agents of respiratory infections, with significant socioeconomic impact. RV infections are not notifiable in Bulgaria, and little is known about the different RV genotypes circulating in the country. This study aims to investigate the diversity of RV genotypes that were circulating in Bulgaria in the period 2018–2021 in samples from ILI/ARI patients. Genotype assignment was based on sequencing and phylogenetic analysis of the 5′ untranslated region and the VP4-VP2 region. Out of a total of 1385 nasopharyngeal swabs tested, 166 were RV-positive (RV detection rate: 11.99% (166/1385)). Those with a cycle threshold 〈 25 were selected for genotyping (n = 63). RV isolates were successfully genotyped and classified into 34 genotypes within Rhinovirus A (RV-A), Rhinovirus B (RV-B) and Rhinovirus C (RV-C) species. Presumptive recombination events between the 5′UTR and VP4-VP2 regions were detected in three of the isolates. RV-A and RV-C were the prevalent RV species, with significantly more frequent detections of RV-A in the years before the COVID-19 pandemic compared to the post-pandemic period, when RV-C prevailed. The present study is the first to determine RV genotypes in Bulgaria and the circulation of RV-C has been described for the first time in the country.
    Type of Medium: Online Resource
    ISSN: 1999-4915
    URL: Article
    DOI: 10.3390/v15071608
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2516098-9
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 8
    Online Resource
    Online Resource
    Global disparities in SARS-CoV-2 genomic surveillance
    Springer Science and Business Media LLC ; 2022
    In:  Nature Communications Vol. 13, No. 1 ( 2022-11-16)
    Details
    In: Nature Communications, Springer Science and Business Media LLC, Vol. 13, No. 1 ( 2022-11-16)
    Abstract: Genomic sequencing is essential to track the evolution and spread of SARS-CoV-2, optimize molecular tests, treatments, vaccines, and guide public health responses. To investigate the global SARS-CoV-2 genomic surveillance, we used sequences shared via GISAID to estimate the impact of sequencing intensity and turnaround times on variant detection in 189 countries. In the first two years of the pandemic, 78% of high-income countries sequenced 〉 0.5% of their COVID-19 cases, while 42% of low- and middle-income countries reached that mark. Around 25% of the genomes from high income countries were submitted within 21 days, a pattern observed in 5% of the genomes from low- and middle-income countries. We found that sequencing around 0.5% of the cases, with a turnaround time 〈 21 days, could provide a benchmark for SARS-CoV-2 genomic surveillance. Socioeconomic inequalities undermine the global pandemic preparedness, and efforts must be made to support low- and middle-income countries improve their local sequencing capacity.
    Type of Medium: Online Resource
    ISSN: 2041-1723
    URL: Article
    DOI: 10.1038/s41467-022-33713-y
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2553671-0
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 9
    Online Resource
    Online Resource
    Healthcare-associated hepatitis B and C transmission to patients in the EU/EEA and UK: a systematic review of reported outbreaks between 2006 and 2021
    Springer Science and Business Media LLC ; 2022
    In:  BMC Public Health Vol. 22, No. 1 ( 2022-12-03)
    Details
    In: BMC Public Health, Springer Science and Business Media LLC, Vol. 22, No. 1 ( 2022-12-03)
    Abstract: Healthcare-associated transmission was the second most common hepatitis B (HBV) and hepatitis C (HCV) transmission route according to 2006–2012 European surveillance data, but data quality and completeness issues hinder comprehensive characterisation of this important issue. We carried out a systematic review of published literature on healthcare-associated transmission of HBV or HCV in European Union (EU) and European Economic Area (EEA) countries and the United Kingdom to complement surveillance data and identify higher-risk settings. We searched the PubMed and Embase databases and grey literature over the period January 2006 to September 2021, for publications reporting transmission events after 2000 in the EU/EEA and UK related to a healthcare setting or procedure. We collected data on the country, number of patients, setting type and route of transmission. In 65 publications from 16 countries, 43 HBV and 48 HCV events were identified resulting in 442 newly infected patients. Most events were reported from Italy (7 HBV and 12 HCV), Germany (8 HBV and 5 HCV) and the United Kingdom (8 HBV and 5 HCV). The number of patients infected from a single source within an event ranged from 1 to 53. Five large outbreaks of over 20 cases were identified, including two in Poland and one each in Belgium, Hungary and Slovakia. The majority of transmission events occurred through blood transfusions or in dialysis units. However, there were a number of outbreaks in seemingly low risk settings such as CT/MRI scanning units. A failure to adequately follow infection prevention control (IPC) precautions was reported in 30% of included studies. Healthcare-associated transmission of hepatitis B and C continues to occur in a range of community and hospital settings across EU/EEA countries and often results in large outbreaks, although the true extent of the situation cannot be fully determined due to under-reporting. Strict IPC precautions should be implemented across all healthcare settings and regularly audited, and surveillance systems strengthened and standardised to allow for comprehensive and consistent reporting of nosocomial transmission of hepatitis across the EU.
    Type of Medium: Online Resource
    ISSN: 1471-2458
    URL: Article
    DOI: 10.1186/s12889-022-14726-0
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2041338-5
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 10
    Online Resource
    Online Resource
    Single-Dose Cholera Vaccine in Response to an Outbreak in Zambia
    Massachusetts Medical Society ; 2018
    In:  New England Journal of Medicine Vol. 378, No. 6 ( 2018-02-08), p. 577-579
    Details
    In: New England Journal of Medicine, Massachusetts Medical Society, Vol. 378, No. 6 ( 2018-02-08), p. 577-579
    Type of Medium: Online Resource
    ISSN: 0028-4793 , 1533-4406
    URL: Article
    DOI: 10.1056/NEJMc1711583
    RVK:
    XA 10000
    Language: English
    Publisher: Massachusetts Medical Society
    Publication Date: 2018
    detail.hit.zdb_id: 1468837-2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...