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  • 1
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    Use of sevoflurane for anesthetic management of horses during thoracotomy
    American Veterinary Medical Association (AVMA) ; 2000
    In:  American Journal of Veterinary Research Vol. 61, No. 11 ( 2000-11-01), p. 1430-1437
    Details
    In: American Journal of Veterinary Research, American Veterinary Medical Association (AVMA), Vol. 61, No. 11 ( 2000-11-01), p. 1430-1437
    Abstract: Objective —To evaluate sevoflurane as an inhalation anesthetic for thoracotomy in horses. Animals —18 horses between 2 and 15 years old. Procedure —4 horses were used to develop surgical techniques and were euthanatized at the end of the procedure. The remaining 14 horses were selected, because they had an episode of bleeding from their lungs during strenuous exercise. General anesthesia was induced with xylazine (1.0 mg/kg of body weight, IV) followed by ketamine (2.0 mg/kg, IV). Anesthesia was maintained with sevoflurane in oxygen delivered via a circle anesthetic breathing circuit. Ventilation was controlled to maintain PaCO 2 at approximately 45 mm Hg. Neuromuscular blocking drugs (succinylcholine or atracurium) were administered to eliminate spontaneous breathing efforts and to facilitate surgery. Cardiovascular performance was monitored and supported as indicated. Results —2 of the 14 horses not euthanatized died as a result of ventricular fibrillation. Mean (± SD) duration of anesthesia was 304.9 ± 64.1 minutes for horses that survived and 216.7 ± 85.5 minutes for horses that were euthanatized or died. Our subjective opinion was that sevoflurane afforded good control of anesthetic depth during induction, maintenance, and recovery. Conclusions and Clinical Relevance —Administration of sevoflurane together with neuromuscular blocking drugs provides stable and easily controllable anesthetic management of horses for elective thoracotomy and cardiac manipulation. ( Am J Vet Res 2000;61:1430–1437)
    Type of Medium: Online Resource
    ISSN: 0002-9645
    URL: Article
    DOI: 10.2460/ajvr.2000.61.1430
    Language: Unknown
    Publisher: American Veterinary Medical Association (AVMA)
    Publication Date: 2000
    detail.hit.zdb_id: 390796-X
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  • 2
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    Assessment of halothane and sevoflurane anesthesia in spontaneously breathing rats
    American Veterinary Medical Association (AVMA) ; 2003
    In:  American Journal of Veterinary Research Vol. 64, No. 4 ( 2003-04-01), p. 470-474
    Details
    In: American Journal of Veterinary Research, American Veterinary Medical Association (AVMA), Vol. 64, No. 4 ( 2003-04-01), p. 470-474
    Abstract: Objective —To characterize halothane and sevoflurane anesthesia in spontaneously breathing rats. Animals —16 healthy male Sprague-Dawley rats. Procedure —8 rats were anesthetized with halothane and 8 with sevoflurane. Minimum alveolar concentration (MAC) was determined. Variables were recorded at anesthetic concentrations of 0.8, 1.0, 1.25, and 1.5 times the MAC of halothane and 1.0, 1.25, 1.5, and 1.75 times the MAC of sevoflurane. Results —Mean (± SEM) MAC for halothane was 1.02 ± 0.02% and for sevoflurane was 2.99 ± 0.19%. As sevoflurane dose increased from 1.0 to 1.75 MAC, mean arterial pressure (MAP) decreased from 103.1 ± 5.3 to 67.9 ± 4.6 mm Hg, and PaCO 2 increased from 58.8 ± 3.1 to 92.2 ± 9.2 mm Hg. As halothane dose increased from 0.8 to 1.5 MAC, MAP decreased from 99 ± 6.2 to 69.8 ± 4.5 mm Hg, and PaCO 2 increased from 59.1 ± 2.1 to 75.9 ± 5.2 mm Hg. Respiratory rate decreased in a dose-dependent fashion from 88.5 ± 4.5 to 58.5 ± 2.7 breaths/min during halothane anesthesia and from 42.3 ± 1.8 to 30.5 ± 4.5 breaths/min during sevoflurane anesthesia. Both groups of rats had an increase in eyelid and pupillary aperture with an increase in anesthetic dose. Conclusions and Clinical Relevance —An increase in PaCO 2 and a decrease in MAP are clinical indicators of an increasing halothane and sevoflurane dose in unstimulated spontaneously breathing rats. Increases in eyelid aperture and pupil diameter are reliable signs of increasing depth of halothane and sevoflurane anesthesia. Decreasing respiratory rate is a clinical indicator of an increasing dose of halothane. ( Am J Vet Res 2003;64:470–474)
    Type of Medium: Online Resource
    ISSN: 0002-9645
    URL: Article
    DOI: 10.2460/ajvr.2003.64.470
    Language: Unknown
    Publisher: American Veterinary Medical Association (AVMA)
    Publication Date: 2003
    detail.hit.zdb_id: 390796-X
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  • 3
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    Lower urinary tract transitional cell carcinoma in cats: Clinical findings, treatments, and outcomes in 118 cases
    Wiley ; 2020
    In:  Journal of Veterinary Internal Medicine Vol. 34, No. 1 ( 2020-01), p. 274-282
    Details
    In: Journal of Veterinary Internal Medicine, Wiley, Vol. 34, No. 1 ( 2020-01), p. 274-282
    Abstract: Lower urinary tract transitional cell carcinoma (TCC) is an important but rarely described disease of cats. Objectives To report the clinical characteristics, treatments, and outcomes in a cohort of cats with lower urinary tract TCC and to test identified variables for prognostic relevance. Animals One‐hundred eighteen client‐owned cats with lower urinary tract carcinoma. Methods Medical records were retrospectively reviewed to obtain information regarding clinical characteristics, treatments, and outcomes. Recorded variables were analyzed statistically. Results Median age of affected cats was 15 years (range, 5.0‐20.8 years) and median duration of clinical signs was 30 days (range, 0‐730 days). The trigone was the most common tumor location (32/118; 27.1%) as assessed by ultrasound examination, cystoscopy, or both. Treatment was carried out in 73 of 118 (61.9%) cats. Metastatic disease was documented in 25 of 118 (21.2%) cats. Median progression‐free survival and survival time for all cats were 113 days (95% confidence interval [CI], 69‐153) and 155 days (95% CI, 110‐222), respectively. Survival increased significantly ( P 〈  .001) when comparing cats across the ordered treatment groups: no treatment, treatment without partial cystectomy, and treatment with partial cystectomy. Partial cystectomy (hazard ratio [HR], 0.31; 95% CI, 0.17‐0.87) and treatment with nonsteroidal anti‐inflammatory drugs (HR, 0.55; 95% CI, 0.33‐0.93) were significantly associated with longer survival times. Conclusions and Clinical Importance The results support treatment using partial cystectomy and NSAIDs in cats with TCC.
    Type of Medium: Online Resource
    ISSN: 0891-6640 , 1939-1676
    URL: Issue
    URL: Article
    DOI: 10.1111/jvim.v34.1
    DOI: 10.1111/jvim.15656
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 92798-3
    detail.hit.zdb_id: 2177690-8
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  • 4
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    Choledochal stenting for treatment of extrahepatic biliary obstruction in cats
    Wiley ; 2021
    In:  Journal of Veterinary Internal Medicine Vol. 35, No. 6 ( 2021-11), p. 2722-2729
    Details
    In: Journal of Veterinary Internal Medicine, Wiley, Vol. 35, No. 6 ( 2021-11), p. 2722-2729
    Abstract: Limited information currently exists regarding the clinical progression and outcomes of cats that undergo choledochal stenting as a treatment for extrahepatic biliary obstruction (EHBO). Hypothesis/Objectives Describe clinical characteristics, indications for choledochal stent placement, procedure, and outcomes in a cohort of cats undergoing choledochal stenting and evaluate risk factors associated with survival as well as recurrence of EHBO in affected cats. Animals Twenty‐three client‐owned cats undergoing choledochal stent placement. Methods Retrospective study. Medical records from 6 academic institutions were reviewed, and data were extracted and analyzed statistically. Results Median age of cats was 10.1 years (range, 2‐16), and all cats had at least 2 clinical signs. Most common clinical signs were vomiting in 20/22 (90.9%), inappetence in 19/22 (86.4%), and lethargy in 19/23 (82.6%). Procedural complications were uncommon and rarely related to the stenting procedure. Clinical signs improved postoperatively in 15/20 (75.0%) cats and serum total bilirubin concentration decreased postoperatively in 13/19 (68.4%) cats. Eighteen (78.3%) cats survived to discharge. Recurrence of EHBO was documented in 7/18 (38.9%) cats that survived to discharge. Cholelithiasis was associated with recurrence of EHBO. Median survival time for cats that survived to discharge was 931 days (range, 19‐3034). Absence of peritoneal effusion was associated with survival to discharge. Conclusions and Clinical Importance Choledochal stenting was an effective treatment modality in cats with EHBO with few procedural complications and potential for prolonged survival, but substantial risk for recurrence of EHBO was identified.
    Type of Medium: Online Resource
    ISSN: 0891-6640 , 1939-1676
    URL: Issue
    URL: Article
    DOI: 10.1111/jvim.v35.6
    DOI: 10.1111/jvim.16176
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 92798-3
    detail.hit.zdb_id: 2177690-8
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  • 5
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    Treatment of retroperitoneal sarcoma results in improved outcomes
    American Veterinary Medical Association (AVMA) ; 2024
    In:  Journal of the American Veterinary Medical Association ( 2024-02-21), p. 1-9
    Details
    In: Journal of the American Veterinary Medical Association, American Veterinary Medical Association (AVMA), ( 2024-02-21), p. 1-9
    Abstract: To report the clinical characteristics, treatments, and outcomes in a cohort of dogs with histologically confirmed retroperitoneal sarcoma (RPS) and to identify potential variables of prognostic significance. ANIMALS 46 client-owned dogs from 10 clinics with histopathologic diagnosis of a sarcoma originating from the retroperitoneal space. METHODS Medical records were retrospectively reviewed to obtain information regarding clinical characteristics, treatments, and outcomes. Recorded variables were analyzed to report descriptive data for all cases and overall survival time. Multivariate analysis was utilized to evaluate prognostic factors for overall survival. RESULTS Hemangiosarcoma was the most common histologic subtype diagnosed (76.1%). Cytoreductive and curative intent surgical excision of the RPS was attempted in 12 and 22 dogs, respectively; 12 dogs underwent no surgery or had an exploratory laparotomy with incisional biopsy only. Nineteen dogs received adjuvant chemotherapy, either injectable or metronomic, and 1 dog received adjuvant radiation therapy. Fourteen of the 34 (41.2%) surgically treated dogs developed evidence of local recurrence, but there was no difference in local recurrence when comparing dogs categorized as curative intent versus cytoreductive surgery. The median overall survival time was 238 days. On multivariable analysis, treatment approach was associated with survival with surgical excision (vs palliative treatment) and adjuvant chemotherapy following surgery being protective against death. A diagnosis of hemangiosarcoma was associated with a greater hazard of death. CLINICAL RELEVANCE This study demonstrates a substantially greater survival time than previously published and suggests a survival benefit from surgical excision and adjuvant chemotherapy.
    Type of Medium: Online Resource
    ISSN: 0003-1488
    URL: Article
    DOI: 10.2460/javma.23.09.0507
    Language: Unknown
    Publisher: American Veterinary Medical Association (AVMA)
    Publication Date: 2024
    detail.hit.zdb_id: 390811-2
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  • 6
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    Thoracoscopic removal of cranial mediastinal masses in dogs is associated with a low conversion rate, excellent survival to discharge, and good long-term outcome
    American Veterinary Medical Association (AVMA) ; 2024
    In:  Journal of the American Veterinary Medical Association ( 2024-07-17), p. 1-8
    Details
    In: Journal of the American Veterinary Medical Association, American Veterinary Medical Association (AVMA), ( 2024-07-17), p. 1-8
    Abstract: To report the complications and outcomes associated with thoracoscopic cranial mediastinal mass resection in dogs. ANIMALS 49 client-owned dogs that underwent thoracoscopic cranial mediastinal mass removal. METHODS This was a retrospective cohort study (January 1, 2014, to July 31, 2023), and the medical records of 49 client-owned dogs that underwent thoracoscopic cranial mediastinal mass removal were reviewed. The signalment, history, clinicopathologic features, perioperative complications, and long-term outcome were recorded. RESULTS Preoperative myasthenia gravis (MG) and megaesophagus (ME) were identified in 17 of 49 (35%) dogs and 11 of 49 (22%) dogs, respectively. The median maximal tumor diameter on CT images was 4.7 cm (range, 2.7 to 8.5 cm). Nonemergent conversion to an open procedure was necessary in 4 of 49 (8%) dogs, and dogs with conversion to an open procedure had a significantly larger median maximal CT tumor diameter than dogs without conversion ( P = .03). The most common tumor type was thymoma (37/49 [76%]). The overall median survival time for dogs with thymoma was 1,102 days (95% CI, 482 to upper bound not reached). The median survival time for dogs with thymoma and concurrent presurgical MG was 182 days (95% CI, 14 to upper bound not reached). Presurgical diagnosis of MG ( P = .44) or ME ( P = .69) was not associated with survival time. CLINICAL RELEVANCE Thoracoscopic removal of cranial mediastinal masses was associated with low conversion and complication rates. Long-term survival is possible, and thoracoscopic removal should be considered for select cases.
    Type of Medium: Online Resource
    ISSN: 0003-1488
    URL: Article
    DOI: 10.2460/javma.23.12.0679
    Language: Unknown
    Publisher: American Veterinary Medical Association (AVMA)
    Publication Date: 2024
    detail.hit.zdb_id: 390811-2
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  • 7
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    Intraoperative and major postoperative complications and survival of dogs undergoing surgical management of epiglottic retroversion: 50 dogs (2003‐2017)
    Wiley ; 2019
    In:  Veterinary Surgery Vol. 48, No. 5 ( 2019-07), p. 803-819
    Details
    In: Veterinary Surgery, Wiley, Vol. 48, No. 5 ( 2019-07), p. 803-819
    Abstract: To report intraoperative and major postoperative complications in dogs treated surgically for epiglottic retroversion (ER), compare the incidence of major postoperative complications between procedures, and report survival of surgically treated dogs. Study design Multi‐institutional retrospective study. Sample population Fifty dogs treated with 78 procedures. Methods Medical records of dogs diagnosed and surgically treated for ER from 2003 to 2017 at 11 institutions were reviewed. Complications were divided into intraoperative and major postoperative complications. Results Intraoperative complications occurred during 2 of 78 (2.6%) procedures. Thirty‐six major postoperative complications were documented in 22 dogs after 36 of 74 (48.7%) procedures. Postoperative complications occurred after 7 of 12 (58.3%) nonincisional epiglottopexy, 23 of 43 (53.5%) incisional epiglottopexy, 2 of 4 (50%) partial epiglottectomy, 2 of 12 (16.7%) subtotal epiglottectomy, and 2 of 3 (66.7%) other surgical procedures. Epiglottopexy failure was the most common major postoperative complication. The incidence of major postoperative complications did not differ between procedures ( P = .1239), although, when combined, epiglottopexy procedures (30/55) had a higher incidence of complications than epiglottectomy procedures (4/16; P = .048). Thirty (60%) dogs were alive at a median of 928 days (range, 114‐2805), 8 (16%) were lost to follow‐up after 411 days (range, 43‐1158), and 12 (24%) were dead/euthanized after 301.5 days (range, 3‐1212). Median survival time was not reached after a median of 716 days. Conclusion Although intraoperative complications were uncommon, major postoperative complications were common, especially after epiglottopexy procedures. Clinical significance Although surgical treatment of ER is associated with a high rate of major postoperative complications, especially epiglottopexy procedures, long‐term survival can be achieved.
    Type of Medium: Online Resource
    ISSN: 0161-3499 , 1532-950X
    URL: Issue
    URL: Article
    DOI: 10.1111/vsu.v48.5
    DOI: 10.1111/vsu.13226
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 759964-X
    detail.hit.zdb_id: 1491071-8
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  • 8
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    Utility of bronchoscopy combined with surgery in the treatment and outcomes of dogs with intrathoracic disease secondary to plant awn migration
    Wiley ; 2019
    In:  Veterinary Surgery Vol. 48, No. 7 ( 2019-10), p. 1309-1317
    Details
    In: Veterinary Surgery, Wiley, Vol. 48, No. 7 ( 2019-10), p. 1309-1317
    Abstract: To evaluate the diagnostic and therapeutic utility of bronchoscopy in dogs undergoing computed tomography (CT) and surgery for intrathoracic disease (pyothorax and pneumothorax) secondary to migrating plant awns (MPA) and to report outcomes in dogs that did and did not undergo bronchoscopy in addition to CT and surgery. Study design Retrospective case series. Animals Thirty‐seven client‐owned dogs. Methods Medical records from 2008 to 2017 were reviewed for dogs with documented MPA in the thoracic cavity treated with CT and surgery with or without bronchoscopy. Information regarding diagnostics, treatments, complications, and outcomes relating to hospitalization was evaluated. Results At least one abnormal lung lobe was identified by CT in all dogs. Bronchial abnormalities were identified with bronchoscopy in 21 of 22 dogs (95.4%) with available reports. Agreement between CT and bronchoscopy findings ranged from 50% to 81.8%, depending on lung lobe. Thirty‐six dogs had one or more lung lobes surgically removed. Thirty‐seven MPA were retrieved via bronchoscopy in 10 of 27 (37%) dogs, and 39 MPA were retrieved at surgery in 26 of 37 (70.3%) dogs. Actinomyces spp. were cultured from surgical samples in 7 of 33 (21.2%) dogs. Thirty‐five of 37 (94.6%) dogs survived to discharge. Conclusion Migrating plant awns were successfully retrieved via bronchoscopy. Agreement between CT findings and bronchoscopy was inconsistent, so there may be roles for both modalities. Short‐ and long‐term survival was excellent in this cohort. Clinical significance Bronchoscopy may allow for diagnostic and therapeutic advantages compared with CT in dogs with endobronchial MPA. Actinomyces spp appear to be variably present in surgically acquired bacterial cultures in dogs with MPA.
    Type of Medium: Online Resource
    ISSN: 0161-3499 , 1532-950X
    URL: Issue
    URL: Article
    DOI: 10.1111/vsu.v48.7
    DOI: 10.1111/vsu.13287
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 759964-X
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  • 9
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    Laparoscopic adrenalectomy for resection of unilateral noninvasive adrenal masses in dogs is associated with excellent outcomes in experienced centers
    American Veterinary Medical Association (AVMA) ; 2023
    In:  Journal of the American Veterinary Medical Association ( 2023-08-15), p. 1-8
    Details
    In: Journal of the American Veterinary Medical Association, American Veterinary Medical Association (AVMA), ( 2023-08-15), p. 1-8
    Abstract: To report the short- and long-term outcomes of laparoscopic adrenalectomy (LA) for resection of unilateral adrenal masses and to document risk factors for conversion and peri- and postoperative morbidity. ANIMALS 255 client-owned dogs. METHODS Dogs were included if LA was attempted for resection of a unilateral adrenal mass. Medical records were evaluated and relevant data were reported, including complications, conversion, perioperative death, and long-term outcomes. Signalment, clinicopathological data, and surgical experience were factors statistically evaluated for possible associations with capsular penetration during surgery, conversion, surgical time, duration of hospital stay, death prior to discharge, mass recurrence, and survival time. RESULTS 155 dogs had left-sided tumors, and 100 had right-sided tumors. Conversion to an open approach was performed in 9.4% of cases. Capsular penetration (19.2%) and major hemorrhage (5.4%) were the most prevalent intraoperative complications. Of the dogs operated on, 94.9% were discharged from the hospital. Lesion side, portion of the gland affected, and surgeon experience influenced surgical time. Conversion rate increased with increasing body condition score and lesion size. Risk of death prior to discharge increased with increasing lesion size. Risk of conversion and death prior to discharge were lower when performed by more experienced surgeons. Capsular penetration during LA increased the risk of tumor recurrence. CLINICAL RELEVANCE LA for resection of unilateral adrenal masses is associated with excellent outcomes in experienced centers. Surgeons with greater experience with LA have lower surgical times, conversion rates, and risk of death prior to discharge.
    Type of Medium: Online Resource
    ISSN: 0003-1488
    URL: Article
    DOI: 10.2460/javma.23.03.0135
    Language: Unknown
    Publisher: American Veterinary Medical Association (AVMA)
    Publication Date: 2023
    detail.hit.zdb_id: 390811-2
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  • 10
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    Postoperative Respiratory Function and Survival After Pneumonectomy in Dogs and Cats
    Wiley ; 2016
    In:  Veterinary Surgery Vol. 45, No. 6 ( 2016-08), p. 775-781
    Details
    In: Veterinary Surgery, Wiley, Vol. 45, No. 6 ( 2016-08), p. 775-781
    Abstract: Objective: To describe indications for, and outcomes after, pneumonectomy in dogs and cats, including assessment of immediate postoperative respiratory function in comparison to dogs undergoing single lung lobectomy. Study Design: Retrospective case series. Animals: Dogs (n=16) and cats (n=7) with naturally occurring pulmonary disease. Methods: Medical records (1990–2014) of dogs and cats undergoing right or left pneumonectomy were reviewed. Data retrieved included signalment, history, preoperative diagnostics, operative descriptions, postoperative data including respiratory function, and postdischarge outcomes. For respiratory function comparisons, medical records of dogs having undergone a single lung lobectomy via median sternotomy (n=15) or intercostal thoracotomy (n=15) were reviewed. Results: Twenty‐three cases (16 dogs, 7 cats) were included. Pneumonectomy was performed for congenital (1 dog, 1 cat), neoplastic (8 dogs, 1 cat), and infectious (7 dogs, 5 cats) disease. Postoperative aspiration pneumonia occurred in 2 dogs; 15 of 16 dogs (94%) and 6/7 cats (86%) survived to hospital discharge. After pneumonectomy, dogs had a significantly higher postoperative PaO 2 on 21% oxygen ( P =.033) and lower postoperative A‐a gradient ( P =.004) compared to dogs undergoing single lung lobectomy. Survival times (right‐censored at last follow‐up) for dogs ranged from 2 days to 7 years (estimated median=1,868 days) and for cats from 1–585 days. Conclusion: Dogs and cats have acceptable respiratory function immediately postoperatively and most have protracted long‐term survival after pneumonectomy for a variety of pulmonary diseases.
    Type of Medium: Online Resource
    ISSN: 0161-3499 , 1532-950X
    URL: Issue
    URL: Article
    DOI: 10.1111/vsu.v45.6
    DOI: 10.1111/vsu.12513
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 759964-X
    detail.hit.zdb_id: 1491071-8
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