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  • 1
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2014
    In:  Sadhana Vol. 39, No. 1 ( 2014-2), p. 97-121
    In: Sadhana, Springer Science and Business Media LLC, Vol. 39, No. 1 ( 2014-2), p. 97-121
    Type of Medium: Online Resource
    ISSN: 0256-2499 , 0973-7677
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2014
    detail.hit.zdb_id: 2097680-X
    SSG: 11
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  • 2
    Online Resource
    Online Resource
    Science Publishing Corporation ; 2018
    In:  International Journal of Engineering & Technology Vol. 7, No. 3.3 ( 2018-06-08), p. 611-
    In: International Journal of Engineering & Technology, Science Publishing Corporation, Vol. 7, No. 3.3 ( 2018-06-08), p. 611-
    Abstract: The automatic railway system is a better replacement for the manual standard. The system directs to the controlling of railway gate, track switching, ticket buying and checking, train arrival recognizing and the security system enhancing in railway platform with cloud services. The entire system is automated; errors occurring due to manual operation can be prevented to minimize accidents occurring due to the indifferent and the negligent nature of the today’s world. The system employs two pair of IR sensors, one for the automatic gate control, and another for the track switching system. The IR sensors are the pivot in the detection of the arrival and departure of the train thus forming the Gate control system. The same mechanism used in the track switching unit to switch the track. The system that checks for proximity employs a KFS beacon, an on-off switch that forces the train to stop upon its presence and depart later. An electric vibrating motor is set in place to vibrate the platform upon train’s arrival and to alert the passenger who unknowingly steps over the specified limit. A rotating ultrasonic sensor embedded between the tracks, does the job of sensing a living being on the track near the platform and the gate controlling unit. Train Ticket payment and checker is initiated with Radio Frequency reader, GPS system and finger print scanning device with zero wait strategy. Therefore, the efficiently reliable system is operated automatically throughout the railway system. 
    Type of Medium: Online Resource
    ISSN: 2227-524X
    URL: Issue
    Language: Unknown
    Publisher: Science Publishing Corporation
    Publication Date: 2018
    detail.hit.zdb_id: 2661563-0
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  • 3
    In: ChemistrySelect, Wiley, Vol. 2, No. 20 ( 2017-07-11), p. 5492-5496
    Abstract: A series of regioisomeric (2,5‐dimethoxybenzoic acid, veratric acid) analogues were prepared by swapping the carboxylic motif to its oxadiazole bioisostere and have been screened for in vitro anticancer studies by using MTT (3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide) colorimetric assay. All of them were well characterized by spectroscopic techniques. Among the screened compounds, 9 i (2‐(2,5‐dimethoxyphenyl)‐5‐(5‐phenylthiophen‐2‐yl)‐1,3,4‐oxadiazole) demonstrated superior activity against MDA231 cells. Products 9 i displayed excellent activity against DU145, HCT15 and 10 i (2‐(3,4‐dimethoxyphenyl)‐5‐(5‐phenylthiophen‐2‐yl)‐1,3,4‐oxadiazole) against MDA231 cells. Structure of 10 c (2‐(3,4‐dimethoxyphenyl)‐5‐(2,4,6‐trimethoxyphenyl)‐1,3,4‐oxadiazole) was further authenticated through single crystal X‐ray diffraction. Analogue 9 i have come out to be the best anticancer and antimycobacterial agent.
    Type of Medium: Online Resource
    ISSN: 2365-6549 , 2365-6549
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2844262-3
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  • 4
    In: Journal of Genetic Engineering and Biotechnology, Springer Science and Business Media LLC, Vol. 19, No. 1 ( 2021-12)
    Abstract: Autoinflammatory disorders are the group of inherited inflammatory disorders caused due to the genetic defect in the genes that regulates innate immune systems. These have been clinically characterized based on the duration and occurrence of unprovoked fever, skin rash, and patient’s ancestry. There are several autoinflammatory disorders that are found to be prevalent in a specific population and whose disease genetic epidemiology within the population has been well understood. However, India has a limited number of genetic studies reported for autoinflammatory disorders till date. The whole genome sequencing and analysis of 1029 Indian individuals performed under the IndiGen project persuaded us to perform the genetic epidemiology of the autoinflammatory disorders in India. Results We have systematically annotated the genetic variants of 56 genes implicated in autoinflammatory disorder. These genetic variants were reclassified into five categories (i.e., pathogenic, likely pathogenic, benign, likely benign, and variant of uncertain significance (VUS)) according to the American College of Medical Genetics and Association of Molecular pathology (ACMG-AMP) guidelines. Our analysis revealed 20 pathogenic and likely pathogenic variants with significant differences in the allele frequency compared with the global population. We also found six causal founder variants in the IndiGen dataset belonging to different ancestry. We have performed haplotype prediction analysis for founder mutations haplotype that reveals the admixture of the South Asian population with other populations. The cumulative carrier frequency of the autoinflammatory disorder in India was found to be 3.5% which is much higher than reported. Conclusion With such frequency in the Indian population, there is a great need for awareness among clinicians as well as the general public regarding the autoinflammatory disorder. To the best of our knowledge, this is the first and most comprehensive population scale genetic epidemiological study being reported from India.
    Type of Medium: Online Resource
    ISSN: 2090-5920
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2637420-1
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  • 5
    In: Synthesis, Georg Thieme Verlag KG, Vol. 54, No. 16 ( 2022-08), p. 3623-3630
    Abstract: An effective synthetic approach has been demonstrated for the construction of diverse bicyclic fused cyclopentenones from Morita–Baylis–Hillman (MBH) carbonates of propiolaldehydes. The present transformation was initiated through the propargylation of an alkenylamine with an MBH carbonate followed by the Pauson–Khand reaction of the product methyl 3-(alkenylamino)-2-methylenealk-4-ynoate. This facile method provides diverse scaffolds of cyclopentenone fused with aza-cycles having additional functionality in good yields.
    Type of Medium: Online Resource
    ISSN: 0039-7881 , 1437-210X
    RVK:
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2022
    detail.hit.zdb_id: 204080-3
    detail.hit.zdb_id: 2033062-5
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  • 6
    In: Pharmacogenomics, Future Medicine Ltd, Vol. 22, No. 10 ( 2021-07), p. 603-618
    Abstract: Aim: Numerous drugs are being widely prescribed for COVID-19 treatment without any direct evidence for the drug safety/efficacy in patients across diverse ethnic populations. Materials & methods: We analyzed whole genomes of 1029 Indian individuals (IndiGen) to understand the extent of drug–gene (pharmacogenetic), drug–drug and drug–drug–gene interactions associated with COVID-19 therapy in the Indian population. Results: We identified 30 clinically significant pharmacogenetic variants and 73 predicted deleterious pharmacogenetic variants. COVID-19-associated pharmacogenes were substantially overlapped with those of metabolic disorder therapeutics. CYP3A4, ABCB1 and ALB are the most shared pharmacogenes. Fifteen COVID-19 therapeutics were predicted as likely drug–drug interaction candidates when used with four CYP inhibitor drugs. Conclusion: Our findings provide actionable insights for future validation studies and improved clinical decisions for COVID-19 therapy in Indians.
    Type of Medium: Online Resource
    ISSN: 1462-2416 , 1744-8042
    Language: English
    Publisher: Future Medicine Ltd
    Publication Date: 2021
    SSG: 15,3
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  • 7
    Online Resource
    Online Resource
    Elsevier BV ; 2019
    In:  Physica B: Condensed Matter Vol. 556 ( 2019-03), p. 97-102
    In: Physica B: Condensed Matter, Elsevier BV, Vol. 556 ( 2019-03), p. 97-102
    Type of Medium: Online Resource
    ISSN: 0921-4526
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2019
    detail.hit.zdb_id: 392531-6
    detail.hit.zdb_id: 1466579-7
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  • 8
    Online Resource
    Online Resource
    Naturalis Biodiversity Center ; 2023
    In:  Persoonia - Molecular Phylogeny and Evolution of Fungi Vol. 50, No. 1 ( 2023-06-30), p. 158-310
    In: Persoonia - Molecular Phylogeny and Evolution of Fungi, Naturalis Biodiversity Center, Vol. 50, No. 1 ( 2023-06-30), p. 158-310
    Abstract: Novel species of fungi described in this study include those from various countries as follows: Australia , Aschersonia mackerrasiae on whitefly, Cladosporium corticola on bark of Melaleuca quinquenervia , Penicillium nudgee from soil under Melaleuca quinquenervia , Pseudocercospora blackwoodiae on leaf spot of Persoonia falcata , and Pseudocercospora dalyelliae on leaf spot of Senna alata . Bolivia , Aspicilia lutzoniana on fully submersed siliceous schist in high-mountain streams, and Niesslia parviseta on the lower part and apothecial discs of Erioderma barbellatum onatwig. Brazil , Cyathus bonsai on decaying wood, Geastrum albofibrosum from moist soil with leaf litter, Laetiporus pratigiensis on a trunk of a living unknown hardwood tree species, and Scytalidium synnematicum on dead twigs of unidentified plant. Bulgaria , Amanita abscondita on sandy soil in a plantation of Quercus suber . Canada , Penicillium acericola on dead bark of Acer saccharum , and Penicillium corticola on dead bark of Acer saccharum . China , Colletotrichum qingyuanense on fruit lesion of Capsicum annuum . Denmark , Helminthosphaeria leptospora on corticioid Neohypochnicium cremicolor. Ecuador (Galapagos) , Phaeosphaeria scalesiae on Scalesia sp. Finland , Inocybe jacobssonii on calcareouss oils in dry forests and park habitats. France , Cortinarius rufomyrrheus on sandy soil under Pinus pinaster , and Periconia neominutissima on leaves of Poaceae . India , Coprinopsis fragilis on decaying bark of logs, Filoboletus keralensis on unidentified woody substrate, Penicillium sankaranii from soil, Physisporinus tamilnaduensis on the trunk of Azadirachta indica , and Poronia nagaraholensis on elephant dung. Iran , Neosetophoma fic on infected leaves of Ficus elastica . Israel , Cnidariophoma eilatica (incl. Cnidariophoma gen. nov.) from Stylophora pistillata . Italy , Lyophyllum obscurum on acidic soil. Namibia , Aureobasidium faidherbiae on dead leaf of Faidherbia albida , and Aureobasidium welwitschiae on dead leaves of Welwitschia mirabilis . Netherlands , Gaeumannomycella caricigena on dead culms of Carex elongata , Houtenomyces caricicola (incl. Houtenomyces gen. nov.) on culms of Carex disticha , Neodacampia ulmea (incl. Neodacampia gen. nov.) on branch of Ulmus laevis , Niesslia phragmiticola on dead standing culms of Phragmites australis , Pseudopyricularia caricicola on culms of Carex disticha , and Rhodoveronaea nieuwwulvenica on dead bamboo sticks. Norway , Arrhenia similis half-buried and moss-covered pieces of rotting wood in grass-grownpath. Pakistan , Mallocybe ahmadii on soil. Poland , Beskidomyces laricis (incl. Beskidomyces gen. nov.) from resin of Larix decidua ssp. polonica , Lapidomyces epipinicola from sooty mould community on Pinus nigra , and Leptographium granulatum from a gallery of Dendroctonus micans on Picea abies . Portugal , Geoglossum azoricum on mossy areas of laurel forest areas planted with Cryptomeria japonica , and Lunasporangiospora lusitanica from a biofilm covering a bio deteriorated limestone wall. Qatar , Alternaria halotolerans from hypersaline sea water, and Alternaria qatarensis from water sample collected from hypersaline lagoon. South Africa , Alfaria thamnochorti on culm of Thamnochortus fraternus , Knufia aloeicola on Aloe gariepensis , Muriseptatomyces restionacearum (incl. Muriseptatomyces gen. nov.) on culms of Restionaceae , Neocladosporium arctotis on nest of cases of bagworm moths( Lepidoptera, Psychidae ) on Arctotis auriculata , Neodevriesia scadoxi on leaves of Scadoxus puniceus , Paraloratospora schoenoplecti on stems of Schoenoplectus lacustris , Tulasnella epidendrea from the roots of Epidendrum × obrienianum , and Xenoidriella cinnamomi (incl. Xenoidriella gen. nov.) on leaf of Cinnamomum camphora . South Korea , Lemonniera fraxinea on decaying leaves of Fraxinus sp. frompond. Spain , Atheniella lauri on the bark of fallen trees of Laurus nobilis , Halocryptovalsa endophytica from surface-sterilised, asymptomatic roots of Salicornia patula , Inocybe amygdaliolens on soil in mixed forest, Inocybe pityusarum on calcareous soil in mixed forest, Inocybe roseobulbipes on acidic soils, Neonectria borealis from roots of Vitis berlandieri × Vitis rupestris , Sympoventuria eucalyptorum on leaves of Eucalyptus sp., and Tuber conchae fromsoil. Sweden , Inocybe bidumensis on calcareous soil. Thailand , Cordyceps sandindaengensis on Lepidoptera pupa, buried in soil, Ophiocordyceps kuchinaraiensis on Coleoptera larva, buried in soil, and Samsoniella winandae on Lepidoptera pupa, buriedinsoil. Taiwan region (China) , Neophaeosphaeria livistonae on dead leaf of Livistona rotundifolia . Türkiye , Melanogaster anatolicus on clay loamy soils. UK , Basingstokeomyces allii (incl. Basingstokeomyces gen. nov.) on leaves of Allium schoenoprasum . Ukraine , Xenosphaeropsis corni on recently dead stem of Cornus alba. USA , Nothotrichosporon aquaticum (incl. Nothotrichosporon gen. nov.) from water, and Periconia philadelphiana from swab of coil surface. Morphological and culture characteristics for these new taxa are supported by DNA barcodes.
    Type of Medium: Online Resource
    ISSN: 0031-5850
    Language: English
    Publisher: Naturalis Biodiversity Center
    Publication Date: 2023
    detail.hit.zdb_id: 2389449-0
    SSG: 12
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  • 9
    Online Resource
    Online Resource
    Level Up Business Center ; 2016
    In:  Journal of Evidence Based Medicine and Healthcare Vol. 3, No. 14 ( 2016-2-18), p. 462-467
    In: Journal of Evidence Based Medicine and Healthcare, Level Up Business Center, Vol. 3, No. 14 ( 2016-2-18), p. 462-467
    Type of Medium: Online Resource
    ISSN: 2349-2562 , 2349-2570
    Uniform Title: English
    Language: Unknown
    Publisher: Level Up Business Center
    Publication Date: 2016
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  • 10
    In: Nucleic Acids Research, Oxford University Press (OUP), ( 2020-10-23)
    Abstract: With the advent of next-generation sequencing, large-scale initiatives for mining whole genomes and exomes have been employed to better understand global or population-level genetic architecture. India encompasses more than 17% of the world population with extensive genetic diversity, but is under-represented in the global sequencing datasets. This gave us the impetus to perform and analyze the whole genome sequencing of 1029 healthy Indian individuals under the pilot phase of the ‘IndiGen’ program. We generated a compendium of 55,898,122 single allelic genetic variants from geographically distinct Indian genomes and calculated the allele frequency, allele count, allele number, along with the number of heterozygous or homozygous individuals. In the present study, these variants were systematically annotated using publicly available population databases and can be accessed through a browsable online database named as ‘IndiGenomes’ http://clingen.igib.res.in/indigen/. The IndiGenomes database will help clinicians and researchers in exploring the genetic component underlying medical conditions. Till date, this is the most comprehensive genetic variant resource for the Indian population and is made freely available for academic utility. The resource has also been accessed extensively by the worldwide community since it's launch.
    Type of Medium: Online Resource
    ISSN: 0305-1048 , 1362-4962
    RVK:
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2020
    detail.hit.zdb_id: 1472175-2
    SSG: 12
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