In:
Gynecologic and Obstetric Investigation, S. Karger AG, Vol. 66, No. 2 ( 2008), p. 84-90
Abstract:
〈 i 〉 Background/Aims: 〈 /i 〉 The aim of this study was to induce endometriosis in female rhesus macaques 〈 i 〉 (Macaca mulatta) 〈 /i 〉 for research purposes. 〈 i 〉 Methods: 〈 /i 〉 Three female monkeys from 4 to 4.5 years of age underwent three consecutive attempts at endometriosis induction over an 8-month period: (i) the first attempt involved intravaginal sampling of endometrial tissue and transplantation into the intrapelvic cavity; (ii) the second entailed surgical removal of endometrium after hysterotomy and intra-abdominal placement, and (iii) the third used endometrial mucosa obtained by scraping the uterus after hysterectomy, placed in a surgical pouch created in the retrovesical space (Retzius). In each case, the pelvic cavity was closely inspected after 7, 9, and 6 weeks respectively for the presence of endometriotic lesions, and peritoneal biopsies were performed. 〈 i 〉 Results: 〈 /i 〉 Neither macroscopic observation nor histological analysis revealed any endometriotic lesions. 〈 i 〉 Conclusion: 〈 /i 〉 This failure to induce endometriosis in female rhesus macaques suggests that this species is not the most efficient experimental model among primates to investigate endometriosis development or treatment.
Type of Medium:
Online Resource
ISSN:
0378-7346
,
1423-002X
Language:
English
Publisher:
S. Karger AG
Publication Date:
2008
detail.hit.zdb_id:
1482695-1
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