In:
The Clinical Journal of Pain, Ovid Technologies (Wolters Kluwer Health), Vol. 32, No. 6 ( 2016-06), p. 541-554
Abstract:
Conditioned pain modulation (CPM) responses may be affected by psychological factors such as anxiety, depression, and pain catastrophizing; however, most studies on CPM do not address these relations as their primary outcome. The aim of this meta-analysis was to analyze the findings regarding the associations between CPM responses and psychological factors in both pain-free individuals and pain patients. Materials and Methods: After a comprehensive PubMed search, 37 articles were found to be suitable for inclusion. Analyses used DerSimonian and Laird’s random-effects model on Fisher’s z-transforms of correlations; potential publication bias was tested using funnel plots and Egger’s regression test for funnel plot asymmetry. Six meta-analyses were performed examining the correlations between anxiety, depression, and pain catastrophizing, and CPM responses in healthy individuals and pain patients. Results: No significant correlations between CPM responses and any of the examined psychological factors were found. However, a secondary analysis, comparing modality-specific CPM responses and psychological factors in healthy individuals, revealed the following: (1) pressure-based CPM responses were correlated with anxiety (grand mean correlation in original units r =−0.1087; 95% confidence limits, –0.1752 to −0.0411); (2) heat-based CPM was correlated with depression ( r =0.2443; 95% confidence limits, 0.0150 to 0.4492); and (3) electrical-based CPM was correlated with pain catastrophizing levels ( r =−0.1501; 95% confidence limits, −0.2403 to −0.0574). Discussion: Certain psychological factors seem to be associated with modality-specific CPM responses in healthy individuals. This potentially supports the notion that CPM paradigms evoked by different stimulation modalities represent different underlying mechanisms.
Type of Medium:
Online Resource
ISSN:
0749-8047
DOI:
10.1097/AJP.0000000000000296
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2016
detail.hit.zdb_id:
1497640-7
Permalink