In:
Molecular Nutrition & Food Research, Wiley, Vol. 58, No. 4 ( 2014-04), p. 749-759
Abstract:
In the present study, we evaluated the anti‐inflammatory properties of several plant lignans most commonly distributed in foods. 7‐Hydroxymatairesinol ( HMR ) and its major isomer 7‐hydroxymatairesinol 2 ( HMR 2), lariciresinol, secoisolariciresinol, and pinoresinol, isolated from N orway spruce knots were examined. Methods and results We investigated the anti‐inflammatory effects of lignans on tumor necrosis factor‐α‐treated human aortic endothelial cells by measuring the expression of intracellular adhesion molecule‐1 and vascular cell adhesion molecule‐1 by cell ELISA and the adhesion of U 937 monocytes to activated endothelial cells using a cell adhesion assay. Among the lignans studied, HMR and HMR 2 significantly reduced intracellular adhesion molecule‐1 and vascular cell adhesion molecule‐1 levels as well as the adhesion of U 937 to endothelial cells. To further characterize the molecular mechanisms involved in this regulation, the effect of HMR and HMR 2 on nuclear factor‐κB, SAPK /c‐ J un NH 2‐terminal kinase and extracellular signal regulated kinase phosphorylation was assessed. Conclusion Our results demonstrated that the lignans HMR and HMR 2, dominant in cereals such as in wheat, triticale, oat, barley, millet, corn bran, and in amaranth whole grain, exhibit strong anti‐inflammatory properties in endothelial cells, at least in part, through attenuation of nuclear factor‐κ B and extracellular signal regulated kinase phosphorylation.
Type of Medium:
Online Resource
ISSN:
1613-4125
,
1613-4133
DOI:
10.1002/mnfr.201300318
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
2160372-8
SSG:
12
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