In:
Molecular Systems Biology, EMBO, Vol. 9, No. 1 ( 2013-01)
Abstract:
The stoichiometry of the human nuclear pore complex is revealed by targeted mass spectrometry and super‐resolution microscopy. The analysis reveals that the composition of the nuclear pore and other nuclear protein complexes is remodeled as a function of the cell type. image The human NPC has a previously unanticipated stoichiometry that varies across cell types. Primarily functional Nups are dynamic, while the NPC scaffold is static. Stoichiometries of many complexes are fine‐tuned toward cell type‐specific needs.
Type of Medium:
Online Resource
ISSN:
1744-4292
,
1744-4292
Language:
English
Publisher:
EMBO
Publication Date:
2013
detail.hit.zdb_id:
2193510-5
SSG:
12
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