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  • 1
    Online Resource
    Online Resource
    Drosophila Muller F Elements Maintain a Distinct Set of Genomic Properties Over 40 Million Years of Evolution
    Oxford University Press (OUP) ; 2015
    In:  G3 Genes|Genomes|Genetics Vol. 5, No. 5 ( 2015-05-01), p. 719-740
    Details
    In: G3 Genes|Genomes|Genetics, Oxford University Press (OUP), Vol. 5, No. 5 ( 2015-05-01), p. 719-740
    Abstract: The Muller F element (4.2 Mb, ~80 protein-coding genes) is an unusual autosome of Drosophila melanogaster; it is mostly heterochromatic with a low recombination rate. To investigate how these properties impact the evolution of repeats and genes, we manually improved the sequence and annotated the genes on the D. erecta, D. mojavensis, and D. grimshawi F elements and euchromatic domains from the Muller D element. We find that F elements have greater transposon density (25–50%) than euchromatic reference regions (3–11%). Among the F elements, D. grimshawi has the lowest transposon density (particularly DINE-1: 2% vs. 11–27%). F element genes have larger coding spans, more coding exons, larger introns, and lower codon bias. Comparison of the Effective Number of Codons with the Codon Adaptation Index shows that, in contrast to the other species, codon bias in D. grimshawi F element genes can be attributed primarily to selection instead of mutational biases, suggesting that density and types of transposons affect the degree of local heterochromatin formation. F element genes have lower estimated DNA melting temperatures than D element genes, potentially facilitating transcription through heterochromatin. Most F element genes (~90%) have remained on that element, but the F element has smaller syntenic blocks than genome averages (3.4–3.6 vs. 8.4–8.8 genes per block), indicating greater rates of inversion despite lower rates of recombination. Overall, the F element has maintained characteristics that are distinct from other autosomes in the Drosophila lineage, illuminating the constraints imposed by a heterochromatic milieu.
    Type of Medium: Online Resource
    ISSN: 2160-1836
    URL: Article
    DOI: 10.1534/g3.114.015966
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2015
    detail.hit.zdb_id: 2629978-1
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  • 2
    Online Resource
    Online Resource
    Development of a Definition of Postacute Sequelae of SARS-CoV-2 Infection
    American Medical Association (AMA) ; 2023
    In:  JAMA Vol. 329, No. 22 ( 2023-06-13), p. 1934-
    Details
    In: JAMA, American Medical Association (AMA), Vol. 329, No. 22 ( 2023-06-13), p. 1934-
    Abstract: SARS-CoV-2 infection is associated with persistent, relapsing, or new symptoms or other health effects occurring after acute infection, termed postacute sequelae of SARS-CoV-2 infection (PASC), also known as long COVID . Characterizing PASC requires analysis of prospectively and uniformly collected data from diverse uninfected and infected individuals. Objective To develop a definition of PASC using self-reported symptoms and describe PASC frequencies across cohorts, vaccination status, and number of infections. Design, Setting, and Participants Prospective observational cohort study of adults with and without SARS-CoV-2 infection at 85 enrolling sites (hospitals, health centers, community organizations) located in 33 states plus Washington, DC, and Puerto Rico. Participants who were enrolled in the RECOVER adult cohort before April 10, 2023, completed a symptom survey 6 months or more after acute symptom onset or test date. Selection included population-based, volunteer, and convenience sampling. Exposure SARS-CoV-2 infection. Main Outcomes and Measures PASC and 44 participant-reported symptoms (with severity thresholds). Results A total of 9764 participants (89% SARS-CoV-2 infected; 71% female; 16% Hispanic/Latino; 15% non-Hispanic Black; median age, 47 years [IQR, 35-60]) met selection criteria. Adjusted odds ratios were 1.5 or greater (infected vs uninfected participants) for 37 symptoms. Symptoms contributing to PASC score included postexertional malaise, fatigue, brain fog, dizziness, gastrointestinal symptoms, palpitations, changes in sexual desire or capacity, loss of or change in smell or taste, thirst, chronic cough, chest pain, and abnormal movements. Among 2231 participants first infected on or after December 1, 2021, and enrolled within 30 days of infection, 224 (10% [95% CI, 8.8%-11%] ) were PASC positive at 6 months. Conclusions and Relevance A definition of PASC was developed based on symptoms in a prospective cohort study. As a first step to providing a framework for other investigations, iterative refinement that further incorporates other clinical features is needed to support actionable definitions of PASC.
    Type of Medium: Online Resource
    ISSN: 0098-7484
    URL: Article
    DOI: 10.1001/jama.2023.8823
    RVK:
    XA 10000
    Language: English
    Publisher: American Medical Association (AMA)
    Publication Date: 2023
    detail.hit.zdb_id: 2958-0
    detail.hit.zdb_id: 2018410-4
    SSG: 5,21
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  • 3
    Online Resource
    Online Resource
    New‐onset diabetes after pediatric heart transplantation: A review of the Pediatric Heart Transplant Study
    Wiley ; 2019
    In:  Pediatric Transplantation Vol. 23, No. 5 ( 2019-08)
    Details
    In: Pediatric Transplantation, Wiley, Vol. 23, No. 5 ( 2019-08)
    Abstract: NDT is a well‐defined complication after solid organ transplantation. Little has been published describing the incidence, risk factors, and effect on outcome after pediatric heart transplantation. We performed a retrospective evaluation of pediatric patients from the PHTS registry from 2004 to 2014. Group comparison, associated factors, incidence using Kaplan‐Meier method, and risk factor and outcome analysis for NDT at 1 year post‐transplant. Of the 2185 recipients, 1756 were alive and followed at 1 year. Overall freedom from NDT was 98.9%, 94.7%, and 92.6% at 1, 5, and 10 years, respectively. Patients with NDT were more likely to be black (non‐Hispanic; P  = 0.002), older at time of transplant ( P   〈  0.0001), and have a higher BMI percentile at time of transplant ( P   〈  0.0001). Adjusted risk factors for NDT at 1 year were older age at transplant (years; 〉 12 years, OR: 8.8 and 5‐12 years, HR: 8.0), obese BMI percentile at time of transplant (OR: 3.8), and steroid use at 30 days after transplant (OR: 4.7). Though uncommon, NDT occurs with a constant hazard after pediatric heart transplant; it occurs more often in older patients at transplant, those who are of black race, those who are obese, and those who use steroids. Therefore, targeted weight reduction and selective steroid use in at‐risk populations could reduce the incidence of early NDT. Further data are needed to determine the risk imparted by transplantation, factors that predict late‐onset NDT, and whether NDT alters the outcome after transplant.
    Type of Medium: Online Resource
    ISSN: 1397-3142 , 1399-3046
    URL: Issue
    URL: Article
    DOI: 10.1111/petr.2019.23.issue-5
    DOI: 10.1111/petr.13476
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2008614-3
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  • 4
    Online Resource
    Online Resource
    Square Peg, Round Hole. Ventricular Assist Devices in Single Ventricles. How do We Get it Right?
    Ovid Technologies (Wolters Kluwer Health) ; 2020
    In:  ASAIO Journal Vol. 66, No. 2 ( 2020-02), p. 212-213
    Details
    In: ASAIO Journal, Ovid Technologies (Wolters Kluwer Health), Vol. 66, No. 2 ( 2020-02), p. 212-213
    Type of Medium: Online Resource
    ISSN: 1058-2916
    URL: Article
    DOI: 10.1097/MAT.0000000000001127
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2020
    detail.hit.zdb_id: 2083312-X
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  • 5
    Online Resource
    Online Resource
    Abstract 13291: Impact of VAD Support Duration on Pediatric Heart Transplant Outcomes
    Ovid Technologies (Wolters Kluwer Health) ; 2020
    In:  Circulation Vol. 142, No. Suppl_3 ( 2020-11-17)
    Details
    In: Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 142, No. Suppl_3 ( 2020-11-17)
    Abstract: Introduction: There is wide variability in the timing of heart transplant (HT) listing and consideration of organ offers after ventricular assist device (VAD) implant in children. While some centers wait weeks or months before proceeding with HT, others accept donor hearts within days of VAD surgery. We sought to determine if HT within 30 days of VAD implant impacts post-HT outcomes when compared to HT after ≥30 days of VAD support. Methods: Patients on VAD support prior to HT were extracted from the Pediatric Heart Transplant Study database. The primary endpoints were post-HT length of hospital stay (LOS) and one-year survival. Confounding was addressed by propensity score weighting using inverse probability of treatment. Propensity scores were calculated based on age at VAD implant, blood type, primary cardiac diagnosis, decade, VAD type, and allosensitization status. Group balance was verified with standardized differences. Results: A total of 1138 children underwent VAD implant prior to HT between 2000-2019 (Table 1). Most underwent HT ≥30 days after VAD (71%). The majority (70%) had an LVAD alone. Infants accounted for 22% of both groups, while those 1-11 years were 46% of the ≥30-day group and patients ≥12 years made up 42% of 〈 30-day group (p=0.001). There was no difference in the prevalence of congenital heart disease vs. cardiomyopathy (p=0.7) or high allosensitization status (p=0.8) between groups. Post-HT LOS was similar between groups (23 vs. 21 days in 〈 30 vs. ≥30 days, p=0.07). One-year survival was 90.5% in the 〈 30-day group vs. 94.5% in ≥30 days (adjusted mortality HR 1.81, 95% CI 1.15-2.86, p=0.01). Conclusions: In this large study of children undergoing HT after VAD, we found lower one-year survival in patients on VAD support for 〈 30 days prior to HT compared to those on VAD for ≥30 days before HT. These findings suggest that a strategy of delayed HT listing following VAD implant may favorably impact post-HT survival in the pediatric population.
    Type of Medium: Online Resource
    ISSN: 0009-7322 , 1524-4539
    URL: Article
    DOI: 10.1161/circ.142.suppl_3.13291
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2020
    detail.hit.zdb_id: 1466401-X
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  • 6
    Online Resource
    Online Resource
    Pediatric heart transplantation: Year in review 2020
    Elsevier BV ; 2021
    In:  The Journal of Thoracic and Cardiovascular Surgery Vol. 162, No. 2 ( 2021-08), p. 418-421
    Details
    In: The Journal of Thoracic and Cardiovascular Surgery, Elsevier BV, Vol. 162, No. 2 ( 2021-08), p. 418-421
    Type of Medium: Online Resource
    ISSN: 0022-5223
    URL: Article
    DOI: 10.1016/j.jtcvs.2021.04.073
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2021
    detail.hit.zdb_id: 2007600-9
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  • 7
    Online Resource
    Online Resource
    Preference on Cash-Choice Task Predicts Externalizing Outcomes in 17-Year-Olds
    Springer Science and Business Media LLC ; 2014
    In:  Behavior Genetics Vol. 44, No. 2 ( 2014-3), p. 102-112
    Details
    In: Behavior Genetics, Springer Science and Business Media LLC, Vol. 44, No. 2 ( 2014-3), p. 102-112
    Type of Medium: Online Resource
    ISSN: 0001-8244 , 1573-3297
    URL: Article
    DOI: 10.1007/s10519-013-9638-2
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2014
    detail.hit.zdb_id: 2014974-8
    SSG: 12
    SSG: 5,2
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  • 8
    Online Resource
    Online Resource
    Murine Hepatitis Virus Nonstructural Protein 4 Regulates Virus-Induced Membrane Modifications and Replication Complex Function
    American Society for Microbiology ; 2010
    In:  Journal of Virology Vol. 84, No. 1 ( 2010-01), p. 280-290
    Details
    In: Journal of Virology, American Society for Microbiology, Vol. 84, No. 1 ( 2010-01), p. 280-290
    Abstract: Positive-strand RNA viruses induce modifications of cytoplasmic membranes to form replication complexes. For coronaviruses, replicase nonstructural protein 4 (nsp4) has been proposed to function in the formation and organization of replication complexes. Murine hepatitis virus (MHV) nsp4 is glycosylated at residues Asn176 (N176) and N237 during plasmid expression of nsp4 in cells. To test if MHV nsp4 residues N176 and N237 are glycosylated during virus replication and to determine the effects of N176 and N237 on nsp4 function and MHV replication, alanine substitutions of nsp4 N176, N237, or both were engineered into the MHV-A59 genome. The N176A, N237A, and N176A/N237A mutant viruses were viable, and N176 and N237 were glycosylated during infection of wild-type (wt) and mutant viruses. The nsp4 glycosylation mutants exhibited impaired virus growth and RNA synthesis, with the N237A and N176A/N237A mutant viruses demonstrating more profound defects in virus growth and RNA synthesis. Electron microscopic analysis of ultrastructure from infected cells demonstrated that the nsp4 mutants had aberrant morphology of virus-induced double-membrane vesicles (DMVs) compared to those infected with wt virus. The degree of altered DMV morphology directly correlated with the extent of impairment in viral RNA synthesis and virus growth of the nsp4 mutant viruses. The results indicate that nsp4 plays a critical role in the organization and stability of DMVs. The results also support the conclusion that the structure of DMVs is essential for efficient RNA synthesis and optimal replication of coronaviruses.
    Type of Medium: Online Resource
    ISSN: 0022-538X , 1098-5514
    URL: Article
    DOI: 10.1128/JVI.01772-09
    Language: English
    Publisher: American Society for Microbiology
    Publication Date: 2010
    detail.hit.zdb_id: 1495529-5
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  • 9
    Online Resource
    Online Resource
    Project-Level Highway Management Model for Secondary Highways in Saskatchewan, Canada
    SAGE Publications ; 2003
    In:  Transportation Research Record: Journal of the Transportation Research Board Vol. 1819, No. 1 ( 2003-01), p. 297-304
    Details
    In: Transportation Research Record: Journal of the Transportation Research Board, SAGE Publications, Vol. 1819, No. 1 ( 2003-01), p. 297-304
    Abstract: Saskatchewan Highways and Transportation (SHT) is responsible for 26,000 km of primary and secondary highways in the province. The primary system was structurally built to handle high traffic volumes and heavily loaded trucks; the secondary system was constructed to provide links into the primary system for traffic volumes lower than 500 vehicles per day with few heavily loaded trucks. Secondary highways consist mostly of thin membrane surface (TMS) highways, which are oil-treated surfaces over a nonstructural roadbed. In the past few years increased heavy-truck traffic associated with rail line abandonment, elevator closures, and increased truck haul associated with economic development has deteriorated TMS highways. Years of increasing pressures and inadequate funding have forced SHT to develop and implement cost-effective, sustainable methods to manage and preserve them. A new strategy to structurally strengthen the system is a cementitious blend of material called TerraCem. Along with conventional strengthening strategies, this new method is being used throughout Saskatchewan; however, its long-term performance is unknown. Because SHT must make good decisions and should be able to demonstrate they are good, a project-level framework capable of evaluating secondary road management strategies on the basis of whole life-cycle road agency and road user costs, has been developed. The framework determines the lowest-cost strategy (agency and road user) and employs probabilistic modeling to quantify the long-term performance of the TerraCem strategy. The developed framework was applied for a project-level sample.
    Type of Medium: Online Resource
    ISSN: 0361-1981 , 2169-4052
    URL: Article
    DOI: 10.3141/1819a-43
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2003
    detail.hit.zdb_id: 2403378-9
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  • 10
    Online Resource
    Online Resource
    Atypical Mycobacterial Infection in Sequestrated Lung in an Infant Presenting with Chronic Pneumonitis and Recurrent Wheezing
    Computers, Materials and Continua (Tech Science Press) ; 2008
    In:  Congenital Heart Disease Vol. 3, No. 4 ( 2008-07), p. 284-287
    Details
    In: Congenital Heart Disease, Computers, Materials and Continua (Tech Science Press), Vol. 3, No. 4 ( 2008-07), p. 284-287
    Type of Medium: Online Resource
    ISSN: 1747-079X , 1747-0803
    URL: Issue
    URL: Article
    DOI: 10.1111/chd.2008.3.issue-4
    DOI: 10.1111/j.1747-0803.2008.00182.x
    Language: English
    Publisher: Computers, Materials and Continua (Tech Science Press)
    Publication Date: 2008
    detail.hit.zdb_id: 2231467-2
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