In:
Skin Pharmacology and Physiology, S. Karger AG, Vol. 28, No. 1 ( 2015), p. 22-30
Abstract:
〈 b 〉 〈 i 〉 Aim: 〈 /i 〉 〈 /b 〉 The purpose of this study was to characterise C 〈 sub 〉 60 〈 /sub 〉 -poly(vinylpyrrolidone) (PVP) dispersions, to analyse the cutaneous absorption of fullerenes as well as to evaluate whether UVA radiation (UVA-R) could modify its permeation profile. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Dispersions were characterised according to their pH, particle size, zeta potential, and morphology. Skin absorption studies were performed using porcine or human skin under UVA or sham irradiation. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 The C 〈 sub 〉 60 〈 /sub 〉 aggregate size was 129 ± 54 nm (as determined by nanoparticle tracking analysis) and the zeta potential was -4.93 ± 1.72 mV. The C 〈 sub 〉 60 〈 /sub 〉 aggregates presented an irregular shape (as measured by transmission electron microscopy) and permeated through human and porcine skin. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 C 〈 sub 〉 60 〈 /sub 〉 -PVP aggregates were adequately characterised. Human skin was less permeable than porcine skin, and the presence of UVA-R increased the C 〈 sub 〉 60 〈 /sub 〉 content up to the dermis.
Type of Medium:
Online Resource
ISSN:
1660-5527
,
1660-5535
Language:
English
Publisher:
S. Karger AG
Publication Date:
2015
detail.hit.zdb_id:
1483572-1
SSG:
15,3
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