In:
European Journal of Organic Chemistry, Wiley
Abstract:
5‐Halo‐1,2,3‐triazoles are important scaffolds in organic chemistry, but current click reactions cannot produce 1,4,5‐trisubstituted 5‐chloro‐1,2,3‐triazoles in a simple way. Herein, we disclosed a Cu(I)‐catalyzed interrupted click reaction, using N ‐chlorophthalimide as an electrophilic chlorine source, enabling the facile synthesis of 1,4,5‐trisubstituted 5‐chloro‐1,2,3‐triazoles in one step from readily available terminal alkynes and azides. Complete control of regioselectivities with a broad substrate scope was accomplished by this approach. Furthermore, a novel epoxidation was developed using 5‐chloro‐triazole as substrate, which could be further applied in various organic transformations.
Type of Medium:
Online Resource
ISSN:
1434-193X
,
1099-0690
DOI:
10.1002/ejoc.202300505
Language:
English
Publisher:
Wiley
Publication Date:
2023
detail.hit.zdb_id:
1475010-7
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