In:
International Journal of Cancer, Wiley, Vol. 146, No. 8 ( 2020-04-15), p. 2147-2155
Abstract:
What's new? Despite the identification of several ovarian cancer (OC) predisposition genes, familial OC risk largely remains unexplained. Here, the authors report the discovery of two new putative OC predisposition genes based on germline whole‐exome sequencing of 140 families with a strong OC family history but without known BRCA1/2 mutations. By comparing another 381 OC cases with more than 27,000 population controls, they show that the putative tumor suppressor ANKRD11 and POLE, an enzyme involved in DNA repair and replication, moderately increase OC risk. These genes may shed light on cancer etiology and improve ascertainment power of individuals at high OC risk.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2020
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
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