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  • 1
    Online Resource
    Online Resource
    JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortality
    American Association for the Advancement of Science (AAAS) ; 2021
    In:  Science Advances Vol. 7, No. 1 ( 2021-01)
    Details
    In: Science Advances, American Association for the Advancement of Science (AAAS), Vol. 7, No. 1 ( 2021-01)
    Abstract: Using AI, we identified baricitinib as having antiviral and anticytokine efficacy. We now show a 71% (95% CI 0.15 to 0.58) mortality benefit in 83 patients with moderate-severe SARS-CoV-2 pneumonia with few drug-induced adverse events, including a large elderly cohort (median age, 81 years). An additional 48 cases with mild-moderate pneumonia recovered uneventfully. Using organotypic 3D cultures of primary human liver cells, we demonstrate that interferon-α2 increases ACE2 expression and SARS-CoV-2 infectivity in parenchymal cells by greater than fivefold. RNA-seq reveals gene response signatures associated with platelet activation, fully inhibited by baricitinib. Using viral load quantifications and superresolution microscopy, we found that baricitinib exerts activity rapidly through the inhibition of host proteins (numb-associated kinases), uniquely among antivirals. This reveals mechanistic actions of a Janus kinase-1/2 inhibitor targeting viral entry, replication, and the cytokine storm and is associated with beneficial outcomes including in severely ill elderly patients, data that incentivize further randomized controlled trials.
    Type of Medium: Online Resource
    ISSN: 2375-2548
    URL: Article
    DOI: 10.1126/sciadv.abe4724
    Language: English
    Publisher: American Association for the Advancement of Science (AAAS)
    Publication Date: 2021
    detail.hit.zdb_id: 2810933-8
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  • 2
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    Online Resource
    Nicht elektive thoraxchirurgische Operationen bei Patienten mit respiratorischer Insuffizienz und Einsatz einer venovenösen extrakorporalen Membranoxygenierung
    Georg Thieme Verlag KG ; 2019
    In:  Zentralblatt für Chirurgie - Zeitschrift für Allgemeine, Viszeral-, Thorax- und Gefäßchirurgie Vol. 144, No. 01 ( 2019-02), p. 93-99
    Details
    In: Zentralblatt für Chirurgie - Zeitschrift für Allgemeine, Viszeral-, Thorax- und Gefäßchirurgie, Georg Thieme Verlag KG, Vol. 144, No. 01 ( 2019-02), p. 93-99
    Abstract: Hintergrund Patienten mit schwerer respiratorischer Insuffizienz und venovenöser extrakorporaler Membranoxygenierung (vv-ECMO) benötigen häufig eine diagnostische oder therapeutische thoraxchirurgische Intervention. Material und Methode Retrospektive Analyse von prospektiv erhobenen Daten (Regensburger ECMO-Register) aller Patienten im Zeitraum von Dezember 2010 bis Dezember 2016, die aufgrund eines akuten Lungenversagens (ALV) mit einer vv-ECMO behandelt wurden und bei denen eine diagnostische oder therapeutische thoraxchirurgische Operation (TCH-OP) durchgeführt wurde. Endpunkte waren die Indikation zur TCH-OP sowie die postoperative Morbidität und Letalität. Ergebnis Es wurden 418 Patienten (m = 285, 68%; mittleres Alter 50,0 ± 16,5 Jahre) mit einer vv-ECMO behandelt. Die häufigsten Indikationen zur vv-ECMO waren ein ALV bei Pneumonie (59,8%), postoperativ (18,7%), posttraumatisch (9,8%), nach Chemotherapie (2,8%) oder sonstigen Gründen (8,9%). Insgesamt wurden 102 (24,4%) Patienten unter vv-ECMO operiert, davon 29 Patienten (28,4%) thoraxchirurgisch. Die häufigste primäre Indikation für eine TCH-OP war therapeutisch bei Hämatothorax (n = 13; 44,8%), gefolgt von karnifizierender Pneumonie/Lungenabszess (n = 5; 17,2%), Pleuraempyem (n = 3; 10,3%) und sonstigen Ursachen (n = 3; 10,3%). Bei interstitieller Lungenerkrankung unklarer Genese (n = 5; 17,2%) erfolgte eine diagnostische Lungenbiopsie. Bei den Ersteingriffen wurde bei 27 Patienten eine Thorakotomie (93,1%), seltener eine VATS (n = 2; 6,9%) durchgeführt. Mindestens eine Rethorakotomie erfolgte in 15 Patienten (51,7%) und 9 Patienten (31,0%) wurden mehr als 2 × operiert. Die Letalität im Krankenhaus der Patienten mit TCH-OP (44,8%) war höher als die der Patienten ohne TCH-OP (35,7%; p = 0,326). Schlussfolgerung Die Indikationen für eine thoraxchirurgische Operation bei Patienten mit vv-ECMO sollten streng gestellt werden, da häufig postoperative Komplikationen mit einer hohen Reoperationsrate (58,6%) auftreten. Daher sollte eine ECMO-Therapie nur in spezialisierten Zentren mit thoraxchirurgischer Expertise erfolgen.
    Type of Medium: Online Resource
    ISSN: 0044-409X , 1438-9592
    URL: Article
    DOI: 10.1055/a-0721-1983
    Language: German
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2019
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  • 3
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    Online Resource
    Effects of electrostimulation therapy in facial nerve palsy
    Georg Thieme Verlag KG ; 2021
    In:  Archives of Plastic Surgery Vol. 48, No. 03 ( 2021-05), p. 278-281
    Details
    In: Archives of Plastic Surgery, Georg Thieme Verlag KG, Vol. 48, No. 03 ( 2021-05), p. 278-281
    Abstract: Facial palsy (FP) is a functional disorder of the facial nerve involving paralysis of the mimic muscles. According to the principle “time is muscle,” early surgical treatment is tremendously important for preserving the mimic musculature if there are no signs of nerve function recovery. In a 49-year-old female patient, even 19 months after onset of FP, successful neurotization was still possible by a V-to-VII nerve transfer and cross-face nerve grafting. Our patient suffered from complete FP after vestibular schwannoma surgery. With continuous application of electrostimulation (ES) therapy, the patient was able to bridge the period between the first onset of FP and neurotization surgery. The significance of ES for mimic musculature preservation in FP patients has not yet been fully clarified. More attention should be paid to this form of therapy in order to preserve the facial musculature, and its benefits should be evaluated in further prospective clinical studies.
    Type of Medium: Online Resource
    ISSN: 2234-6163 , 2234-6171
    URL: Article
    DOI: 10.5999/aps.2020.01025
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2021
    detail.hit.zdb_id: 2694943-X
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  • 4
    Online Resource
    Online Resource
    Thoracic Bleeding Complications in Patients With Venovenous Extracorporeal Membrane Oxygenation
    Elsevier BV ; 2018
    In:  The Annals of Thoracic Surgery Vol. 106, No. 6 ( 2018-12), p. 1668-1674
    Details
    In: The Annals of Thoracic Surgery, Elsevier BV, Vol. 106, No. 6 ( 2018-12), p. 1668-1674
    Type of Medium: Online Resource
    ISSN: 0003-4975
    URL: Article
    DOI: 10.1016/j.athoracsur.2018.07.020
    RVK:
    XA 23980
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2018
    detail.hit.zdb_id: 1499869-5
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  • 5
    Online Resource
    Online Resource
    Non-elective thoracic surgery in patients supported by veno-venous (VV) or veno-arterial (VA) extracorporeal membrane oxygenation (ECMO)
    AME Publishing Company ; 2023
    In:  Current Challenges in Thoracic Surgery Vol. 5 ( 2023-6), p. 26-26
    Details
    In: Current Challenges in Thoracic Surgery, AME Publishing Company, Vol. 5 ( 2023-6), p. 26-26
    Type of Medium: Online Resource
    ISSN: 2664-3278
    URL: Journal
    URL: Article
    DOI: 10.21037/ccts
    DOI: 10.21037/ccts-20-141
    Language: Unknown
    Publisher: AME Publishing Company
    Publication Date: 2023
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  • 6
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    Online Resource
    CCT3- LINC00326 axis regulates hepatocarcinogenic lipid metabolism
    BMJ ; 2022
    In:  Gut Vol. 71, No. 10 ( 2022-10), p. 2081-2092
    Details
    In: Gut, BMJ, Vol. 71, No. 10 ( 2022-10), p. 2081-2092
    Abstract: To better comprehend transcriptional phenotypes of cancer cells, we globally characterised RNA-binding proteins (RBPs) to identify altered RNAs, including long non-coding RNAs (lncRNAs). Design To unravel RBP-lncRNA interactions in cancer, we curated a list of ~2300 highly expressed RBPs in human cells, tested effects of RBPs and lncRNAs on patient survival in multiple cohorts, altered expression levels, integrated various sequencing, molecular and cell-based data. Results High expression of RBPs negatively affected patient survival in 21 cancer types, especially hepatocellular carcinoma (HCC). After knockdown of the top 10 upregulated RBPs and subsequent transcriptome analysis, we identified 88 differentially expressed lncRNAs, including 34 novel transcripts. CRISPRa-mediated overexpression of four lncRNAs had major effects on the HCC cell phenotype and transcriptome. Further investigation of four RBP-lncRNA pairs revealed involvement in distinct regulatory processes. The most noticeable RBP-lncRNA connection affected lipid metabolism, whereby the non-canonical RBP CCT3 regulated LINC00326 in a chaperonin-independent manner. Perturbation of the CCT3- LINC00326 regulatory network led to decreased lipid accumulation and increased lipid degradation in cellulo as well as diminished tumour growth in vivo . Conclusions We revealed that RBP gene expression is perturbed in HCC and identified that RBPs exerted additional functions beyond their tasks under normal physiological conditions, which can be stimulated or intensified via lncRNAs and affected tumour growth.
    Type of Medium: Online Resource
    ISSN: 0017-5749 , 1468-3288
    URL: Article
    DOI: 10.1136/gutjnl-2021-325109
    RVK:
    XA 10000
    Language: English
    Publisher: BMJ
    Publication Date: 2022
    detail.hit.zdb_id: 1492637-4
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  • 7
    Online Resource
    Online Resource
    Modified Borggreve–Van Nes-Winkelmann rotationplasty for surgery in developing countries
    Springer Science and Business Media LLC ; 2022
    In:  BMC Surgery Vol. 22, No. 1 ( 2022-09-07)
    Details
    In: BMC Surgery, Springer Science and Business Media LLC, Vol. 22, No. 1 ( 2022-09-07)
    Abstract: Amputation is still the most common therapy for patients suffering from osteosarcoma in Myanmar, despite the fact that limb salvage surgery e.g. Borggreve–Van Nes-Winkelmann rotationplasty for malignant tumors located within the distal femur or proximal tibia is the current state-of-the-art reconstructive procedure. A safe and reliable operation technique is crucial in order to perform a complex surgical procedure like the rotationplasty in lower-middle income economies with limited infrastructure and resources. The authors present seven cases of patients with osteosarcomas that received a Borggreve–Van Nes-Winkelmann rotationplasty with an evaluation of the procedures focusing on safety and sustainability. Methods From 2019 until 2020, seven young patients with osteosarcomas of the distal femur or proximal tibia were treated with Borggreve–Van Nes-Winkelmann rotationplasties in the Orthopaedic Hospital in Mandalay, Myanmar. As modification of the standard procedure the dissection and subsequent clamping of the femoral artery in order to minimize blood loss as well as the formation of an adipocutaneous flap that minimizes swelling and decreases the pressure on the vessels were successfully performed. This modified procedure resembles a safe and simplified surgical technique that is feasible under the circumstances of lower-middle income economies with good outcomes. Results All patients showed good functional and aesthetic results. One of the seven patients needed secondary wound closure due to wound dehiscence. Conclusions A simplified and safe operation technique for the performance of the Van Nes-Borggreve rotationplasty was adapted to the given constraints in lower-middle income economies and proved to be successful. Trial registration All patients approved to participate in the study and have given consent to publication.
    Type of Medium: Online Resource
    ISSN: 1471-2482
    URL: Article
    DOI: 10.1186/s12893-022-01780-z
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2050442-1
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  • 8
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    Online Resource
    The influence of pulsed electromagnetic field therapy (PEMFT) on cutaneous blood flow in healthy volunteers
    IOS Press ; 2021
    In:  Clinical Hemorheology and Microcirculation Vol. 76, No. 4 ( 2021-01-11), p. 495-501
    Details
    In: Clinical Hemorheology and Microcirculation, IOS Press, Vol. 76, No. 4 ( 2021-01-11), p. 495-501
    Abstract: BACKGROUND: The biophysical interaction induced by low energy pulsed electromagnetic field therapy (PEMFT) on the capillary microcirculation is not well understood. Several studies indicate a significant effect of PEMFT in patients with chronic medical conditions. OBJECTIVE: The aim of this study was to evaluate the influence of PEMFT on skin microcirculation in healthy volunteers. METHODS: 15 healthy participants were included. Nine PEMF treatments were applied over three weeks in an 48-hour interval. The PEMFT system (BEMER) was placed beneath one of the participants’ leg with the contralateral side serving as a control. A forty-minute application period was preceded by a 10-minute resting phase. Measuring was done using two Laser Doppler probes (LEA) placed on each anterior lateral thigh. RESULTS: All outcome parameters including flow, mixed venous oxygen saturation and relative venous hemoglobin showed a significant increase during the experiment when compared to the baseline values of the resting phase in both groups (p  〈  0.01). Comparing both groups, the measurement values during the experiment did not differ (p  〉  0.05) except for higher flow values in the control group (P = 0.03). Over time, baseline values of both groups showed no significant difference (p  〉  0.05). CONCLUSION: We found a significant increase of all measurement parameters during the study compared to the baseline values with no difference between the PEMF and control group.
    Type of Medium: Online Resource
    ISSN: 1386-0291 , 1875-8622
    URL: Article
    DOI: 10.3233/CH-209224
    Language: Unknown
    Publisher: IOS Press
    Publication Date: 2021
    detail.hit.zdb_id: 2026405-7
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