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  • 1
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    P5
    Elsevier BV ; 2013
    In:  Nitric Oxide Vol. 31 ( 2013-04), p. S15-
    Details
    In: Nitric Oxide, Elsevier BV, Vol. 31 ( 2013-04), p. S15-
    Type of Medium: Online Resource
    ISSN: 1089-8603
    URL: Article
    DOI: 10.1016/j.niox.2013.02.007
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2013
    detail.hit.zdb_id: 1471433-4
    SSG: 12
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  • 2
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    New 1,4‐Dihydropyridines Down‐regulate Nitric Oxide in Animals with Streptozotocin‐induced Diabetes Mellitus and Protect Deoxyribonucleic Acid against Peroxynitrite Action
    Wiley ; 2016
    In:  Basic & Clinical Pharmacology & Toxicology Vol. 119, No. 1 ( 2016-07), p. 19-31
    Details
    In: Basic & Clinical Pharmacology & Toxicology, Wiley, Vol. 119, No. 1 ( 2016-07), p. 19-31
    Abstract: Diabetes mellitus ( DM ) and its complications cause numerous health and social problems throughout the world. Pathogenic actions of nitric oxide ( NO ) are responsible to a large extent for development of complications of DM . Search for compounds regulating NO production in patients with DM is thus important for the development of pharmacological drugs. Dihydropyridines (1,4‐ DHP s) are prospective compounds from this point of view. The goals of this study were to study the in vivo effects of new DHP s on NO and reactive nitrogen and oxygen species production in a streptozotocin ( STZ )‐induced model of DM in rats and to study their ability to protect DNA against nocive action of peroxynitrite. STZ ‐induced diabetes caused an increase in NO production in the liver, kidneys, blood and muscles, but a decrease in NO in adipose tissue of STZ ‐treated animals. Cerebrocrast treatment was followed by normalization of NO production in the liver, kidneys and blood. Two other DHP s, etaftorone and fenoftorone, were effective in decreasing NO production in kidneys, blood and muscles of diabetic animals. Furthermore, inhibitors of nitric oxide synthase ( NOS ) and an inhibitor of xanthine oxidoreductase ( XOR ) decreased NO production in kidneys of diabetic animals. Treatment with etaftorone decreased expression of inducible NOS and XOR in kidneys, whereas it increased the expression of endothelial NOS . In vitro , the studied DHP s did not significantly inhibit the activities of NOS and XOR but affected the reactivity of peroxynitrite with DNA . These new DHP s thus appear of strong interest for treatment of DM complications.
    Type of Medium: Online Resource
    ISSN: 1742-7835 , 1742-7843
    URL: Issue
    URL: Article
    DOI: 10.1111/bcpt.2016.119.issue-1
    DOI: 10.1111/bcpt.12542
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2151592-X
    SSG: 15,3
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  • 3
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    Transcriptome of GH-producing pituitary neuroendocrine tumours and models are significantly affected by somatostatin analogues
    Springer Science and Business Media LLC ; 2023
    In:  Cancer Cell International Vol. 23, No. 1 ( 2023-02-11)
    Details
    In: Cancer Cell International, Springer Science and Business Media LLC, Vol. 23, No. 1 ( 2023-02-11)
    Abstract: Pituitary neuroendocrine tumours (PitNETs) are neoplasms of the pituitary that overproduce hormones or cause unspecific symptoms due to mass effect. Growth hormone overproducing GH-producing PitNETs cause acromegaly leading to connective tissue, metabolic or oncologic disorders. The medical treatment of acromegaly is somatostatin analogues (SSA) in specific cases combined with dopamine agonists (DA), but almost half of patients display partial or full SSA resistance and potential causes of this are unknown. In this study we investigated transcriptomic landscape of GH-producing PitNETs on several levels and functional models—tumour tissue of patients with and without SSA preoperative treatment, tumour derived pituispheres and GH3 cell line incubated with SSA to study effect of medication on gene expression. MGI sequencing platform was used to sequence total RNA from PitNET tissue, pituispheres, mesenchymal stromal stem-like cells (MSC), and GH3 cell cultures, and data were analysed with Salmon—DeSeq2 pipeline. We observed that the GH-producing PitNETs have distinct changes in growth hormone related pathways related to its functional status alongside inner cell signalling, ion transport, cell adhesion and extracellular matrix characteristic patterns. In pituispheres model, treatment regimens (octreotide and cabergoline) affect specific cell proliferation ( MKI67) and core functionality pathways ( RYR2 , COL8A2 , H LA-G , ARFGAP1 , TGFBR2) . In GH3 cells we observed that medication did not have transcriptomic effects similar to preoperative treatment in PitNET tissue or pituisphere model. This study highlights the importance of correct model system selection for cell transcriptomic profiling and data interpretation that could be achieved in future by incorporating NGS methods and detailed cell omics profiling in PitNET model research.
    Type of Medium: Online Resource
    ISSN: 1475-2867
    URL: Article
    DOI: 10.1186/s12935-023-02863-4
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2091573-1
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  • 4
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    Optical Coherence Tomography Biomarkers of the Outer Blood—Retina Barrier in Patients with Diabetic Macular Oedema
    Hindawi Limited ; 2020
    In:  Journal of Diabetes Research Vol. 2020 ( 2020-10-13), p. 1-10
    Details
    In: Journal of Diabetes Research, Hindawi Limited, Vol. 2020 ( 2020-10-13), p. 1-10
    Abstract: Background. Numerous studies confirmed the main role of the inner blood-retinal barrier in the development of Diabetic Macular Oedema (DMO). Lately, the focus of research shifted towards the external retinal barrier with potential involvement in the pathogenesis of DMO. Objective. We aim to identify the OCT changes of the external blood-retinal barrier in patients with DMO and to define them as biomarkers with predictive value. Materials and method. We set up retrospectively 3 groups of patients diagnosed with nonproliferative diabetic retinopathy (NPDR) and DMO, proliferative diabetic retinopathy (PDR) and DMO, and controls. We compared the RPE thickness in every quadrant between groups and performed correlations between best-corrected visual acuity (BCVA) and the thickness of the retinal layers. The Social Science Statistics platform was used for statistical tests. Results. The NPDR-DMO group consisted of 18 eyes, the PDR-DMO group consisted of 19 eyes, and the control group included 36 eyes. In the PDR-DMO group, RPE thickness was decreased in almost all quadrants ( p 〈 0.001 ); in the NPDR-DMO group, only the central minimum and central maximum values of the RPE thickness were significantly different from the control group. We did not find any strong correlation between BCVA and the thickness of the retinal layers. Conclusion. The thickness of the RPE layer is an OCT biomarker able to predict the functioning of the outer BRB. Eyes with PDR-DMO exhibited decreased thickness of the RPE layer in almost all quadrants, highlighting the degenerative changes occurring in a hypoxic environment. The thickness of a specific layer could not be identified as a biomarker to correlate significantly with BCVA, most likely because we did not analyze specific morphologic features, such as continuity and reflectivity. The analysis of the RPE thickness could clarify the unexplained decrease of BCVA and predict early the evolution of DR.
    Type of Medium: Online Resource
    ISSN: 2314-6753 , 2314-6745
    URL: Article
    DOI: 10.1155/2020/8880586
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2711897-6
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  • 5
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    Progression of Diabetic Kidney Disease and Gastrointestinal Symptoms in Patients with Type I Diabetes
    MDPI AG ; 2023
    In:  Biomedicines Vol. 11, No. 10 ( 2023-09-29), p. 2679-
    Details
    In: Biomedicines, MDPI AG, Vol. 11, No. 10 ( 2023-09-29), p. 2679-
    Abstract: (1) Background: Little research is conducted on the link between diabetic kidney disease (DKD) progression and diabetic gastroenteropathy in type 1 diabetes (T1D). (2) Methods. We performed a cross-sectional study with 100 T1D patients; 27 of them had progressive DKD, defined as an estimated glomerular filtration rate (eGFR) decline ≥3 mL/min/year or increased albuminuria stage, over a mean follow-up time of 5.89 ± 1.73 years. A newly developed score with 17 questions on gastrointestinal (GI) symptoms was used. Faecal calprotectin was measured by ELISA. Lower GI endoscopies were performed in 21 patients. (3) Results: The gastrointestinal symptom score demonstrated high reliability (Cronbach’s α = 0.78). Patients with progressive DKD had higher GI symptom scores compared to those with stable DKD (p = 0.019). The former group demonstrated more frequent bowel movement disorders (p 〈 0.01). The scores correlated negatively with eGFR (r = −0.335; p = 0.001), positively with albuminuria (r = 0.245; p = 0.015), Hba1c (r = 0.305; p = 0.002), and diabetes duration (r = 0.251; p = 0.012). Faecal calprotectin levels did not differ between DKD groups significantly. The most commonly reported histopathological findings of enteric mucosa were infiltration with eosinophils, lymphocytes, plasmacytes, the presence of lymphoid follicles, and lymphoid aggregates. Conclusion: The progression of DKD is positively correlated with gastrointestinal symptoms; however, more research is needed to clarify the causal relationships of the gut-kidney axis in T1D.
    Type of Medium: Online Resource
    ISSN: 2227-9059
    URL: Article
    DOI: 10.3390/biomedicines11102679
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2720867-9
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  • 6
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    Impact of interval walking training managed through smart mobile devices on albuminuria and leptin/adiponectin ratio in patients with type 2 diabetes
    Wiley ; 2020
    In:  Physiological Reports Vol. 8, No. 13 ( 2020-07)
    Details
    In: Physiological Reports, Wiley, Vol. 8, No. 13 ( 2020-07)
    Type of Medium: Online Resource
    ISSN: 2051-817X , 2051-817X
    URL: Article
    DOI: 10.14814/phy2.14506
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2724325-4
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  • 7
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    Correction of glycaemia and GLUT1 level by mildronate in rat streptozotocin diabetes mellitus model
    Wiley ; 2011
    In:  Cell Biochemistry and Function Vol. 29, No. 1 ( 2011-01), p. 55-63
    Details
    In: Cell Biochemistry and Function, Wiley, Vol. 29, No. 1 ( 2011-01), p. 55-63
    Type of Medium: Online Resource
    ISSN: 0263-6484
    URL: Article
    DOI: 10.1002/cbf.1719
    Language: English
    Publisher: Wiley
    Publication Date: 2011
    detail.hit.zdb_id: 1496553-7
    SSG: 12
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  • 8
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    Association Study of Genetic Variants in the 14q11 - 14q13 Proteasomal Genes Cluster with Juvenile Idiopathic Arthritis (JIA) in Latvian Population
    Walter de Gruyter GmbH ; 2009
    In:  Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences. Vol. 63, No. 4-5 ( 2009-01-1), p. 214-221
    Details
    In: Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences., Walter de Gruyter GmbH, Vol. 63, No. 4-5 ( 2009-01-1), p. 214-221
    Abstract: The possible role of proteasomes in the development of autoimmune diseases was hypothesised after discovery of the involvement of proteasomal LMP2 and LMP7 subunits in antigene processing. The objective of this study was to determine the association between allelic variants of the genes encoding proteasomal proteins PSME1, PSME2 and PSMA6 and juvenile idiopathic arthritis (JIA) in the Latvian population. One Indel G -4543 CA -4544 →GA and four SNPs related to the PSMA6 gene (A -2486 →G and C -1910 →T, upstream promoter, C -110 →A of promoter, and C -8 →G of 5'UTR), of two cSNP in PSME1 (G 1457 →A:Val 104 , exon 6 and C 2536 →A: Lys 244 →Thr, exon 11) and in PSME2 (C 1153 →G:Arg 61 →Gly, exon 4 and A 1440 →C:His 89 →Pro, exon 6) were geno-typed by means of primer-specific PCR, CAPS assay and/or sequencing in case/control study composed from the 156 JIA patients and 214 healthy individuals. Allele frequency and genotype distribution was similar in cases and controls for Indel, and SNPs A -2486 →G, C -1910 →T and C -8 →G of PSMA6, as well as for all studied cSNPs in PSME1 and PSME2 genes. Differences in A -110 allele and CG genotype frequencies were close to the statistically significant P level in JIA patients and healthy individuals, however, when an additive model was applied, the difference in the C -110 →A locus turned out to be statistically significant. The results support the hypothesis of the possible association of PSMA6 gene allelic variants with JIA in the Latvian population.
    Type of Medium: Online Resource
    ISSN: 1407-009X
    URL: Article
    DOI: 10.2478/v10046-009-0045-2
    Language: Unknown
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2009
    detail.hit.zdb_id: 2487550-8
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  • 9
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    Quantitative and qualitative analysis of the quality of life of Type 1 diabetes patients using insulin pumps and of those receiving multiple daily insulin injections
    Springer Science and Business Media LLC ; 2022
    In:  Health and Quality of Life Outcomes Vol. 20, No. 1 ( 2022-12)
    Details
    In: Health and Quality of Life Outcomes, Springer Science and Business Media LLC, Vol. 20, No. 1 ( 2022-12)
    Abstract: Insulin pump therapy represents an alternative to multiple daily injections and can improve glycemic control and quality of life (QoL) in Type 1 diabetes mellitus (T1DM) patients. We aimed to explore the differences and factors related to the T1DM-specific QoL of such patients in Latvia. Design and methods A mixed-method cross-sectional study on 87 adult T1DM patients included 20 pump users and 67 users of injections who participated in the quantitative part of the study; 8 pump users and 13 injection users participated in the qualitative part. Patients were invited to participate using a dedicated digital platform. Their QoL and self-management habits were assessed using specially developed questionnaires adapted to Latvian conditions. Multiple logistic regression models were built to investigate the association between social and self-management factors and patients’ QoL. In addition, qualitative analysis of answers was performed. Results Insulin pump users were younger, had higher incomes, and reported higher T1DM expenses than users of multiple daily injections. There were no differences in self-management between the groups; Total QoL differed at the 0.1 significance level. In fully adjusted multiple logistic regression models, the most important factor that increased Total QoL was lower T1DM-related expenses (odds ratio, OR 7.02 [95% confidence interval 1.29; 38.0]). Men and those with more years of living with T1DM had better QoL (OR 9.62 [2.20; 42.1] and OR 1.16 [1.05; 1.29], respectively), but the method of administration was not significantly associated with QoL (OR 7.38 [0.87; 62.9] ). Qualitative data supported the results of quantitative analysis. Conclusions QoL was the main reason to use an insulin pump, while the expense was the main reason to avoid the use of it or to stop using it. Reimbursement policies thus should be considered to enable patients to choose the more convenient method for themselves.
    Type of Medium: Online Resource
    ISSN: 1477-7525
    URL: Article
    DOI: 10.1186/s12955-022-02029-2
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2098765-1
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  • 10
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    Novel susceptibility loci identified in a genome-wide association study of type 2 diabetes complications in population of Latvia
    Springer Science and Business Media LLC ; 2021
    In:  BMC Medical Genomics Vol. 14, No. 1 ( 2021-12)
    Details
    In: BMC Medical Genomics, Springer Science and Business Media LLC, Vol. 14, No. 1 ( 2021-12)
    Abstract: Type 2 diabetes complications cause a serious emotional and economical burden to patients and healthcare systems globally. Management of both acute and chronic complications of diabetes, which dramatically impair the quality of patients' life, is still an unsolved issue in diabetes care, suggesting a need for early identification of individuals with high risk for developing diabetes complications. Methods We performed a genome-wide association study in 601 type 2 diabetes patients after stratifying them according to the presence or absence of four types of diabetes complications: diabetic neuropathy, diabetic nephropathy, macrovascular complications, and ophthalmic complications. Results The analysis revealed ten novel associations showing genome-wide significance, including rs1132787 ( GYPA, OR = 2.71; 95% CI = 2.02–3.64) and diabetic neuropathy, rs2477088 ( PDE4DIP , OR = 2.50; 95% CI = 1.87–3.34), rs4852954 ( NAT8 , OR = 2.27; 95% CI = 2.71–3.01), rs6032 ( F5 , OR = 2.12; 95% CI = 1.63–2.77), rs6935464 ( RPS6KA2 , OR = 2.25; 95% CI = 6.69–3.01) and macrovascular complications, rs3095447 ( CCDC146 , OR = 2.18; 95% CI = 1.66–2.87) and ophthalmic complications. By applying the targeted approach of previously reported susceptibility loci we managed to replicate three associations: MAPK14 (rs3761980, rs80028505) and diabetic neuropathy, APOL1 (rs136161) and diabetic nephropathy. Conclusions Together these results provide further evidence for the implication of genetic factors in the development of type 2 diabetes complications and highlight several potential key loci, able to modify the risk of developing these conditions. Moreover, the candidate variant approach proves a strong and consistent effect for multiple variants across different populations.
    Type of Medium: Online Resource
    ISSN: 1755-8794
    URL: Article
    DOI: 10.1186/s12920-020-00860-4
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2411865-5
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