In:
The American Journal of Chinese Medicine, World Scientific Pub Co Pte Ltd, Vol. 44, No. 02 ( 2016-01), p. 275-290
Abstract:
Litsea verticillata Hance (Lauraceae), a Chinese medicine used to treat swelling caused by injury or by snake bites, was the first plant identified by our National Institutes of Health (NIH)-funded International Cooperative Biodiversity Group (ICBG) project to exhibit anti-HIV activities. From this plant, we discovered a class of 8 novel litseane compounds, prototypic sesquiterpenes, all of which demonstrated anti-HIV activities. In subsequent studies, 26 additional compounds of different structural types were identified. During our continuing investigation of this plant species, we identified two new litseanes, litseaverticillols L and M, and a new sesquiterpene butenolide, litseasesquibutenolide. Litseaverticillols L and M were found to inhibit HIV-1 replication, with an IC[Formula: see text] value of 49.6[Formula: see text] [Formula: see text]M. To further determine the antiviral properties of this plant, several relatively abundant isolates, including a litseane compound, two eudesmane sesquiterpenes and three lignans, were evaluated against an additional 21 viral targets. Lignans 8 and 9 were shown to be active against the Epstein–Barr Virus (EBV), with EC[Formula: see text] values of 22.0[Formula: see text][Formula: see text] M ([Formula: see text]) and 16.2[Formula: see text] [Formula: see text]M ([Formula: see text] ), respectively. Since many antiviral compounds have been discovered in L. verticillata, we further prepared 38 plant extracts made from the different plant parts of 9 additional Litsea species. These extracts were evaluated for their anti-HIV and cytotoxic activities, and four of the extracts, which ranged across three different species, displayed 97–100% inhibitory effects against HIV replication without showing cytotoxicity to a panel of human cell lines at a concentration of 20[Formula: see text][Formula: see text] g/mL.
Type of Medium:
Online Resource
ISSN:
0192-415X
,
1793-6853
DOI:
10.1142/S0192415X16500166
Language:
English
Publisher:
World Scientific Pub Co Pte Ltd
Publication Date:
2016
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