In:
Molecular Systems Biology, EMBO, Vol. 9, No. 1 ( 2013-01)
Abstract:
Quantitative proteomics, lifespan analysis, and biochemical assays were utilized to show that Insulin/IGF‐1‐mediated longevity in C. elegans is strongly associated with a daf‐16 dependent global reduction in protein metabolism. image A daf‐16 dependent global reduction in protein translation is observed in daf‐2 long‐lived mutant. The reduction in active translation is independent of germline activity A role for protein metabolism is identified in the Insulin/IGF‐1‐mediated extension of life.
Type of Medium:
Online Resource
ISSN:
1744-4292
,
1744-4292
Language:
English
Publisher:
EMBO
Publication Date:
2013
detail.hit.zdb_id:
2193510-5
SSG:
12
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